432results about How to "Good solubilization effect" patented technology

The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.

The invention relates to a plugging removal and stimulation method for a low permeability oil well. The ultra-low resistance acid-type microemulsion is prepared by the following components: 10%-25% of acid, 5%-20% of oil, 5%-25% of alcohol, 0.5%-5% of surfactant, 0.5%-3% of inorganic salt, 0.3-1.5% of corrosion inhibitor and the balance water. The method comprises the following steps: injecting the prepared microemulsion in the oil bearing reservoir of the oil well, closing the oil well to react for 4-10h, cleaning the oil well, flowing the reaction exhaust liquor back, and completing the oilwell to perform normal production. The ultra-low resistance acid-type microemulsion used by the invention has thermodynamic stability, is a high dispersive acid-type microemulsion with good solubilization capacity, has ultra-low surface and interfacial tensions and good solubilization capacity and can increase the dispersive capacity of crude in water and the emulsification and peeling function to oil film; the microemulsion also has good dissolubility in water or oil and good fluidity due to high carrying capability and low seepage resistances so that the oil yield of the oil well is increased and the water content is reduced; the liquid surface tension in oil reservoir is reduced and the flow resistance of the crude is lowered so that the mining rate of the crude is increased and the plugging removal and stimulation of the oil well can be realized.

The present invention relates generally to chemical and biological decontamination solutions and methods of using them. The invention is useful for decontaminating a wide range of compounds and organisms. In particular, the systems, methods, solutions, and formulations of the invention can be used to remove and / or neutralize organophosphates and other toxic chemicals, bacteria, bacterial spores, fungi, molds and viruses.

The invention discloses an antiallergic microemulsion, which contains: sorbitan sesquioleate and PEG‑60 sorbitan stearate; one or more oily components, Selected from hydrocarbon oils, synthetic oils, animal and vegetable oils, silicone oils and mixtures thereof; polyhydric alcohols and water; one or more water-soluble antiallergic raw materials. The microemulsion is a water-in-oil system, has good stability, can be stored for a long time, has a good solubilizing effect on water-soluble anti-allergic raw materials, and can be made into products with higher functional components.

The invention relates to a novel passive targeting nano emulsion with skin whitening effect and a preparation method thereof. The invention uses a novel passive targeting transdermal delivery dosing system TDDS-nano emulsion as a carrier of a function component for whitening or lighting the skin, uses different physical and chemical properties, action mechanism and actual effect of each skin whitening function component, especially the action advantages of certain novel skin whitening function components, and provides skin whitening effect nano emulsion systems with two joint applications in morning and evening matched with each other. The two joint applied nano emulsion systems not only have minimum spherical grains, extremely even distribution of nano-scale grains, remarkable passive targeting function, good transdermal absorption and strong penetrability, but also have extremely even, exquisite, smooth and glossy texture of the nano emulsion, is quite comfortable after coating on the face or the skin, has no stimulus and good stability; and the nano is light yellow, beautiful in appearance, bright and transparent, clear and crystalline, has light opalescence, and is adhesive but not sticky, thick but not heavy, oily but not greasy.

The invention relates to a method for preparing a gydroxysulfobetaine amphoteric surface active agent including a polyether chain segment, belonging to the technical field of preparation of surface active agents. The gydroxysulfobetaine amphoteric surface active agent including the polyether chain segment is prepared by taking fatty amine polyoxyethylene ether and 3-chlorine-2-hydroxyl propane sodium sulfonate as raw materials. The gydroxysulfobetaine amphoteric surface active agent including the polyether chain segment is shown as a chemical structural formula in the specification. According to the gydroxysulfobetaine amphoteric surface active agent including the polyether chain segment synthesized by using the method disclosed by the invention, three hydrophilic groups consisting of polyoxyethenyl, quaternary ammonium salt and sulfonyl and hydrophobic alkyl are included; the gydroxysulfobetaine amphoteric surface active agent including the polyether chain segment has the two good surface activities of the non-ionic and amphoteric surface active agent; in addition, besides the good performance of the traditional gydroxysulfobetaine amphoteric surface active agent, the performances, such as water solubility, detergency, emulsifiability, dispersibility, solubilising power and the like, are improved obviously.

The invention relates to preparation and application of an amphiphilic ursolic acid-polysaccharide coupled substance with antitumor activity. The ursolic acid is chemically modified to substitute C3 site carboxyl group with amino group, the generated aminated ursolic acid is chemically coupled to a polysaccharide framework to form the amphiphilic ursolic acid-polysaccharide coupled substance, and the amphiphilic ursolic acid-polysaccharide coupled substance can be self-assembled into a nano micelle in water. The method is characterized in that the antitumor activity of the chemically modified ursolic acid is obviously enhanced; the hydrophobic inner core formed by the hydrophobic group can physically wrap the antineoplastic drug to obviously improve the solubility of the antineoplastic drug; and the antineoplastic drug which is physically wrapped by the chemically coupled ursolic acid can implement combined chemotherapy, has higher antitumor activity, has the combined synergetic action, and lowers the toxicity. The preparation method is simple and easy to operate, has the advantage of higher yield, and can easily implement industrialization.

An injection which contains as the active ingredient a pyrazolone derivative which typically is Edaravone, a physiologically acceptable salt thereof, or a hydrate or solvate of either in an amount of 3 to 60 mg / mL. It is excellent in long-term stability, product storage, and suitability for use.

The invention provides a low-foam middle-cloud-point environment-friendly water base metal cleaner composition and a preparing method thereof, and belongs to the field of metal cleaners. The low-foam middle-cloud-point environment-friendly water base metal cleaner composition is composed of low-foam low-cloud-point nonionic surface active agents, low-foam anion surface active agents, triethanolamine oleic soap, triethanolamine, styrene acrylic three azole nitrogen, ethylene diamine tetraacetic acid, sodium carbonate, polyether, organosilicone, sodium hydroxide and deionized water, wherein solid-phase raw material and liquid-phase raw material are sequentially added to a reaction container according to a formulation and metering, the organosilicone and the deionized water are finally added to the reaction container, stirring is conducted for 10min to 20min under the condition of indoor temperature, and clear products with a pH value ranging from 9 to 10 are obtained. The triethanolamine oleic soap is a cloud point improving agent, good water solubility is achieved after the triethanolamine oleic soap and the triethanolamine are re-compounded according to the ratio, solubilizing ability of the low-foam low-cloud-point nonionic surface active agents is enhanced, therefore the temperature of the solution cloud point of the cleaner is improved to 45 DEG C, cleaning efficiency of the cleaner is improved, and the low-foam middle-cloud-point environment-friendly water base metal cleaner particularly suitable for high-pressure spraying cleaning is obtained.

Compositions in powder form of sterols or stanol esters, and milk powder and / or proteins are disclosed. A process of making the compositions is also disclosed. The suitability of incorporation of the compositions in powder form in food products, for example beverages and milk products, is also disclosed.

A freeze-dried powder injection of high-dosage (500mg) ambroxol hydrochloride and its preparing process are disclosed.

The invention discloses an abietyl-based soldering flux for a halogen-free no-clean bright solder wire and a preparation method thereof. The abietyl-based soldering flux comprises, by mass, raw materials including active agent 3.50-15.00%, surface active agent 0.08-0.42%, brightener 0.10-2.50%, corrosion inhibitor 0.10-0.45%, cosolvent 1.50-6.00% and the balance modified rosin. The ingredient proportion in the abietyl-based soldering flux is suitable for manufacture of lead-free solder wires containing the soldering flux in cores, and the soldering flux can be used for automatic welding or manual soldering iron welding. When the solder wire welding is adopted, the process stability is good, tinning speed is high, the splashing amount is small, the defects including continuous tinning, solder skips, insufficient solder, icicles and the like in the welding process can be decreased, welding spots are bright and full after welding, residues are few, the corrosivity is low, cleaning is not needed, and the surface electrical insulation property is excellent after the welded solder wires are placed for a long period of time.

The invention provides a tacrolimus sustained-release preparation and a preparation method thereof. The invention adopts a solid dispersion technology, or cyclodextrin inclusion technology or a solubilizing method for micronizing drugs and then adding one or more types of surfactants and the like, and obviously improves solubility thereof so as to improve the bioavailability thereof, then adds oneor more types of skeleton materials and other auxiliary materials so as to prepare a skeleton type sustained-release preparation, or adopts a sustained-release material to carry out coating so as toprepare a diaphragm-controlled type or osmotic pump type sustained-release preparation. The tacrolimus sustained-release preparation has better solubility and dissolution rate, high bioavailability and sustained-controlled-release effect, thus maintaining stable blood and drug concentration, reducing the occurrence rate of adverse reaction, and improving clinical drug safety; in addition, the invention has easy obtaining for materials, simple and feasible preparation technique, high yield and low cost, can realize large-scale industrialized production and has obviously economical benefit.

The invention relates to a neutral blocking remover composition for oilfield oil extraction, which is prepared from the following components in parts by weight: 30-35 parts of acrylic acid-methyl acrylate copolymer, 44-50 parts of diethylene triamine pentaacetic acid, 30-35 parts of sodium polyepoxysuccinate, 30-35 parts of amine malate, 10-14 parts of sodium alkyl sulfonate, 5-8 parts of amine hydroxy ethylidene diphosphate, 10-14 parts of hydrolyzed polyacrylamide, 12-17 parts of atlapulgite, 20-25 parts of sodium persulfate, 7-10 parts of sodium lignosulfonate, 5-8 parts of tannin, 12-16 parts of sodium malate, 5-8 parts of sodium sulfosuccinate, 5-8 parts of starch, 9-12 parts of methyl lactate, 0.2-0.3 part of vanadium pentoxide and 0.1-0.3 part of diisobutyl carbinol. The neutral blocking remover composition for oilfield oil extraction has the advantages of high blocking removal speed, no corrosivity due to neutrality and no dead area, can quickly dissolve the material scales, clean the oilfield stratum and remove blocking, and does not generate the phenomenon of precipitation or secondary blocking; and the cleaning waste liquid does not need to be subjected to sewage treatment after returning to the ground.

A non-toxic ionic liquid used as the solvent, cosolvent, or surfactant for increasing the water-solubility of the medicines difficult to dissolve in water features that its cation is alkylimidazole salt with short carbon chain or quaternary ammonium salt.

The invention discloses a microemulsion-type washing liquid system for an oil-based drilling fluid and a preparation method thereof. The microemulsion-type washing liquid system mainly solves the problem that the existing washing solution has low washing efficiency, a poor wetting reversion function and poor interface bonding quality. The washing liquid system comprises a microemulsion-type washing agent and a base liquid. The microemulsion-type washing agent comprises, by weight, 100 parts of clear water, 4-6 parts of an anionic surfactant, 3-6 parts of a nonionic surfactant, 6-10 parts of a cosurfactant and 7-15 parts of a salt. The base liquid is an aqueous solution containing a certain mass percentage concentration of a weighting agent and polymers. When the washing liquid contacts with an oil phase in the oil-based drilling fluid, a microemulsion can spontaneously form, can efficiently remove the residual oil-based drilling fluid, has a good wetting reversion capability, guarantees bonding of a cement sheath and an annulus interface and has a wide application prospect.

The present invention discloses one kind of freeze dried polyene phosphatidylcholine powder for injection and its preparation process. It features that the preparation contains polyene phosphatidylcholine and solubilizer sodium deoxycholate, sodium dehydrocholate or sodium cholate in the weight ratio of 0.5-1.5.

The invention discloses a wear-resistant and high-hardness ceramic product and a preparation method thereof. The wear-resistant and high-hardness ceramic product comprises a green body and a glaze layer applied on the green body. The green body comprises the following raw materials by weight: 45-55 parts of kaolin, 5-10 parts of zirconia, 12-18 parts of bentonite, 15-25 parts of waste ceramic residue, 10-15 parts of silicon nitride, 17-23 parts of potassium feldspar, and 8-16 parts of albite. The glaze layer consists of the following raw materials by weight: 25-35 parts of kaolin, 12-16 partsof talc powder, 10-15 parts of spodumene, 6-12 parts of lithium china stone, 10-15 parts of quartz, 5-10 parts of silicon carbide and 7-14 parts of calcite. By the above way, the ceramic product provided by the invention has high hardness and wear resistance, high compressive strength and strong thermal stability.

The invention relates to a ceramic membrane cleaning agent, which is characterized by comprising the following compositions in portion by mass: 50 to 60 mass portions of sodium hydroxide, 20 to 30 mass portions of calcium hydroxide, 5 to 10 mass portions of sodium hypochlorite, 5 to 10 mass portions of sodium dodecyl benzene sulfonate, 1 to 5 mass portions of sodium tetraborate, 1 to 10 mass portions of sodium silicate and 1 to 5 mass portions of methyl cellulose. The cleaning agent is simple and convenient to prepare, has good cleaning effect, has strong applicability on a Chinese medicinal liquid preparation, reduces the cleaning frequency of a membrane, does not need to disassemble a membrane tube, is easy and convenient to clean, is quick to restore the membrane flux, greatly shortens the cleaning time, reduces the energy consumption of a system, has small damage to the membrane tube, does not influence the service life of the membrane tube, avoids secondary pollution caused by the cleaning agent, and accelerates system regeneration.

The invention belongs to the field of pharmaceutical preparation and relates to an albumin nanometer particle preparation for soluble injection. The albumin nanometer particle, which is formed by combining albumin, indissolvable erlotinib drugs and adding phospholipid for scattering and stabilizing, is prepared into the albumin nanometer particle preparation for soluble injection. The enhancing permeation and detaining effect of nanometer particle to tumor are utilized by the albumin nanometer particle preparation provided by the invention, so that more drugs are passively targeted and gathered on a tumor tissue and the anti-tumor effect is increased. Meanwhile, the bioavailability of injection mode is high, the albumin nanometer particle preparation for soluble injection has a passive targeting function and the dosage is greatly reduced, so that the concentration of the drugs in non-target part is efficiently reduced, the reducing of the toxic side effect of the drugs is boosted and the clinical application prospect is excellent.

The invention discloses a compound acid blockage removing fluid. The blockage removing fluid is prepared from raw materials in parts by weight as follows: 4-6 parts of a foam flushing fluid, 20-30 parts of a prepad fluid, 70-100 parts of main acid and 10-20 parts of postpad fluid. The acid fluid has higher capacity of removing organic sediment pollution and high acid residue and emulsifying resistance. The acid fluid has low corrosion speed and good swelling inhibition and does not change the original water wetting characteristic of the stratum.

This invention discloses a drug solubilization carrier and its preparation method and use. The carrier is made by separately inducting hydrophilic carboxymethyl or hydroxyethyl and hydrophobilic alkyl or alkyonyl on the 6 location and 2 location of chitose framework to produce amphipathic chitose derivatives that can combine to nanomicelle naturally. The carrier has low critical gathering concentration, high load capacity, little toxicity, high encapsulating ratio and has stable nanomicelle; it can be used as carrier for indissoluble or micro-dissoluble drugs. For this invention has simple processing method and mature technics, it fits to large-scale series production.

The invention belongs to the field of medicinal preparation, and relates to taxane medicines albumin nanoparticle preparation for injection and a preparation method of the preparation. According to the invention, the albumin nanoparticle preparation is prepared by combining the albumin with the taxane medicines to form the albumin nanoparticles by dispersing and stabilizing with the phospholipid. According to the invention, the strengthened osmosis and retention effect on the tumors by the nanoparticles are utilized, and more medicines are passively targeted and concentrated on the tumor tissues so as to improve the antitumor effect; simultaneously, due to the fact that the bioavailability in the injection way is high and the soluble albumin nanoparticle preparation for injection exists passive targeting, the administration dose can be greatly reduced, so that the medicinal concentration on the non-target parts can be effectively reduced, the toxic and side effects of the medicines can be reduced, and the good clinical application prospect can be implemented. The preparation is convenient in preparation method and is suitable for industrial mass production.

The invention discloses an oil-in-water cinnamic aldehyde nano emulsion medicament. The particle diameter of the nano emulsion is between 10 and 100 nanometers; and the medicament is prepared from the following raw materials: 18.09 to 37.19 percent of surfactant, 0 to 6.86 percent of cosurfactant, 0 to 8.62 percent of oil, 0.10 to 8.31 percent of cinnamic aldehyde and the balance of distilled water, wherein the mass percentage sum of the components is 100 percent. According to the oil-in-water cinnamic aldehyde nano emulsion medicament, the dissolubility of the cinnamic aldehyde is enhanced, the stability of the medicament is improved, the bioavailability is improved, the medicament metabolizing time of the cinnamic aldehyde in vivo is delayed, the consumption of the auxiliary material is reduced, and the production cost is lowered; and the medicament has broad market prospect in the field of medicine.

The invention provides a cefdinir capsule and a preparation method of the cefdinir capsule. The content of the cefdinir capsule comprises the necessary components based on parts by weight: 70-90 parts of cefdinir, 0.01-5 parts of polyoxyl (40) ester stearate, 0.2-5 parts of silicon dioxide, 0.1-5 parts of magnesium stearate and 5-30 parts of hydroxypropyl cellulose. The medicine prepared by cefdinir capsule prescription is good in dissolution effect and fluidity, and stable in medicine effect; the provided preparation method is simple in technology; the product is less in introduced impurity, easy in quality control and good in reproducibility and uniformity; and the preparation method saves the energy and reduces the consumption, thus easily meeting the demand of mass production.

The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters uing a biphasic solvent system. More particularly, the present invention relates to the enzyme-mediated enantioselective synthesis of anti-viral compounds, such as 2-hydroxymethyl-5-(5-flurocytosin-1-yl)-1,3-oxathiolane (FTC) and its analogues, in a non-homogenous reaction system.

The invention discloses a reaction type VOCs absorbent. The reaction type VOCs absorbent comprises the following components by mass percent: 92% to 97% of water, 0.2% to 1% of a surfactant, 0.5% to 1% of inorganic salt and 0.2% to 1% of an organic matter decomposing agent, wherein the surfactant is at least one in castor oil sodium sulfonate, sodium sulpho methyl stearate, Tween 20, Tween 80, alkyl glycoside, sodium citrate and sodium dodecyl benzene sulfonate; inorganic salt is at least one in sodium carbonate, potassium carbonate, sodium metasilicate, sodium chloride, potassium chloride and ammonium chloride; and the organic matter decomposing agent is at least one in cysteine hydrochloride, arginine, lysine, histidine, 2-imidazolidone, acethydrazide and adipic dihydrazide. The reaction type VOCs absorbent has the advantages that multiple components in VOCs can be treated at the same time, the removing efficiency for volatile organic matters is high, the organic matter decomposing agent in the components of the absorbent can degrade organic exhaust gas into CO2 and water or other micromolecules, the raw materials are wide in source, the cost is low, and follow-up treatment is simple.