The invention discloses a preparation method of a supramolecular water plugging agent for improving a water-intake profile of an oil pool. The preparation method of the supramolecular water plugging agent for improving the water-intake profile of the oil pool comprises a mass fraction formula and a making method, wherein the mass fraction formula is that the ratio of modified phenolic resin to a polymer to a hydroxyl compound to a high-price metal salt to water is equal to (0.05 to 0.3): (0.005 to 0.08): (10 to 20): (0.2 to 0.8): (80 to 90); according to the formula, a supporting agent modified polyacrylamide is added into the water in a certain proportion, an obtained mixture is uniformly agitated, and then the hydroxyl compound is added into the agitated obtained mixture, and a newly obtained mixture is uniformly agitated. Afterwards, the modified phenolic resin is added into the newly obtained mixture, subsequently, a conditioning agent high-price metal salt is added into a finally obtained mixture, and an obtained product is mixed. The preparation method of the supramolecular water plugging agent for improving the water-intake profile of the oil pool has the advantages that a system having viscoelasticity and particle property at the same time can be formed; the supramolecular water plugging agent has favorable chemical stability and heat stability, and is resistant to a temperature up to 90 DEG C. The supramolecular water plugging agent has the characteristics of low viscosity, good pumpability, good injectivity, simple site operation, safety and reliability, and can dynamically penetrate into the deep part of the oil pool for carrying out plugging, so as to improve the water-intake profile of the oil pool, and to achieve the purpose of changing the direction of a liquid flow.