The invention provides a preparation method of high oil loaded nutrition lipid micro-capsule powder with tolerance to mechanical stirring. The preparation method comprises the following steps: adding protein type wall materials into water, stirring for dissolving the materials at 40-70 DEG C, adjusting the pH of an obtained solution to 7.0-12.0, reacting under the condition of 40-70 DEG C for 0.5-4 hours, adding sugar type wall materials and a stabilizing agent into an obtained reaction solution, and stirring for dissolving, thereby obtaining a water phase solution; adding an antioxidant and an emulsifier into nutrition lipid type core materials, and stirring for dissolving at 40-70 DEG C, thereby obtaining an oil phase solution; and mixing the water phase solution with the oil phase solution, emulsifying and homogenizing, and spray-drying, thereby obtaining the micro-capsule powder. The content of total fat in the micro-capsule powder reaches up to 60%-85%, and the content of surface oil in the micro-capsule powder is lower than 5%. The micro-capsule powder has tolerance to mechanical force, is good in self-emulsifying capability, can be dissolved to form uniform and stable fine emulsion without floating particles and sediments, can be applied to the field of food, and can be added to food such as bread, cookies, nutrition bars and milk products and also be taken as solid granules.