Non-toxic ionic liquid, preparation method and its application

Abstract

A non-toxic ionic liquid used as the solvent, cosolvent, or surfactant for increasing the water-solubility of the medicines difficult to dissolve in water features that its cation is alkylimidazole salt with short carbon chain or quaternary ammonium salt.

Description

technical field [0001] The invention belongs to the synthesis of new ionic liquid in the field of chemical materials and its manufacture and the application in the field of medicine as a new solvent, co-solvent or surfactant. Background technique [0002] Ionic Liquids (Ionic Liquids) refer to positive ions such as organic alkylimidazoles, quaternary ammonium salts, and alkylpyridines and different negative ions such as chloride ions, BF 4 - , PF 6 - , CF 3 CO 2 - , N(CN) - 2 Many of them are liquid at room temperature or even at low temperature, so they are also called room temperature ionic liquids. Ionic liquids have the characteristics of no vapor pressure, good thermal stability (up to 300-400°C), good electrical conductivity, and are suitable for organic compounds, inorganic compounds, metal organic compounds, gases (H 2 , CO, O 2 etc.) have a wide range of solubility, can be miscible or insoluble with organic solvents, water to form a two-phase or multi-phas...

AI Technical Summary

Problems solved by technology

The most common ionic liquids mentioned above, such as: 1-methyl-3-butylimidazolium hexafluorophosphate, will be hydrolyzed in water to produce volatile and toxic HF and POF 3 , (R.P.Swalowski, J.D.Holbery, and R.D.Rogers, Green Chem., 2003, 5, 361.); 1-methyl-3-butylimidazole tetrafluoroborate its acute toxicity LD 50 =1.4g / kg (female rat), LD 50 =1.37g / kg (male rat) (J.Pernak, et.al., Ind.Eng.Chem.Res.2001, 40, 2379.), therefore, these commonly used ionic liquids all have certain toxicity, Cannot be used in medicine or as a food additive

In addition, in the pharmaceutical industry, there are many drugs that are insoluble in water and are difficult to be absorbed and utilized by the human body. Therefore, solving the solubility of insoluble drugs in water and improving the bioavailability of drugs are still difficult and hot issues in the pharmaceutical industry

The method that is often taken now is to dissolve the drug in the oil phase, and then add a surfactant to make an emulsion or microemulsion to improve the bioavailability of the drug, but this method needs to add a large amount of oil phase, and at the same time, it also needs to add surfactant Some of these additives have side effects on the human body. At the same time, due to the limited types of surfactants and co-solvents, the preparation process is complicated and the cost is high, and it cannot solve the solubility of all insoluble drugs in water.

Up to now, there is no report about ionic liquid as a new solvent, co-solvent or surfactant in the prior art for the preparation of new drug dosage forms or as food additives

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