Non-toxic ionic liquid, preparation method and its application

An ionic liquid and anion technology, applied in pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of insoluble drug solubility, limited types of co-solvents, complicated preparation processes, etc., and achieve good thermal stability, The effect of low cost and simple preparation process

Inactive Publication Date: 2009-05-27
HEBEI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some of these additives have side effects on the human body
At the same time, due to the limited types of surfactants and co-solvents, the preparation process is complicated and the cost is high
And it cannot solve the solubility problem of all poorly soluble drugs in water

Method used

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  • Non-toxic ionic liquid, preparation method and its application
  • Non-toxic ionic liquid, preparation method and its application
  • Non-toxic ionic liquid, preparation method and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of acetic acid 1-methyl-3-ethylimidazolium ionic liquid

[0027] According to the second synthesis method of ionic liquid: to 14.6 g of 1-methyl-3-ethylimidazole chloride, add 100 ml of acetone and 8.2 g of sodium acetate solid. After stirring for 24 hours, sodium chloride was removed by filtration. After purification, the solvent was evaporated to dryness under high vacuum at 45°C to obtain 16.3 g of a colorless ionic liquid of 1-methyl-3-ethylimidazolium acetate.

Embodiment 2

[0029] The preparation method of acetic acid 1-methyl-3-butylimidazolium ionic liquid

[0030] According to the second synthesis method of ionic liquid: to 17.5g of 1-methyl-3-butylimidazole chloride, add 100ml of acetone and 8.2g of sodium acetate solid. After stirring for 24 hours, sodium chloride was removed by filtration. After purification, the solvent was evaporated to dryness under high vacuum at 45°C to obtain 19.0 g of a colorless ionic liquid of 1-methyl-3-ethylimidazolium acetate.

Embodiment 3

[0032] The preparation method of stearic acid 1-methyl-3-ethylimidazolium ionic liquid

[0033] According to the second synthesis method of ionic liquid: to 14.6g of 1-methyl-3-ethylimidazole chloride, add 100ml of acetone and 22..2g of sodium stearate solid. After stirring for 24 hours, sodium chloride was removed by filtration. After purification, the solvent was evaporated to dryness under high vacuum at 45°C to obtain 30.0 g of colorless waxy 1-methyl-3-ethylimidazolium stearic acid ionic liquid.

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Abstract

A non-toxic ionic liquid used as the solvent, cosolvent, or surfactant for increasing the water-solubility of the medicines difficult to dissolve in water features that its cation is alkylimidazole salt with short carbon chain or quaternary ammonium salt.

Description

technical field [0001] The invention belongs to the synthesis of new ionic liquid in the field of chemical materials and manufacturing and its application in medicine and pesticide as a new solvent, co-solvent or surfactant. Background technique [0002] Ionic Liquids (Ionic Liquids) refer to positive ions such as organic alkylimidazoles, quaternary ammonium salts, alkylpyridines and different negative ions such as chloride ions, BF 4 - , PF 6 - , CF 3 CO 2 - , N(CN) - 2 Many of them are liquid at room temperature or even at low temperature, so they are also called room temperature ionic liquids. They have no vapor pressure, good thermal stability (up to 300-400°C), good electrical conductivity; for organic compounds, inorganic compounds, metal organic compounds, gases such as: H 2 , CO, O 2 It has a wide range of solubility; it can also be miscible with organic solvents, water, or insoluble to form a two-phase or multi-phase reaction system; the most notable is it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/22
Inventor 刘庆彬张占辉张福军
Owner HEBEI NORMAL UNIV
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