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Cefdinir capsule and preparation method thereof

A technology of dini capsules and cefdinir, which is applied in the field of cefdinir capsules and its preparation, can solve problems such as difficult sieving, poor operability, and large loss, and achieve high production efficiency, good dissolution effect, and low cost. low effect

Active Publication Date: 2013-02-20
海南三叶美好制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And adopt 200 mesh sieves to sieve raw material medicine in its preparation process, easily appear the phenomenon that is difficult to sieve in production practice, and loss is very large, operability is not strong

Method used

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  • Cefdinir capsule and preparation method thereof
  • Cefdinir capsule and preparation method thereof
  • Cefdinir capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of cefdinir capsule, the essential ingredient in its content is made up of the composition of following parts by weight:

[0029]

[0030] Described cefdinir capsule, it adopts the preparation method that has the following steps to make:

[0031] 1) Grinding and sieving: mix polyoxyl (40) stearate and silicon dioxide according to the prescription ratio, grind and sieve, the mesh size of the sieve is 60 mesh; hydroxypropyl cellulose, magnesium stearate and Cefdinir crude drug is sieved respectively, and the sieve mesh number is 80 orders;

[0032] 2) Mixing: Weigh the raw materials prepared in step 1) according to the prescription amount, first mix the mixed powder of polyoxyl (40) stearate and silicon dioxide and magnesium stearate and mix well, then Mix with hydroxypropyl cellulose according to the method of equal increase, finally add the cefdinir raw material, mix in the mixer for 20 minutes, and get the content required for filling the capsule;

[0033] ...

Embodiment 2

[0037] A kind of cefdinir capsule, the essential ingredient in its content is made up of the composition of following parts by weight:

[0038]

[0039] Described cefdinir capsule, it adopts the preparation method that has the following steps to make:

[0040] 1) Grinding and sieving: mix polyoxyl (40) stearate and silicon dioxide according to the prescription ratio, grind and sieve, the mesh number of the sieve is 80 mesh; hydroxypropyl cellulose and magnesium stearate are respectively Pass through a 60-mesh sieve, and the cefdinir bulk drug pass through an 80-mesh sieve;

[0041]2) Mixing: Weigh the raw materials prepared in step 1) according to the prescription amount, first mix the mixed powder of polyoxyl (40) stearate and silicon dioxide and magnesium stearate and mix well, then Mix with hydroxypropyl cellulose according to the method of equal increase, finally add cefdinir crude drug, and mix in a mixer for 30 minutes to obtain the content required for filling the c...

Embodiment 3

[0045] A kind of cefdinir capsule, the medicinal ingredient in its content is made up of the composition of following parts by weight:

[0046]

[0047] Described cefdinir capsule, it adopts the preparation method that has the following steps to make:

[0048] 1) Grinding and sieving: mix polyoxyl (40) stearate and silicon dioxide according to the prescription ratio, grind and sieve, the mesh number of the sieve is 80 mesh; hydroxypropyl cellulose and magnesium stearate are respectively Pass through a 60-mesh sieve, and the cefdinir bulk drug pass through an 80-mesh sieve;

[0049] 2) Mixing: Weigh the raw materials prepared in step 1) according to the prescription amount, first mix the mixed powder of polyoxyl (40) stearate and silicon dioxide and magnesium stearate and mix well, then Mix with hydroxypropyl cellulose according to the method of equal increase, finally add cefdinir crude drug, and mix in a mixer for 40 minutes to obtain the content required for filling the ...

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Abstract

The invention provides a cefdinir capsule and a preparation method of the cefdinir capsule. The content of the cefdinir capsule comprises the necessary components based on parts by weight: 70-90 parts of cefdinir, 0.01-5 parts of polyoxyl (40) ester stearate, 0.2-5 parts of silicon dioxide, 0.1-5 parts of magnesium stearate and 5-30 parts of hydroxypropyl cellulose. The medicine prepared by cefdinir capsule prescription is good in dissolution effect and fluidity, and stable in medicine effect; the provided preparation method is simple in technology; the product is less in introduced impurity, easy in quality control and good in reproducibility and uniformity; and the preparation method saves the energy and reduces the consumption, thus easily meeting the demand of mass production.

Description

technical field [0001] The invention relates to a cephalosporin drug and a preparation method thereof, in particular to a cefdinir capsule and a preparation method thereof. Background technique [0002] Cefdinir (cefdinir) is the third-generation oral cephalosporin developed by Fujisawa Company in Japan. It not only maintains high stability to β-lactamase, but also improves the performance of third-generation cephalosporins such as cefixime. It only has a strong effect on Gram-negative bacteria, but has a poor effect on Gram-positive bacteria. Cefdinir has the characteristics of broad antibacterial spectrum, high curative effect, and low toxicity. [0003] Cefdinir crude drug is light yellow powder, poor water solubility, easy to generate static electricity, poor fluidity, and extremely unstable under wet, light and heat conditions, prone to increase of related substances, affecting drug efficacy and safety. At present, carboxymethylcellulose calcium is often used as a disi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/546A61K47/38A61P31/04
Inventor 葛楠全丹李庆明
Owner 海南三叶美好制药有限公司
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