148 results about "Cefdinir" patented technology

The invention relates to a preparation method of cefdinir, comprising the following steps: reacting 7-amino-3-vinyl-8-oxy-5-thia-1- nitric heterocyclic dicyclo[4.2.0]octyl-2-en-2-carboxylic acid with (Z)-2-(2-aminothiazole-4-yl)-2-acetoxy imino thioacetic acid (S-2-benzothiazole)ester in the presence of organic base at low temperature; extracting, adjusting p H value, preparing the intermediate of the cefdinir, removing the ester-group protective group of the intermediate of the cefdinir to obtain the cefdinir. The preparation method uses the low-temperature reaction technique, capable of increasing the reaction yield and reducing the impurities generated by the high temperature reaction. The hydrolysis and crystallization process is very easily controlled. The used alcohols, ketones or esters solvent is easily recovered, thus the production cost and the three-wastes drain are reduced, therefore the pollution to the environment is reduced. The preparation method of cefdinir is suitable for large-scale production.

The present invention relates to a process for the preparation of cefdinir on an industrial scale.

The invention relates to a Cefdinir capsule and a preparation method thereof. Each Cefdinir capsule contains equivalently 50-100mg of Cefdinir and also comprises a filling agent, a disintegrating agent, a solubilizer, a lubricating agent and a coating agent. The method of mixing and screening raw materials and hydrophilic excipients, granulating by adopting a material dry method and then coating with a moistureproof film coat is adopted in the invention, thus the drug in vitro release degree is improved, the activity of the Cefdinir is avoided from reducing in a high-moisture environment and the related substances of the Cefdinir are avoided from increasing, and the treatment effect, the stability and the safety of the drug are improved.

The present invention relates to cefdinir as one kind of cephalosporin, and is especially effervescent cefdinir preparation and its preparation process. The present invention features that the effervescent cefdinir preparation consists of cefdinir 15-25 wt%; disintegrating agent including acid 13-23 wt% and alkali 25-35 wt%; and other components including stuffing 14-24 wt%, adhesive 1-5 wt%, moistener 1-5 wt%, lubricant 5-9 wt%, sweetener 6-10 wt% and aromatic 8-16 wt%. The effervescent cefdinir preparation has the advantages of easy taking, fast absorption in body, good taste, etc.

High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt of cefdinir and reacting the crystalline salt with a base in a solvent.

The present invention relates to a stable and bioavailable crystalline form of a third generation cephalosporin antibiotic, cefdinir and a process for the preparation thereof. The present invention also relates to a pharmaceutical composition containing the novel crystalline cefdinir, useful in the treatment of maladies such as bacterial infections.

The present invention relates to a novel process for the preparation of a cefdinirby reacting O-acetyl thioester of Formula Iwithin the presence of a base in suitable solvent wherein R′ represents H or any carboxyl protecting group, and then converting to the cefdinir by the removal of protecting groups. This invention also relates to making the cefdinir using a novel process to prepare the O-acetyl thioester intermediate (Formula I) by condensing (Z)-2-(2-amino-4-thiazolyl)-2-acetyloxyiminoacetic acid with bis(benzothiazol-2-yl)disulphide in the presence of triphenylphosphine and a base in a suitable solvent.

The invention relates to a cefdinir compound and a preparation method thereof. In the method, the crude product of cefdinir prepared by the prior art is processed by the following steps to obtain a relatively pure cefdinir compound: aqueous alkali is added into the crude product of the cefdinir and full reaction is conducted till a clear solution is obtained, and then a cefdinir solution is obtained, and the cefdinir solution is absorbed with added active carbon and filtered; or the crude product of cefdinir is dissolved in an organic solvent and reacts with the added aqueous alkali to obtain a cefdinir solution, and the cefdinir solution is absorbed with added active carbon and filtered; and then the two filter liquors are added with acid or solid acid salt respectively; and crystal is separated out, filtered, washed and dried to obtain a cefdinir refined product.

The present invention relates to a process for the preparation of cedinir on an industrial scale.

The invention relates to a preparation method of a medicinal preparation taking cefdinir as a main ingredient, and in particular relates to the preparation method of a cefdinir dispersible tablet. The method comprises the following steps: taking the cefdinir in a therapeutic dose as a main raw material; micronizing the cefdinir to form the powder with the particle diameter of 60 to 150 mu m; adding assistant medicinal materials in proper quantity into the cefdinir to be directly pelletized by using a dry method; and directly pressing a pellet into the tablet, wherein the assistant medicinal materials comprise micronized milk sugar or starch, microcrystalline cellulose, aspartame and cross-linking povidone. The cefdinir dispersible tablet comprises the following ingredients in parts by weight: 100 parts of the cefdinir, 30 to 100 parts of the starch, 80 to 200 parts of the microcrystalline cellulose, 5 to 15 parts of the aspartame, 8 to 20 parts of the cross-linking povidone and 20 to 50 parts of magnesium stearate. The method provided by the invention has the advantages that the operation is simple; and the prepared cefdinir dispersible tablet is stable in quality, rapid in dissolution rate and high in bioavailability.

Cefdinir crystalline salts of formula (I),in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir are herein disclosed. The salts of formula (I) can be obtained from cefdinir intermediates or crude cefdinir by treatment with phosphoric acid.