47 results about "Cefpodoxime Proxetil" patented technology

A pharmaceutical composition comprising a solid unit dosage form comprising: one or more of pharmaceutically active ingredients selected from valacyclovir, olanzapine, voriconazole, topotecan, artesunate, amodiaquine, guggulosterone, ramipril, telmisartan, tibolone, atorvastatin, simvastatin, amlodipine, ezetimibe, fenofibrate, tacrolimus, valgancyclovir, valsartan, clopidrogel, estradiol, trenbolone, efavirenz, metformin, pseudoephedrine, verapamil, felodipine, valproic acid / sodium valproate, mesalamine, hydrochlorothiazide, levosulpiride, nelfinavir, cefixime and cefpodoxime proxetil in combination with a water insoluble polymer and / or a water soluble polymer. Methods for making the pharmaceutical composition are also disclosed.

A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics wherein X is chlorine or bromine; R is hydrogen, C1-4 alkyl group, an easily removable hydroxyl protective group, —CH2COOR5, or —C(CH3)2COOR5, wherein R5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV1), wherein X, R and R5 are as defined above, with N,N-dimethylformiminium chloride chlorosulphate of formula (VII) in an organic solvent at a temperature ranging from −30° C. to −15° C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.

The invention specifically discloses a cefpodoxime proxetil taste-masking granule and a preparation method thereof, belonging to the field of medicinal preparations. The taste-masking granule is prepared through mixing of a coated cefpodoxime proxetil pellet and a taste-masking particle, wherein the coated cefpodoxime proxetil pellet is of a structure composed of three layers, i.e., a drug-loadedpellet, a separating layer and a smoothing layer from interior to exterior. The main objective of the invention is to overcome the problems that current commercially-available cefpodoxime proxetil products immediately produce unpleasant bitter taste when child patients take the products; the taste of the cefpodoxime proxetil products is bad, which leads to poor medication compliance of child patients; and the cefpodoxime proxetil products have to be dissolved in water before taking, which leads to inconvenience in administration. To improve the medication compliance of children, the inherent bitter taste of cefpodoxime proxetil is totally masked, and components like a sweetener applicable to children are increased, so the bitter taste of the chemical drug is eliminated and fragrant smell is increased; and thus, child patients easily accept the granule and are pleasant to the fragrant smell, so the medication compliance of children is improved. Besides improvement of the medication compliance of children, the granule provided by the invention also overcomes the problem of inconvenience in administration of children by adding special adjuvants which allow children to take the granulethrough direct swallowing without dissolving in water into a prescription.

The present invention discloses one kind of soft cefpodoxime proxetil capsule and its preparation process. The medicine consists of medicine liquid and capsule shell, the medicine liquid contains cefpodoxime proxetil, matrix and stabilizer, and the capsule shell contains gelatin, glycerin, water, preservative and light screening agent. Compared with available cefpodoxime proxetil preparations, the present invention is even suitable for children and other people incapable of taking care of himself to take and has the advantages of high bioavailability, high stability, accurate content, etc.

Highly pure cefpodoxime proxetil can be prepared by a simple process comprising the step of reacting a cefpodoxime salt with 1-iodoethylisopropylcarbonate in an organic solvent in the presence of a crown ether.

The invention relates to a cefpodoxime proxetil compound and a preparation method thereof. In the method, the crude product of cefpodoxime proxetil prepared by the prior art is processed by the following steps to obtain a relatively pure cefpodoxime proxetil compound: the crude product of cefpodoxime proxetil dissolves in an organic solvent A; alkali or an organic alkalescent saline solution is added and the mixture is stirred for reaction and hydrolyzed to obtain cefpodoxime salt; the cefpodoxime salt is absorbed with added active carbon and filtered; and then 1-iodoethyl isopropyl carbonic ester is added and reaction is conducted in the presence of an organic solvent B to obtain cefpodoxime proxetil.