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Cefpodoxime proxetil tablet and production process thereof

A technology of cefpodoxime axetil and tablets, applied in the field of cefpodoxime axetil tablets and its production process, can solve the problems of unfavorable industrial production, low yield of tablets, complicated preparation process, etc., achieve low cost, reduce preparation steps, process simple effect

Inactive Publication Date: 2018-11-16
邓倩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And most of the used auxiliary materials of the method for preparing cefpodoxime axetil tablet now, and preparation process is complicated, and the tablet yield of used equipment preparation is lower, is unfavorable for suitability for industrialized production

Method used

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  • Cefpodoxime proxetil tablet and production process thereof
  • Cefpodoxime proxetil tablet and production process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A cefpodoxime axetil tablet, comprising the following raw materials in parts by weight: 30 parts of cefpodoxime axetil crude product, 10 parts of organic solvent A, 5 parts of organic weak alkaline salt solution, 10 parts of gac, 1-iodoethyl isopropyl 5 parts of carbonate, 6 parts of organic solvent B, 2 parts of filler, 2 parts of disintegrant, 6 parts of binder aqueous solution, 3 parts of EPO, 1 part of flavoring agent, 2 parts of sodium alginate, 1 part of isomalt.

[0021] The organic solvent A is a mixture of methanol, chloroform and tetrahydrofuran in a weight ratio of 1:2:4, and the organic solvent B is N,N-dimethylacetamide.

[0022] The filler is microcrystalline cellulose, the disintegrant is sodium carboxymethyl starch, and the flavoring agent is artificial chicken essence.

[0023] A kind of production technology of described cefpodoxime axetil tablet, comprises the following steps:

[0024] The preparation of S1 cefpodoxime axetil: dissolve cefpodoxime ...

Embodiment 2

[0031] A cefpodoxime axetil tablet comprises the following raw materials in parts by weight: 35 parts of cefpodoxime axetil crude product, 12 parts of organic solvent A, 8 parts of organic weak alkaline salt solution, 13 parts of gac, 1-iodoethyl isopropyl 7 parts of carbonate, 8 parts of organic solvent B, 4 parts of filler, 3 parts of disintegrant, 8 parts of binder aqueous solution, 4 parts of EPO, 2 parts of flavoring agent, 3 parts of sodium alginate, 2 parts of isomalt.

[0032] The organic solvent A is a mixture of methanol, chloroform and tetrahydrofuran in a weight ratio of 1:1:4, and the organic solvent B is N,N-dimethylacetamide.

[0033] The filler is anhydrous lactose, the disintegrant is sodium carboxymethyl starch, and the flavoring agent is artificial beef essence.

[0034] A kind of production technology of described cefpodoxime axetil tablet, comprises the following steps:

[0035] The preparation of S1 cefpodoxime axetil: dissolve cefpodoxime axetil crude...

Embodiment 3

[0042] A cefpodoxime axetil tablet comprises the following raw materials in parts by weight: 40 parts of cefpodoxime axetil crude product, 15 parts of organic solvent A, 10 parts of organic weak alkaline salt solution, 15 parts of gac, 1-iodoethyl isopropyl 8 parts of carbonate, 9 parts of organic solvent B, 5 parts of filler, 4 parts of disintegrant, 9 parts of binder aqueous solution, 5 parts of EPO, 4 parts of flavoring agent, 5 parts of sodium alginate, 3 parts of isomalt.

[0043] The organic solvent A is a mixture of methanol, chloroform and tetrahydrofuran in a weight ratio of 1:1:4, and the organic solvent B is N,N-dimethylacetamide.

[0044] The filler is maltodextrin, the disintegrant is sodium carboxymethyl starch, and the corrective agent is yeast powder.

[0045] A kind of production technology of described cefpodoxime axetil tablet, comprises the following steps:

[0046] The preparation of S1 cefpodoxime axetil: dissolve cefpodoxime axetil crude product in or...

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Abstract

The invention discloses a cefpodoxime proxetil tablet. The cefpodoxime proxetil tablet comprises the following raw materials by weight: 30 to 50 parts of crude cefpodoxime proxetil, 10 to 20 parts ofan organic solvent A, 5 to 15 parts of an organic weakly-alkaline salt solution, 10 to 20 parts of active carbon, 5 to 10 parts of 1-iodoethyl isopropyl carbonate, 6 to 12 parts of an organic solventB, 2 to 8 parts of a filling agent, 2 to 6 parts of a disintegrating agent, 6 to 12 parts of an aqueous binder solution, 3 to 7 parts of Eudragit with a registered trademark of EPO, 1 to 7 parts of acorrigent, 2 to 9 parts of sodium alginate and 1 to 5 parts of isomaltitol. The cefpodoxime proxetil tablet provided by the invention is directly prepared by using the crude cefpodoxime proxetil, so the waste of the cefpodoxime proxetil tablet caused by crude cefpodoxime proxetil is avoided, and a plurality of unnecessary preparation steps can be reduced at the same time; meanwhile, the quality ofa clinical preparation is improved for better solidification of pills of master drug components, so medication safety is guaranteed; and the method provided by the invention has the advantages of simple process, convenient operation, low cost and applicability to large-scale production.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a cefpodoxime axetil tablet and a production process thereof. Background technique [0002] Cefpodoxime axetil is widely used in human medicine for respiratory tract, urinary tract, obstetrics and gynecological infectious diseases and suppurative otitis media due to its broad-spectrum and powerful antibacterial effect and long half-life. Tablets, capsules, granules, dry suspensions. Cefpodoxime axetil is the third-generation oral broad-spectrum cephalosporin, which is hydrolyzed into cefpodoxime on the intestinal wall after oral administration and absorbed by the intestinal tract. Cefpodoxime has a broad-spectrum and powerful antibacterial effect and a long half-life, and is widely used in the treatment of respiratory tract, urinary tract, obstetrics and gynecology infectious diseases and suppurative otitis media. And most of the methods used for preparing c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K47/38A61K31/546A61P31/04
CPCA61K9/2866A61K31/546A61P31/04
Inventor 邓倩王迪张朝军耿左军
Owner 邓倩
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