The invention discloses a one-pot method for preparing
ceftazidime. The one-pot method includes the steps that 7-aminocephalosporanic acid,
ceftazidime side chain acyl chloride hydrochloride and
pyridine are weighed, placed in an ultrasonic wave reactor and ultrasonically oscillated for 2-3 h at the temperature of minus 18 DEG C-minus 15 DEG C and the power of 750-1000 W, the pH value is adjusted to 4.1-4.2,
acetone is added into a reaction solution, and a white
solid is separated, washed with cold water at the temperature of 0 DEG C-5 DEG C and dried to obtain
ceftazidime. In the method,
pyridine serves as an acid-binding agent and a catalyst for an
acyl chloride and
amidogen reaction, a reactant and reaction
solvent, other reagents are not added any more, and the
workload of
impurity research in the later period of new
drug research is greatly reduced. By means of environment-friendly
ultrasonic oscillation, after the reaction is completed, the
processing process is simple, the long
crystal growing process is avoided, and meanwhile the possible influence on product quality by
acetone residual amount due to
acetone washing after cold
water washing is avoided. The yield and the purity are high, and the method is suitable for industrial production.