32results about How to "Improve color grade" patented technology

The invention discloses a processing method of preserved kiwi fruits. The method comprises the following concrete steps: collecting fresh kiwi fruits, which are mature but hard, free of disease and insect damage, complete and high in sugar, as a raw material, washing the raw material, peeling the raw material, and vertically cutting each fruit in half; performing color-protecting and sugaring on pulps of the kiwi fruits; and finally, performing processes of drying, cooling and the like on the pulps of the kiwi fruits to prepare the finished preserved kiwi fruits. According to the method, the pulps of the kiwi fruits are subjected to color protecting by a sodium pyrosulfite solution, and the sugaring and drying processes of the pulps of the kiwi fruits are segmentally carried out, so that the preserved kiwi fruits can have the color of the original fruits and rich aroma and flavor of the kiwi fruits, have better competitive advantages than like products and have very remarkable market advantages.

The invention relates to a feed for regulating and controlling duck egg quality and intestinal health of Gaoyou ducks, relating to the technical field of nutrition and regulation and control of laying ducks. The feed is prepared from colza oil, corn flour, soybean meal, salt, DL-methionine, L-lysine hydrochloride, calcium hydrophosphate, fish meal and wheat bran. The feed is characterized by further comprising fructooligosaccharide, mannan oligosaccharide, flavones, citric acid and a premix. According to the feed provided by the invention, the deposition of natural pigments in the feed in the duck eggs can be promoted, the laying rate of the laying ducks can be also increased, the feed-gain ratio is lowered, and the duck egg quality is greatly improved in comparison with that of a control group. In addition, feeding the laying ducks by using the feed is beneficial to improvement of intestinal tract development form of duodenums of the laying ducks and reduction of the quantity of harmful bacteria in ceca.

The invention discloses a cefuroxime sodium new crystal type compound and a crystallizing preparation method thereof. The cefuroxime sodium new crystal type compound is prepared through a particle process crystal product molecular assembly and form optimizing technology. A stability test proves that the new crystal type compound has the advantages of being high in purity, low in impurity content, low in hygroscopicity and good in stability. Meanwhile, the invention discloses a preparation, cefuroxime sodium for injection. The preparation is prepared from cefuroxime sodium.

The invention provides a cefotaxime sodium preparation method. The method is characterized in that after an active group of 7-aminocephalosporanic acid is protected by a silanization reagent, subjecting to condensation reaction with AE-active ester to generate cefotaxime acid containing a protecting group; after deprotection of the cefotaxime acid containing the protecting group under the action of a deprotection agent, sequentially subjecting to aqueous-phase acidification and crystallization to obtain cefotaxime acid; subjecting the cefotaxime acid to salification and solvent crystallizationto obtain a pure product of cefotaxime sodium. In a whole technical process, a product degradation process is reduced, product quality is evidently improved, product market competitiveness is improved, and medication safety is further guaranteed.

The invention discloses a ceftazidime compound and a preparation thereof, namely ceftazidime for injection. The ceftazidime compound is prepared by adopting a coupling crystallization technology. The 'high-end medicine product refining crystallization technology development and industrialization project' won the second award for national scientific and technological progress in 2015, and the coupling crystallization technology belongs to one of the high-end medicine product refining crystallization technologies. The ceftazidime compound has the advantages of being high in purity, good in color grade and good in stability.

The invention discloses preserved artocarpus heterophyllus lam fruits and a processing method thereof. The method comprises the following concrete steps: with fresh artocarpus heterophyllus lam fruits as a raw material, cleaning the raw material, cutting, getting pulps, removing seeds to obtain pulp bracts, performing enzymolysis, color-protecting and sugaring on the pulp bracts, and finally, performing processes of drying, cooling and the like to prepare the finished product. According to the method, the sugaring and drying processes are segmentally carried out, so that the preserved artocarpus heterophyllus lam fruits are golden yellow in color and soft in mouth feel, and have the thick aromas of artocarpus heterophyllus lam; compared with fried artocarpus heterophyllus lam crisp chips, the preserved artocarpus heterophyllus lam fruits are healthier and have better competitive advantages than like products.

The invention discloses preserved cherry tomato fruits and a processing method thereof. The method comprises the following concrete steps: cleaning fresh cherry tomato fruits as a raw material, processing a plurality of holes in the cherry tomatoes fruits by a perforating machine, soaking the cherry tomato fruits in a sodium pyrosulfite solution for color-protecting, sugaring, and finally, performing processes of drying, cooling and the like to prepare the finished preserved cherry tomato fruits. According to the method, an effect of passivating phenolase is achieved while the color is protected, and the browning degree of the preserved cherry tomato fruits is lowered; the sugaring and drying processes are segmentally carried out, so that the preserved cherry tomato fruits can have the color and the flavor of original fruits and also retain the shapes of the original fruits, thus having better competitive advantages than like products.

The invention discloses a method for synthesizing cefoxitin acid. 7-aminocephalosporanic acid is adopted as a raw material and reacts with sodium methylate under protection of a protection agent, methoxy is introduced into the seventh bit of 7-aminocephalosporanic acid, and methoxide complex is obtained; after the reaction is finished, 2-thiophene acetyl chemical reagent is dropwise added for reacting, then solidifying enzyme is added to obtained wet feed in an alkaline solution for hydrolysis, and after hydrolysis is completed, solidifying enzyme is filtered out; after the reaction is finished, a benzathine diacetate water solution is dropwise added to reaction liquid, crystals are separated out, and a compound I is obtained; the compound I and an ammonia methoxyl acylation reagent act, a carbamyl methoxyl group is introduced to the third bit of the compound I, and cefoxitin acid is obtained. The synthesis process is simple, the steps are easy and convenient, implementation is easy, the yield is effectively increased, production cost is reduced, the production steps are reduced, the obtained product is high in purity, the impurity content is low, the color gradation is good, product quality is effectively improved, drug use safety is improved, and the method is suitable for mass production.

The invention relates to a synthesizing, purifying and identifying method of citric acid diethyl ester, which adopts the technical scheme that: in a reactor with a mixer, a thermometer, an extractor and a condenser, the molar ratio of the citric acid and the ethanol is 1: 1 to 30, entrainer and dehydration agent are added into the reactor, the products are evaporated at the temperature of 30 to 150 DEG C and cooled after being reacted for 2 to 10 hours, petroleum ether and distilled water are sequentially extracted for a plurality of times, the water layer is extracted, the products are distilled for 10 minutes after the pressure is released, and the products are thermally filtered to obtain the citric acid diethyl ester. Citric acid, citric acid diethyl ester and triethyl citrate are respectively potted on a silicon rubber G bed board and are unfolded inside a saturate tank, the unfolding agent is: butanol: glacial acetic acid: water= 4: 1: 5, iodine and bromcresol green alcohol are respectively used for color development, and the result of the color development by the iodine and the bromcresol gren alcohol is consistent with each other, the RT value of the citric acid is 3, and the RT value of the citric acid diethyl ester and triethyl citrate is 3.6. The citric acid diethyl ester which is synthesized by the above method has the advantages of high yield, high purity, good color, low cost and the like.

The invention discloses a new crystal form cefmenoxine hydrochloride compound and a crystallization preparation method thereof. The new crystal form cefmenoxine hydrochloride compound is prepared by adopting the particle process crystal product molecular assembling and morphology optimizing technology. The compound has the advantages of being high in purity and good in fluidity and stability. The invention also discloses a preparation which is prepared from the cefmenoxine hydrochloride compound, namely cefmenoxine hydrochloride for injection.

The invention discloses a method for preparing a carbon source used for synthesis of IIa type diamonds and belongs to a processing method for diamond synthesis raw materials. The method comprises the following steps: A, mixing high purity graphite with the graphite content of 99.9% or higher and diamond micro-powder together according to a ratio of (1999-1999.9):(0.1-1), and performing compression molding by using a press; B, continuously sintering the mixture obtained in the previous step for three times, wherein the primary sintering temperature is 1050-1150 DEG C, the secondary sintering temperature is 850-950 DEG C, and the tertiary sintering temperature is 750-850 DEG C. The high purity graphite with the graphite content of 99.9% or higher is mixed with the diamond micro-powder, and the mixture is subjected to three-time sintering and purification, so that the consistency and reliability of the finished carbon source are obviously improved. Moreover, the nitrogen content of the carbon source is effectively reduced, the color grade of the product is effectively improved, carburization is uniform during synthesis of IIa type diamonds, and the diamond growth surface is even.

The invention discloses a karat-grade diamond synthesizing device and a synthesizing method thereof. Firstly, a heating tube, a cellular module, a thermal-insulation pressure transfer piece, a heatingpiece and a metal sheet are utilized for being assembled into a synthesizing column, and then the synthesizing column is put into a pyrophyllite cavity body which is formed by buckling an upper halfpart pyrophyllite cup body and a lower half part pyrophyllite cup body to obtain a synthesized block; then the synthesized block is put into hexahedron synthetic diamond press to be synthesized to obtain karat-grade diamond. The synthesizing device utilized in a preparation method can provide completely independent growth environment for each particle of diamond, so that the diamond is ensured tostably, efficiently and excellently grow for a long time; by means of pyrophyllite inner through holes and a conducting column, heating power is reduced, electric energy is saved, energy is saved, emission is reduced, temperature homogeneity in the synthesizing cavity body is improved, and excellent diamond synthesis is improved. In a preparation process of the method, a synthesizing column is invacuum package, so that the synthesizing column is prevented from being oxidized in a synthesizing process, and impurity nitrogen is prevented from being increased.

The invention relates to a crystallization method of cefcapene ester hydrochloride monohydrate, which belongs to the field of medicine. The method comprises the following steps: adding solvents into cefcapene ester hydrochloride for dissolution; adding active carbon for decolourization; carrying out filtration and washing; adding hydrochloric acid water solution into obtained filter liquid for carrying out crystallization; filtering crystals; respectively washing the crystals by water and ethyl acetate; and carrying out drying to obtain the cefcapene ester hydrochloride monohydrate. The method of the invention can use a single solvent of methanol for crystallization to improve the recovery yield and reduce the production cost, and can also use mixed solvents of the methanol and ketone for crystallization to improve the quality of finished product. Low-temperature active carbon is used for decolourization, and the impurity control in the operation process can be ensured at the same time of ensuring the product quality (the control on the color grade, the endotoxin and the like). The baking temperature is reduced, the baking time is shortened, and the quality such as the color grade, the impurity content and the like of the products can be reached. The invention has the advantages of simplicity, easy implementation, low cost, good crystallization clarity, good color grade and easy control on the impurities of the finished products, is suitable for large-scale popularized application, and has obvious economic benefits.

The invention relates to a carboxylic acid penicillin dibenzyl (substituting benzyl) ethylenediamine salt compound and an application thereof in preparing a high-purification sodium oxacillin salt. The carboxylic acid penicillin dibenzyl (substituting benzyl) ethylenediamine salt compound has a structure as the formula II, and carboxylic acid penicillin comprises ticacillin, carbenicillin and thelike, wherein R is thiofuran-3-group or phenyl; R1, R2 and R3 are respectively independent H, alkyls of C1-C5, halogens and nitryl; and substituent groups of the substituted alkyl are selected from the halogens and alkoxy groups of C1-C5.

The invention provides a technical method for reducing a ceftazidime impurity H. The technical method is characterized in that one or more of dichloromethane, trichloromethane, carbon tetrachloride, tetrahydrofuran, acetonitrile and 2-methyltetrahydrofuran as a main solvent, tert-butyl alcohol or a mixed solvent of tert butyl alcohol and methyl alcohol is taken as a cosolvent, 7-APCA and BPTA aresubjected to a condensation reaction under the alkaline condition, ceftazidime tert-butyl ester is generated and subjected to water treatment, solvent crystallization is performed, and ceftazidime isobtained. Content of the impurity ceftazidime methyl ester (H) obtained with method in the product is smaller than 0.1%, and unknown impurities can be controlled to be 0.05% or smaller.

The invention discloses a novel-crystal-form cefathiamidine compound and a crystallization preparation method thereof. The novel-crystal-form cefathiamidine compound is prepared with a crystal product molecular assembly and form optimization technology in a particle process. The novel-crystal-form cefathiamidine compound has the characteristics of high purity, low impurity content, good flowability and good stability. Meanwhile, the invention further discloses cefathiamidine for a preparation, namely, cefathiamidine for injection, prepared from the cefathiamidine.

The invention discloses an extraction and preparation method of streptomycin sulfate. The extraction and preparation method comprises the steps of acidizing, filtering, adsorbing, pre-washing, eluting, decompression concentrating, salt forming, decoloring, concentrating and spray-drying, thus obtaining a finished product. The extraction and preparation method of the streptomycin sulfate has the beneficial effects that the technical problems in the prior art that the extraction and preparation route is long, the production efficiency is low, the investment cost is high, the yield is low, the product color is poor, and the qualification rate is low are solved and has the advantages that the extraction and preparation process is short, the procedures are simple, the production efficiency is high, the investment cost is low, the consumption of active carbon is small, the yield is high, the product color is good, and the qualification rate is high.

The invention relates to a feed for regulating and controlling duck egg quality and intestinal health of Gaoyou ducks, relating to the technical field of nutrition and regulation and control of laying ducks. The feed is prepared from colza oil, corn flour, soybean meal, salt, DL-methionine, L-lysine hydrochloride, calcium hydrophosphate, fish meal and wheat bran. The feed is characterized by further comprising fructooligosaccharide, mannan oligosaccharide, flavones, citric acid and a premix. According to the feed provided by the invention, the deposition of natural pigments in the feed in the duck eggs can be promoted, the laying rate of the laying ducks can be also increased, the feed-gain ratio is lowered, and the duck egg quality is greatly improved in comparison with that of a control group. In addition, feeding the laying ducks by using the feed is beneficial to improvement of intestinal tract development form of duodenums of the laying ducks and reduction of the quantity of harmful bacteria in ceca.

The invention discloses a method for preparing a carbon source used for synthesis of IIa type diamonds and belongs to a processing method for diamond synthesis raw materials. The method comprises the following steps: A, mixing high purity graphite with the graphite content of 99.9% or higher and diamond micro-powder together according to a ratio of (1999-1999.9):(0.1-1), and performing compression molding by using a press; B, continuously sintering the mixture obtained in the previous step for three times, wherein the primary sintering temperature is 1050-1150 DEG C, the secondary sintering temperature is 850-950 DEG C, and the tertiary sintering temperature is 750-850 DEG C. The high purity graphite with the graphite content of 99.9% or higher is mixed with the diamond micro-powder, and the mixture is subjected to three-time sintering and purification, so that the consistency and reliability of the finished carbon source are obviously improved. Moreover, the nitrogen content of the carbon source is effectively reduced, the color grade of the product is effectively improved, carburization is uniform during synthesis of IIa type diamonds, and the diamond growth surface is even.

The invention discloses a crystallization method of biapenem, which comprises the following steps of: (1) dissolving: adding crude biapenem into water (the weight ratio of biapenem to water is 1: 10), quickly heating to 40-50 DEG C, and stirring for dissolving the crude biapenem until the solution is transparent; (2) decarburization: adding 1% of activated carbon for decolorization for 10 minutes, and then filtering by using a 0.45-micron filter membrane to obtain filtrate; and (3) rapidly cooling to 10-20 DEG C, separating out biapenem crystals, then adding acetone of which the volume is 3 times that of the biapenem crystals, and further carrying out solvent-out crystallization to obtain biapenem with high purity and better color grade. The crystallization method disclosed by the invention is simple and convenient to operate, short in period and environment-friendly, the purity of the biapenem product is improved, the color grade is reduced, the quality is better, and the medication is safer.

The invention provides a preparation method of cefotaxime sodium, which is characterized in that: after protecting the active group of 7-aminocephalosporanic acid with a silylating agent, condensation reaction occurs with AE-active ester to generate cefotaxime containing protective group Xamic acid; the cefotaxime acid containing the protective group is deprotected by the deprotection agent, followed by acidification and crystallization in the aqueous phase to obtain cefotaxime acid; the cefotaxime acid is obtained after salt formation and solvent crystallization Pure sodium oxime. The entire process reduces the degradation process of the product, significantly improves the product quality, improves the market competitiveness of the product, and further guarantees the safety of medication.

The present invention relates to a synthesis method of a meropenem intermediate, in particular to a synthesis method of a novel chiral side chain of meropenem. The synthesis method of the novel chiral side chain of meropenem is characterized in that it comprises the following steps: a) using compound (I) and compound (II) as raw materials to synthesize compound (III); b) preparing compound from compound (III) (IV); c) synthesizing compound (V) from compound (IV); d) generating final product (VII) from compound (V) and compound (VI). The beneficial effects of the synthesis method of the novel chiral side chain of meropenem in the present invention are: the product has a novel structure, high optical purity, and good color grade; raw materials are cheap and easy to obtain, and the price of allyl chloroformate is lower than that of traditional p-nitrobenzyl chloroformate ; The reaction operation is simplified, and the reaction conditions are mild.

The invention discloses a diesel oxidized stabilizer composite which is prepared from the following raw materials in percentage by weight: 20-40 percent of screening phenols antioxidizer, 30-60 percent of amine antioxidizer, 10-20 percent of phosphate-contained antioxidizer, 5-10 percent of sulpho-esters antioxidizer and 5-10 percent of carboxylic acid compound. The diesel oxidized stabilizer composite can effectively reduce total insoluble substances of diesel oxidized sediments to effectively improve the color grade of the diesel. An additive for the composite has low manufacture cost, goodintersolubility with the diesel, and simple adding method without using new equipment; the additive has synergistic effect with other additions of the diesel and low solidifying point, being beneficial to winter storage and addition; moreover, the additive has the cleaning action on engines.

The invention provides a technical method for reducing a ceftazidime impurity H. The technical method is characterized in that one or more of dichloromethane, trichloromethane, carbon tetrachloride, tetrahydrofuran, acetonitrile and 2-methyltetrahydrofuran as a main solvent, tert-butyl alcohol or a mixed solvent of tert butyl alcohol and methyl alcohol is taken as a cosolvent, 7-APCA and BPTA aresubjected to a condensation reaction under the alkaline condition, ceftazidime tert-butyl ester is generated and subjected to water treatment, solvent crystallization is performed, and ceftazidime isobtained. Content of the impurity ceftazidime methyl ester (H) obtained with method in the product is smaller than 0.1%, and unknown impurities can be controlled to be 0.05% or smaller.

The invention discloses a new crystal form cefamandole nafate compound and a crystallization preparation method thereof. The new crystal form cefamandole nafate compound is prepared by adopting the particle process crystal product molecular assembling and morphology optimizing technology. The compound has the advantages of being high in purity, low in impurity content and good in fluidity and stability. The invention also discloses a preparation which is prepared from cefamandole nafate, namely cefamandole nafate for injection.

The invention discloses a ceftezole sodium compound. The ceftezole sodium compound is prepared by a molecular assembly and morphology optimization technology of a particle process crystal product. Theceftezole sodium compound has the characteristics of high purity, good color grade and good stability. The invention further discloses a preparation prepared by using the ceftezole sodium, namely ceftezole sodium for injection.

The invention discloses a method for preparing sterile cefmenoxime hydrochloride compound. The method includes: using 7-ACT.HCL which can be easily purchased at market as initial raw materials to be in condensation reaction with AE (activity ester) to generate 7-[alpha-(2-aminothianole-4-thiazolyl)-Z-2-methoxy-iminoacetamido]-3-(1-methyl-1H-5-tetrazolyl-sulfur methyl)-3-cephem-4-carboxylic acid (namely cefmenoxime sodium salt) which is further in action with 10% hydrochloric acid to generate cefmenoxime hydrochloride. The method is simple in operation, high in yield, cost-saving and stable in quality.

The invention provides an environment-friendly method for preparing an antibacterial medicine cefodizime acid with low cost. The method is characterized by comprising the steps that under the condition of taking dimethyl carbonate as a solvent, a boron trifluoride complex is adopted for catalyzing a condensation reaction of 7-aminocephalosporanic acid and 2-sulfydryl-4-methyl-5-thiazole acetic acid to obtain an intermediate 7-amidogen-3-(5-carboxymethyl-4-methyl-1,3-thiazole-2-mercapto methyl)cephalosporin-2-alkene-2-carboxylic acid, and through wet processing, the intermediate and AE active ester are subjected to direct condensation to obtain a target product. The crude cefodizime acid product produced through the method is high in content and good in color class, and the maximum impuritycontent of cefodizime sodium synthesized by the cefodizime acid can be controlled below 0.1%.