32results about How to "Improve color grade" patented technology

The invention relates to a crystallization method of cefcapene ester hydrochloride monohydrate, which belongs to the field of medicine. The method comprises the following steps: adding solvents into cefcapene ester hydrochloride for dissolution; adding active carbon for decolourization; carrying out filtration and washing; adding hydrochloric acid water solution into obtained filter liquid for carrying out crystallization; filtering crystals; respectively washing the crystals by water and ethyl acetate; and carrying out drying to obtain the cefcapene ester hydrochloride monohydrate. The method of the invention can use a single solvent of methanol for crystallization to improve the recovery yield and reduce the production cost, and can also use mixed solvents of the methanol and ketone for crystallization to improve the quality of finished product. Low-temperature active carbon is used for decolourization, and the impurity control in the operation process can be ensured at the same time of ensuring the product quality (the control on the color grade, the endotoxin and the like). The baking temperature is reduced, the baking time is shortened, and the quality such as the color grade, the impurity content and the like of the products can be reached. The invention has the advantages of simplicity, easy implementation, low cost, good crystallization clarity, good color grade and easy control on the impurities of the finished products, is suitable for large-scale popularized application, and has obvious economic benefits.

The invention relates to a feed for regulating and controlling duck egg quality and intestinal health of Gaoyou ducks, relating to the technical field of nutrition and regulation and control of laying ducks. The feed is prepared from colza oil, corn flour, soybean meal, salt, DL-methionine, L-lysine hydrochloride, calcium hydrophosphate, fish meal and wheat bran. The feed is characterized by further comprising fructooligosaccharide, mannan oligosaccharide, flavones, citric acid and a premix. According to the feed provided by the invention, the deposition of natural pigments in the feed in the duck eggs can be promoted, the laying rate of the laying ducks can be also increased, the feed-gain ratio is lowered, and the duck egg quality is greatly improved in comparison with that of a control group. In addition, feeding the laying ducks by using the feed is beneficial to improvement of intestinal tract development form of duodenums of the laying ducks and reduction of the quantity of harmful bacteria in ceca.

The invention discloses a method for preparing a carbon source used for synthesis of IIa type diamonds and belongs to a processing method for diamond synthesis raw materials. The method comprises the following steps: A, mixing high purity graphite with the graphite content of 99.9% or higher and diamond micro-powder together according to a ratio of (1999-1999.9):(0.1-1), and performing compression molding by using a press; B, continuously sintering the mixture obtained in the previous step for three times, wherein the primary sintering temperature is 1050-1150 DEG C, the secondary sintering temperature is 850-950 DEG C, and the tertiary sintering temperature is 750-850 DEG C. The high purity graphite with the graphite content of 99.9% or higher is mixed with the diamond micro-powder, and the mixture is subjected to three-time sintering and purification, so that the consistency and reliability of the finished carbon source are obviously improved. Moreover, the nitrogen content of the carbon source is effectively reduced, the color grade of the product is effectively improved, carburization is uniform during synthesis of IIa type diamonds, and the diamond growth surface is even.

The invention discloses a method for preparing cefaclor from an enzyme process. The method comprises the following steps: preparing cefaclor coarse powder from 7-amino-3-chloro-cephem acid, D-o-phenylglycine methyl ester hydrochloride, immobilized cefaclor synthetase and cefaclor crystal seed; dissolving and discoloring the cefaclor coarse powder, adding the cefaclor crystal seed to regulate the pH value, stirring for a first time to grow the grains, and stirring for a second time to grow the grains after regulating the pH value, thereby preparing a crystal mixed solution; performing the suction filtration on the crystal mixed solution to obtain a crystal product and crystallized mother liquor; and sequentially performing washing with water, soaking washing, suction filtration and vacuum drying on the crystal product to obtain cefaclor. The method for preparing cefaclor from the enzyme process has twice stirring grain-growing operation, and the cefaclor slowly separates out in a re-crystallizing process, and the prepared crystal is uniform and is better in crystalline form; and the prepared cefaclor has very high purity greater than 99.7%.

The invention provides a preparation method of cefotaxime sodium, which is characterized in that: after protecting the active group of 7-aminocephalosporanic acid with a silylating agent, condensation reaction occurs with AE-active ester to generate cefotaxime containing protective group Xamic acid; the cefotaxime acid containing the protective group is deprotected by the deprotection agent, followed by acidification and crystallization in the aqueous phase to obtain cefotaxime acid; the cefotaxime acid is obtained after salt formation and solvent crystallization Pure sodium oxime. The entire process reduces the degradation process of the product, significantly improves the product quality, improves the market competitiveness of the product, and further guarantees the safety of medication.

The invention discloses a diesel oxidized stabilizer composite which is prepared from the following raw materials in percentage by weight: 20-40 percent of screening phenols antioxidizer, 30-60 percent of amine antioxidizer, 10-20 percent of phosphate-contained antioxidizer, 5-10 percent of sulpho-esters antioxidizer and 5-10 percent of carboxylic acid compound. The diesel oxidized stabilizer composite can effectively reduce total insoluble substances of diesel oxidized sediments to effectively improve the color grade of the diesel. An additive for the composite has low manufacture cost, goodintersolubility with the diesel, and simple adding method without using new equipment; the additive has synergistic effect with other additions of the diesel and low solidifying point, being beneficial to winter storage and addition; moreover, the additive has the cleaning action on engines.

The invention provides a technical method for reducing a ceftazidime impurity H. The technical method is characterized in that one or more of dichloromethane, trichloromethane, carbon tetrachloride, tetrahydrofuran, acetonitrile and 2-methyltetrahydrofuran as a main solvent, tert-butyl alcohol or a mixed solvent of tert butyl alcohol and methyl alcohol is taken as a cosolvent, 7-APCA and BPTA aresubjected to a condensation reaction under the alkaline condition, ceftazidime tert-butyl ester is generated and subjected to water treatment, solvent crystallization is performed, and ceftazidime isobtained. Content of the impurity ceftazidime methyl ester (H) obtained with method in the product is smaller than 0.1%, and unknown impurities can be controlled to be 0.05% or smaller.

The invention discloses a method for preparing sterile cefmenoxime hydrochloride compound. The method includes: using 7-ACT.HCL which can be easily purchased at market as initial raw materials to be in condensation reaction with AE (activity ester) to generate 7-[alpha-(2-aminothianole-4-thiazolyl)-Z-2-methoxy-iminoacetamido]-3-(1-methyl-1H-5-tetrazolyl-sulfur methyl)-3-cephem-4-carboxylic acid (namely cefmenoxime sodium salt) which is further in action with 10% hydrochloric acid to generate cefmenoxime hydrochloride. The method is simple in operation, high in yield, cost-saving and stable in quality.

The invention provides an environment-friendly method for preparing an antibacterial medicine cefodizime acid with low cost. The method is characterized by comprising the steps that under the condition of taking dimethyl carbonate as a solvent, a boron trifluoride complex is adopted for catalyzing a condensation reaction of 7-aminocephalosporanic acid and 2-sulfydryl-4-methyl-5-thiazole acetic acid to obtain an intermediate 7-amidogen-3-(5-carboxymethyl-4-methyl-1,3-thiazole-2-mercapto methyl)cephalosporin-2-alkene-2-carboxylic acid, and through wet processing, the intermediate and AE active ester are subjected to direct condensation to obtain a target product. The crude cefodizime acid product produced through the method is high in content and good in color class, and the maximum impuritycontent of cefodizime sodium synthesized by the cefodizime acid can be controlled below 0.1%.