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The invention provides application of dehydrogenated silibinin diether in the preparation of medicaments for preventing and treating leukemia and relates to medical application of lignin flavone silibinin to the prevention and treatment of chronic myeloid leukemia. Particularly, the invention relates to application of dehydrogenated silibinin diether, of which the seventh bit and the twentieth bit are substituted by 1-butylene, or pharmaceutically acceptable salts thereof in the preparation of medicaments for preventing and treating chronic myeloid leukemia. Natural products of the silibinin are treated by simple steps to synthesize the compound. The pharmacological tests prove that the compound can potently inhibit the in-vitro proliferation of human chronic myeloid leukemia cell strains(K562) and adriamycin drug-resistant strains (K562 / ADR), and the IC50 values are 11.9+ / -1.6 micromoles and 15.9+ / -1.2 micromoles respectively.

The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users.

The invention relates to a method for directionally synthesizing a compound which is shown in a formula I and has a single structure through taking a compound in a formula II as a raw material. The method is characterized in that the compound in the formula II is subjected to reduction reaction through a chiral reducing agent-BINAL-H. By utilizing the method, the target product with the single structure can be obtained through one step of reaction under the condition of normal pressure, the product content can reach 95%, and the yield can reach 82%. The method is simple and practicable and has a high industrial application value.

The number of releasable licenses is registered in a first entity, the resource to be used being attributed and / or having withdrawn from it, by a second entity, a releasable license for use which is registered in the second entity and / or a license. In a synchronization step the difference between the number of licenses allocated for use since a previous synchronization step and the licenses released again in this time is repeatedly reported from the second entities to the first entity respectively, this difference being taken as a basis for reducing or increasing the number of releasable licenses registered in the first entity, and conversely the resultant number of releasable licenses is reported from the first entity to the second entity and is registered there as the number of releasable licenses.

The invention relates to a leaf surface dust fall quantity testing method based on a hyperspectral technique. The method comprises the following steps: firstly, collecting healthy leaves with different leaf surface dust fall quantities, quickly testing spectral information of a single leaf, putting the leaf subjected to the spectral information testing into a room, acquiring leaf surface dust fall quantity data of the leaf by virtue of a leaf area instrument and an electronic scale, and determining a sensitive spectral band subjected to leaf surface dust fall by analyzing the correlation between hyperspectral information and the leaf surface dust fall quantity data; and carrying out modeling by virtue of the data of the sensitive spectral band subjected to the leaf surface dust fall, selecting a model with a minimal root-mean-square error and maximal errors between a determination coefficient and a predicted root-mean-square error and between a sample standard deviation and the predicted root-mean-square error, and predicting the leaf surface dust fall quantity of the model only by virtue of the hyperspectral information of the leaf. Compared with a traditional determination method, the leaf surface dust fall quantity testing method has the beneficial effects of reducing the tedious experimental steps of indoor leaf area testing, cleaning, weighing and the like, being simple, convenient and rapid, and meanwhile, providing references for monitoring of the sand storm strength and environment quality of a dust fall region by virtue of astronautic hyperspectral remote sensing.

The invention discloses a method for separating and extracting L-glufosinate from enzymatical reaction liquid. When an enzyme catalysis method is adopted for producing the L-glufosinate, enzyme catalysis liquid contains not only the L-glufosinate, but also impurities including enzyme or thalli, byproducts(normally organic matters), unreacted D-type substrates, ammonium salt and the like, and due to the fact that the L-glufosinate has such characteristics as being soluble in water and insoluble in organic solvent, separation and extraction difficulty levels are high; the method for separating and extracting the L-glufosinate mainly includes the following three steps of (1) pre-treatment, (2) an ion exchange method and (3) crystallization; the purity of the product finally obtained reaches 98% or above, and the yield reaches 98% or above. According to the method, the technological process is short, operation is simple, the application range is wide, the cost is low, the yield of the L-glufosinate is high, and the product quality is high.

The invention relates to a new method for preparing drospirenone (6 beta, 7 beta; 15 beta, 16 beta- dimethylene-3-oxo-17 alpha- pregna-4-alkene-21, 17- carboxyl lactone) and an intermediate product obtained by the method, that is, 3- androstane protected by hydroxy group-5- alkene-15 beta, 16 beta- methylene-17-ketone. The invention uses the 3- androstane protected by hydroxy group-5- alkene-15 beta, 16 beta-methylene-17-ketone being available in the market as the starting material, which forms loop coils by the steps such as the hydroxy group protection, addition, hydrolysis, oxidation, and finally forms triatomic ring to prepare the drospirenone.

The invention discloses a method for preparing Roflumilast. The method comprises the following steps of: performing cyclopropyl methylation on isovanillin to obtain 3-cyclopropylmethoxy-4-methoxybenzaldehyde; performing demethylation to synthesize an important intermediate of the Roflumilast, namely 3-cyclopropylmethoxy-4hydroxyl-benzaldehyde; and further synthesizing a key intermediate in a formula (5) according to American patent US5712298 and finally synthesizing the Roflumilast in a formula (7). A crude product of the Roflumilast is treated by isopropanol and water, and is recrystallized by ethyl acetate and petroleum ether. The preparation method has a few steps, raw materials are readily available and cheap, the reaction selectivity is high, the yield is high and the post treatment is simple.

A web of a polymer film (1) is coated with an oxide layer, in particular with an SiOx barrier layer, by transporting the web with the aid of a rotatable drum (12) through a plurality of flame bands, which are directed in a radial direction from above against the circumferential surface of the drum, which extend at a distance from each other across the width of the web being supported and transported on this circumferential surface, and which are fed with a gas mixture including a combustible gas, an oxidant, and a silicon containing compound. Therein the circumferential surface of the rotatable drum is cooled to a predetermined temperature and the web is transported through the area of the tip of the inner flame region. Polymer films with barrier layers produced in the named way have at small layer thicknesses of less than 10 nm very good barrier properties.

The invention belongs to the field of pharmacy and relates to a method for preparing cefazolin compounds. The method comprises the following steps that: 1, cefazolin sodium imidazo (toluene diamine TDA) is synthetized, thiadiazole and 7-ACA are obtained through reaction, dimethyl carbonate is used as solvents in the reaction, boron trifluoride-dimethyl carbonate is used as catalysts, and reagents used for regulating the pH of the reaction liquid are inorganic alkali after the reaction is completed; 2, anhydride is prepared, and the anhydride is obtained through the reaction between tetrazole acetic acid and pivaloyl chloride, and 3, the cefazolin is synthesized, TDA solution reacts with the anhydride, and the reaction solution is subjected to decoloration and purification through an aluminium oxide column.

The invention discloses a synthetic method of 1,1,1,4,4,4-hexafluoro-2-butene, and the synthetic method comprises the steps of carrying out a reaction between hexachlorobutadiene and hydrogen fluoride in the presence of a catalyst to generate 1,1,1,4,4,4-hexafluoro-2,3-dichlorobutane, and carrying out a reductive dechlorination reaction on the 1,1,1,4,4,4-hexafluoro-2,3-dichlorobutane in a solvent by using zinc powder to generate the 1,1,1,4,4,4-hexafluoro-2-butene. According to the synthetic method, the process is simple, the steps are short, the reaction conditions are mild and the product can be obtained through two steps of reaction; and the raw materials are easy to get, the cost is low, and the byproduct hexachlorobutadiene obtained by reducing tetrachloroethylene by carbon tetrachloride at high temperature can be used as a raw material, so that the cost is further reduced.

Color filters can each be fabricated by printing a pixel pattern for the color filter on a flexible plastic film by a central impression cylinder press. The pixel pattern is formed of pixels of three primary colors consisting of red, green and blue or pixels of three primary colors consisting of yellow, magenta and cyan. Also disclosed are inks, color filters, and image displays using the color filters.

The invention discloses a preparation method for 2-chloro-1,1,1,4,4,4-hexafluoro-2-butene. The preparation method is as follows: mixing a catalyst, hydrogen fluoride and hexachlorobutadiene in a molar ratio of (0.01-0.3):(5-50):1, then, heating to 30-250 DEG C for reacting for 3-12 hours while controlling the reaction pressure to 0.1-3.0Mpa, and cooling, layering, washing, alkaline-washing and rectifying to obtain a product after the reaction is ended. The preparation method disclosed by the invention has the advantages of being simple in process, high in yield, easy in obtaining of materials and gentle in reaction condition.