45 results about "Ceftezole Sodium" patented technology

The invention belongs to the technical field of medicine, and particularly relates to a ceftezole sodium compound and a medicinal preparation including the same. The ceftezole sodium compound is ceftezole sodium trihydrate, and the structural formula is shown in the specification. An X-ray powder diffraction pattern, obtained through Cu-K alpha ray measurement, of the ceftezole sodium compound is shown as picture 1. A sterile powder-injection is adopted as the preparation including the ceftezole sodium compound. The content of polymer in the ceftezole sodium compound is low, and is almost not changed during an acceleration test and a long-term test. After a ceftezole sodium sterile power needle manufactured through the ceftezole sodium compound is combined with the five-percent glucose injection, the relative content of ceftezole sodium is hardly changed, and compatible stability is good.

The invention discloses a type I ceftezole sodium crystal and a preparation method thereof. The preparation method is characterized by comprising the following steps of mixing sodium salt solution with ceftezole acid to obtain an aqueous solution of ceftezole sodium, decolorizing with activated carbon and filtering; dropping the aqueous solution of ceftezole sodium in mixed solution of organic solvent I and water by stirring; when needle-like precipitates are found, reducing the stirring rotating speed and growing the crystal at room temperature; continuously dropping the organic solvent I and organic solvent II, growing the crystal at low temperature and raising the stirring rotating speed; filtering, flushing the crystal with the mixed solution of the organic solvent I and the water and performing vacuum drying to obtain the type I ceftezole sodium crystal. According to the preparation method for the type I ceftezole sodium crystal, provided by the invention, the single type I ceftezole sodium crystal with the advantages of high purity, high thermal stability, homogeneous particles and good inter-batch repeatability can be obtained, and important significance for improving the stability and the safety of the ceftezole sodium for injection is realized; in addition, the preparation method has the advantages of simple operation, easiness in control for conditions and suitability for batch production.

The invention relates to a ceftezole sodium compound and a novel method thereof. The method provided by the invention achieves the refining aim by acidification reaction, activated carbon adsorption, electroosmosis device processing and preparation of chromatographic columns, so as to finally obtain a high-purity ceftezole sodium compound, overcomes the defects of low purity of the existing raw materials, improves the product quality of the preparation, reduces the toxic and side effects, and ensures the clinical safety of the medicine at the same time.