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Preparations containing ceftezole sodium

A technology of ceftezole sodium and aerosol, which is applied in the field of aerosol containing ceftezole sodium, can solve the problems of inconvenient administration of ceftezole sodium, and achieve good hygroscopicity, improved stability, and good sprayability Effect

Inactive Publication Date: 2017-01-04
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention in order to solve the shortcoming of existing ceftezole sodium administration inconvenience, invented ceftezole sodium aerosol

Method used

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  • Preparations containing ceftezole sodium
  • Preparations containing ceftezole sodium
  • Preparations containing ceftezole sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Ceftezole Sodium: 5 parts

[0025] Ethanol: 450 parts

[0026] Polysorbate 40:8 parts

[0027] Lauryl alcohol: 5 parts

[0028] f 12 : 550 copies.

[0029] Preparation:

[0030] (1) dissolve ceftezole sodium with ethanol to obtain a clear and uniform solution;

[0031] (2) take polysorbate 40 and lauryl alcohol of recipe quantity respectively, add in the above-mentioned solution, make solution system;

[0032] (3) Put the solution obtained in step (2) into the container, install the valve and tighten it, and press the propellant F 12 , Shake well to get an aerosol.

Embodiment 2

[0084] Embodiment 2 Ceftezole Sodium Aerosol Accelerated Test

[0085] Accelerated test: Get the samples of Ceftezole Sodium Aerosol of the present invention Example 1 and Comparative Examples 1-8, place in DHS-100 constant temperature and humidity chamber (Beijing Yashilin Experimental Equipment Co., Ltd.), adjust the temperature to 40°C , relative humidity is 75%, respectively sampling once in 1,2,3,6 months, detects ceftezole sodium content (percentage by weight), the results are shown in Table 1.

[0086]Table 1 Accelerated test results of ceftezole sodium aerosol

[0087] Table 1 Accelerated test results

[0088]

[0089]

[0090] As can be seen from Table 1, the stability of the aerosol of Example 1 is the best, no matter changing the aerosol adjuvant or the dosage, all can significantly reduce the stability of the ceftezole sodium aerosol.

Embodiment 3

[0091] Example 3 Ceftezole Sodium Aerosol Room Temperature Sample Observation Result

[0092] According to Chinese Pharmacopoeia 2000 edition two, carry out visual observation and analysis of aerosol, the results are shown in Table 2.

[0093] Table 2

[0094]

[0095] According to Table 2, it can be seen that the aerosol prepared by ethanol solution is the most stable, and the aerosol solution prepared with polysorbate 40 and lauryl alcohol as co-solvents has the best sensory in all aspects.

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Abstract

The invention relates to ceftezole sodium spray. The ceftezole sodium spray is prepared from the following components in parts by weight: 5 parts of ceftezole sodium, 450 parts of ethanol, 408 parts of polysorbate, 5 parts of laurinol, and 50 parts of F125.

Description

technical field [0001] The present application relates to an aerosol, specifically, an aerosol containing ceftezole sodium. Background technique [0002] Ceftezole sodium, also known as Yitixin, its chemical name is: (6R,7R)-3-[(1,3,4-thiadiazol-2-yl)thiomethyl]-8-oxo- 7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate sodium, English alias: 5-Thia- 1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic sodium or sodium(6S,7R)-8-oxo-7-[(1H-tetrazol-1-yacetyl)amino]-3-[ (1,3,4-thiadiazol-2-ylsulf anyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. This product is white to light yellow crystalline powder, odorless and hygroscopic. Ceftezole sodium is a semi-synthetic cephalosporin derivative, and its mechanism of action is to exert antibacterial activity by inhibiting the synthesis of bacterial cell walls. Ceftezole sodium has antibacterial activity against the following bacteria: Aerobic Gram-positive bacteria: Staphylococcus aureus, Strept...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K9/12A61P31/04
Inventor 牛敬媛张彬王帅赵杉闫晓晓王海涛
Owner XINXIANG MEDICAL UNIV
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