Treatment method of ceftazidime mother liquid

Abstract

The invention discloses a treatment method of ceftazidime mother liquid, and belongs to the technical field of medicine. The method comprises the step that ceftazidime mother liquid is subjected to freezing treatment at -1 to -21 DEG C. By the treatment method, ceftazidime concentrated mother liquid with high ceftazidime content is obtained; the COD discharged by the mother liquid is reduced; ceftazidime solid powder with high purity can also be obtained; the recovered ceftazidime concentrated mother liquid returns to an upstream process for use indiscriminately; the utilization rate of the ceftazidime mother liquid is improved. The treatment method also has the advantages that the quality of the recovered product is stable; the recovery method is simple; the recovery cost is low.

Description

technical field [0001] The invention relates to concentration and recovery of mother liquor, in particular to a method for concentrating mother liquor and recovering active ingredients in the antibiotic preparation process, belonging to the technical field of medicine. Background technique [0002] Ceftazidime is a third-generation cephalosporin antibiotic created by GlaxoSmithKline, which has a strong effect on Gram-positive or negative bacteria. Pseudomonas aeruginosa, Escherichia coli, Klebsiella, Proteus, Enterococcus, Salmonella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus, hemolytic streptococcus, pneumococcus and other Aerobacter has strong antibacterial activity, especially for Pseudomonas aeruginosa, ceftazidime is the most effective antibiotic, and its medicinal injection is a sterile mixture of ceftazidime pentahydrate and sodium carbonate or arginine. [0003] At present, there are two different methods for the preparation of c...

AI Technical Summary

Problems solved by technology

[0004] No matter which synthetic route is adopted, the final crystallization purification method is to dissolve and crystallize ceftazidime hydrochloride. The pH regulator used in the crystallization process is generally phosphoric acid solution, sulfuric acid solution or dihydrogen phosphate solution. The primary crystallization yield of ceftazidime is only About 85%, there are about 15% in the mother liquor, which not only increases the production cost of ceftazidime, if it is discharged directly, it will cause certain economic losses and higher environmental protection costs

[0005] Patent document CN101774709A discloses a treatment method for ceftazidime mother liquor, which is a treatment method for concentrating and separating ceftazidime mother liquor using membrane separation technology. This method needs to purchase membrane separation equipment, which is expensive, and the solvent tolerance of the membrane is weak. Residual organic solvents are extremely destructive to the membrane, resulting in increased costs; the patent document CN107722040A discloses a membrane separation method and device for recycling ceftazidime mother liquor, which also has the above-mentioned problems of high price and easy damage to the membrane

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