Treatment method of ceftazidime mother liquid

A ceftazidime and treatment method technology, which is applied in the field of medicine, can solve the problems of increasing the production cost of ceftazidime, economic loss, easy damage of the membrane, etc., and achieve the effect of stable quality of recovered products, simple treatment method and simple recovery method

Active Publication Date: 2018-12-11
NORTH CHINA PHARMA HEBEI HUAMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] No matter which synthetic route is adopted, the final crystallization purification method is to dissolve and crystallize ceftazidime hydrochloride. The pH regulator used in the crystallization process is generally phosphoric acid solution, sulfuric acid solution or dihydrogen phosphate solution. The primary crystallization yield of ceftazidime is only About 85%, there are about 15% in the mother liquor, which not only increases the production cost of ceftazidime, if it is discharged directly, it will cause certain economic losses and higher environmental protection costs
[0005] Patent document CN101774709A discloses a treatment method for ceftazidime mother liquor, which is a treatment method for concentrating and separating ceftazidime mother liquor using membrane separation technology. This method needs to purchase membrane separation equipment, which is expensive, and the solvent tolerance of the membrane is weak. Residual organic solvents are extremely destructive to the membrane, resulting in increased costs; the patent document CN107722040A discloses a membrane separation method and device for recycling ceftazidime mother liquor, which also has the above-mentioned problems of high price and easy damage to the membrane

Method used

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  • Treatment method of ceftazidime mother liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 200mL of ceftazidime mother liquor, the content of ceftazidime in the mother liquor is 25.71mg / mL, add 0.5g of activated carbon, stir at 10°C for 20 minutes to decarburize, and then carry out freezing treatment. The specific freezing process is to freeze at -4°C for 1 hour, and continue to cool down to Freezing at -6°C for 1 hour, part of the mother liquor was frozen into a solid, and the 120 mL of unfrozen liquid was the concentrated mother liquor. The concentrated mother liquor was tested and the content of ceftazidime was found to be 31.47 mg / mL.

Embodiment 2

[0033] Take 200mL of ceftazidime mother liquor, the content of ceftazidime in the mother liquor is 16.74mg / mL, add 0.3g of activated carbon, stir at 10°C for 30 minutes to decarburize, and then carry out freezing treatment. The specific freezing process is to freeze at -1°C for 1 hour, and then continue to cool down to Freeze at -5°C for 1 hour, continue to cool down to -6°C for 1 hour, part of the mother liquor freezes into a solid, and the unfrozen 110mL liquid is the mother liquor after concentration. The mother liquor after concentration is tested, and the content of ceftazidime is found to be 22.30 mg / mL.

Embodiment 3

[0035] Take 200mL of ceftazidime mother liquor, the content of ceftazidime in the mother liquor is 13.86mg / mL, add 0.3g of activated carbon, stir at 20°C for 40 minutes to decarburize, and then carry out freezing treatment. The specific freezing process is to freeze at -2°C for 1 hour, and then continue to cool down to Freeze at -3°C for 1 hour, freeze at -6°C for 1 hour, part of the mother liquor freezes into a solid, and the unfrozen 130mL liquid is the concentrated mother liquor. The concentrated mother liquor is tested and the content of ceftazidime is 18.10mg / mL.

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Abstract

The invention discloses a treatment method of ceftazidime mother liquid, and belongs to the technical field of medicine. The method comprises the step that ceftazidime mother liquid is subjected to freezing treatment at -1 to -21 DEG C. By the treatment method, ceftazidime concentrated mother liquid with high ceftazidime content is obtained; the COD discharged by the mother liquid is reduced; ceftazidime solid powder with high purity can also be obtained; the recovered ceftazidime concentrated mother liquid returns to an upstream process for use indiscriminately; the utilization rate of the ceftazidime mother liquid is improved. The treatment method also has the advantages that the quality of the recovered product is stable; the recovery method is simple; the recovery cost is low.

Description

technical field [0001] The invention relates to concentration and recovery of mother liquor, in particular to a method for concentrating mother liquor and recovering active ingredients in the antibiotic preparation process, belonging to the technical field of medicine. Background technique [0002] Ceftazidime is a third-generation cephalosporin antibiotic created by GlaxoSmithKline, which has a strong effect on Gram-positive or negative bacteria. Pseudomonas aeruginosa, Escherichia coli, Klebsiella, Proteus, Enterococcus, Salmonella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus, hemolytic streptococcus, pneumococcus and other Aerobacter has strong antibacterial activity, especially for Pseudomonas aeruginosa, ceftazidime is the most effective antibiotic, and its medicinal injection is a sterile mixture of ceftazidime pentahydrate and sodium carbonate or arginine. [0003] At present, there are two different methods for the preparation of c...

Claims

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Application Information

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IPC IPC(8): C07D501/12C07D501/46
CPCC07D501/12C07D501/46
Inventor 贾全刘树斌田洪年石春利李庆伟张锁庆任峰魏宝军于亚南
Owner NORTH CHINA PHARMA HEBEI HUAMIN PHARMA
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