Ceftazidime medicinal composition for injection and preparation method thereof

Abstract

The invention relates to a ceftazidime medicinal composition for injection and a preparation method thereof. The ceftazidime medicinal composition for injection comprises the following components in part by weight: 1 part of ceftazidime, 0.05 to 0.5 part of arginine and 0.0001 to 0.001 part of antioxidant. The ceftazidime medicinal composition for injection provided by the invention has the advantages of good dissolubility, good quality, stable color and luster and low polymer content, and the polymer content cannot be increased due to the increment of storage time, so that the medication safety is improved.

Description

technical field The invention belongs to the field of preparations, in particular to a ceftazime pharmaceutical composition for injection and a preparation method thereof. Background technique Ceftazidime is a third-generation cephalosporin antibiotic with strong antibacterial activity and broad antibacterial spectrum, and has strong effects on Gram-positive or negative bacteria. It is highly stable to the β-lactamase produced by Gram-positive bacteria and negative bacteria. This product is effective against Pseudomonas aeruginosa, E. Neisseria, Neisseria meningitidis, Staphylococcus aureus, hemolytic streptococcus, pneumococcus and Bacillus aerogenes have strong antibacterial activity. Ceftazidime is suitable for respiratory tract infection, urinary tract infection, skin and soft tissue infection, gastrointestinal, biliary tract and abdominal infection, bone and joint infection, complicated infection caused by dialysis, infection prevention and treatment of various operati...

AI Technical Summary

Problems solved by technology

However, ceftazidime, normal saline, and 5% glucose solution are all slightly acidic, so ceftazidime using sodium carbonate as a cosolvent will produce CO when diluted. 2 Gas, if the exhaust operation is improper, it may contaminate the liquid medicine, such as CO during infusion 2 Dissolution produces air bubbles, which may cause gas embolism to enter the patient's blood. If the blockage occurs in the main blood vessels of the heart and brain, it will cause great danger to the patient.

(3) Ceftazidime is unstable in sodium bicarbonate solution

At present, most of the research on the solubility of ceftazidime in the market has no good solution to the problems of ceftazidime color, degradation, polymerization and stability. Color stable ceftazidime formulation

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