388results about How to "Has antibacterial activity" patented technology

The invention discloses a magnetic graphene oxide nanometer compound, a preparation method and application thereof. The magnetic graphene oxide nanometer compound comprises graphene oxide, and the surface of graphene oxide is loaded with iron oxides magnetic nanometer particles. The preparation method comprises preparation of a graphene oxide dispersion liquid, preparation of an iron oxides magnetic nanometer particle dispersion liquid and preparation of the magnetic graphene oxide nanometer compound. The magnetic graphene oxide nanometer compound is applicable to water sterilization. The magnetic graphene oxide nanometer compound disclosed by the invention is excellent in antibacterial performance, efficient and easy to separate, the preparation method is simple and low in cost, the water sterilization processing effect is good, disinfection by-products is not easy to generate and secondary pollution is not easy to cause.

The present invention relates to one kind of sodium-potassium andrographolide-semisuccinate and its preparations. On the basis of potassium andrographolide-semisuccinate, which is not enough stable and is likely to produce precipitate and negative effect, sodium-potassium andrographolide-semisuccinate is developed and has relatively high stability and less side effect. The sodium-potassium andrographolide-semisuccinate is prepared into injection, powder for injection and other forms.

The invention relates to an artificial dermis bracket. The artificial dermis bracket comprises a three-dimensional porous structure with a deep layer and a shallow layer, wherein sustained release microspheres loaded with functional factors are introduced into the artificial dermis bracket, and comprise microspheres loaded with antibiotics and microspheres loaded with skin growth factors, and a gradient structure is formed by the three-dimensional porous structure of the artificial dermis bracket due to different porosities of the deep layer and the shallow layer. The preparation method of the artificial dermis bracket mainly comprises the steps of: preparing the sustained release microspheres loaded with the functional factors; preparing collagen solutions with two concentrations as matrix solutions; and mixing the sustained release microspheres loaded with the functional factors into the corresponding matrix solutions and molding the three-dimensional porous structure comprising the deep layer and the shallow layer so as to form the artificial dermis bracket with introduction of the sustained release microspheres loaded with the functional factors. The artificial dermis bracket provided by the invention has antibacterial activity and the property of promoting wound healing.

The invention discloses a multipurpose product capable of improving in-vivo and in-vitro metabolism of body skin, whitening the skin and resisting ageing. The multipurpose product consists of high-purity medical ionized water, far infrared extracts, negative oxygen ion extracts, pearl powder, aloe extracts, borneol, herba manthae heplocalycis, catenella opuntia grev extracts, seaweed caviar, guava extracts, echinacea extracts, loofah extracts, mycose, hydrolyzed collagen, hydrolyzed malt extracts, algae extracts, sodium hyaluronate, carbomer, aloe enzymes, cucumber enzymes and camu enzymes, is in the state of emulsion or gel and is named as an agent A for short. Sodium bicarbonate and potato starch form powder which is named as an agent B for short. The far infrared extracts, the negative oxygen ion extracts, traditional Chinese medicines, the algae extracts and carbonic acid ingredients which are packaged independently and are combined freely are added in the product creatively, the blood flow volume of capillary vessels on the surface of the skin can be increased effectively, moisturizing metabolism is promoted, wrinkles are smoothed out, and the skin of a user can be tender, smooth and willowy.

The invention relates to citrus endophytic actinomycetes with antibacterial activity on various plant pathogens, belonging to the technical field of microbes. The endophytic actinomycetes are Streptomyces sp. R1020 which was registered and collected in China General Microbiological Culture Collection Center on March 17, 2014 with the collection number of CGMCC No. 8923. The strain R1020 has relatively good inhibitory effect on citrus anthrax bacteria, citrus bacterial canker disease bacteria, citrus penicillium italicum, citrus penicillium digitatum, bayberry deadwood disease bacteria, bayberry acicola, bayberry anthrax bacteria, loquat anthrax bacteria, loquat leaf spot fungi, loquat ringspot pathogenic bacteria, tomato alternaria solani, botrytis cinerea, colletotrichum orbiculare, tea tree anthrax bacteria and elsinoeleucospila and has the potential of being developed into biological pesticides.

The invention discloses a chitosan / nano-TiO2 composite material and a preparation method and application thereof. The preparation method comprises the following steps that a chitosan solution is mixed with nano-TiO2 powder, the chitosan solution and the nano-TiO2 powder are dispersed by ultrasonic waves and reacted at a temperature of 160-180 DEG C for 1-2h to obtain the chitosan / nano-TiO2 composite material, wherein the concentration of the chitosan solution is 0.05 to 0.2 g / L, and the addition amount of the nano-TiO2 powder is 0.1 to 1.0g / L. The preparation method provided by the invention is simple to operate and good in safety, and nano-TiO2 can be uniformly dispersed in chitosan. The chitosan / nano-TiO2 composite material prepared by the method has a stable structure, better mechanical properties and processing properties, and can be used for preparing a fiber material; and the composite material can effectively decompose exopolysaccharides of rice bacterial blight pathogens, has antibacterial activity against the rice bacterial blight pathogens, and high photocatalytic efficiency, and is used for rice cultivation to effectively prevent and treat the rice bacterial blight.

The invention discloses a preparation method for peanut bioactive peptide. The method comprises the following steps: adding peanut protein powder to distilled water, carrying out stirring, followed by standing and microwave treatment to obtain peanut protein powder suspension liquid; adjusting a pH value of the peanut protein powder suspension liquid through a hydrochloric acid solution, then adding compound plant hydrolase Viscozyme L, followed by carrying out the microwave treatment to secondarily carry out enzymolysis to obtain a enzymatic hydrolysate, then killing the enzymes and carryingout cooling to a room temperature; adjusting a pH value of the enzymatic hydrolysate through a sodium hydroxide solution or the hydrochloric acid solution, then adding protease and carrying out the microwave treatment to secondarily carry out the enzymolysis, then killing the protease and carrying out cooling to the room temperature, followed by carrying out centrifugating and freeze drying to obtain the peanut bioactive peptide. The prepared peanut bioactive peptide product provided by the present invention has functional properties of high dissolubility, high emulsibility, strong foamability, good emulsion stability, good foam stability and the like. In addition, the method provided by the present invention is applicable for the industrial production.

The invention belongs to the technical field of genetic engineering and particularly relates to a bovine-derived anti-staphylococcus aureus genetic engineering single-chain antibody, a preparation method and application thereof. The single-chain antibody comprises a bovine antibody light-chain variable region VL, an intermediate junction peptide Linker and a bovine antibody heavy-chain variable regional VH, the connecting sequence thereof is VL-Linker-VH. The amino acid sequence of the bovine antibody light-chain variable region VL is shown as SEQ ID No: 1-8. The amino acid sequence of the bovine antibody heavy-chain variable region VH is shown as SEQ ID No: 9-16. The screened single-chain antibody (scFv) of positive clone is jointly applied to in-vitro and in-vivo inhibition staphylococcus aureus test and achieves ideal antibacterial effect. The single-chain antibody is used for preparing drugs for preventing and curing staphylococcus aureus bovine mastitis.

The invention discloses natural handmade soap with an acne removing function and a preparation method of the natural handmade soap. The natural handmade soap is prepared from the following raw materials in percent by weight: 0.2%-1.2% of a lithospermum alcohol extract, 0.5%-1.8% of a salvia alcohol extract, 0.2%-0.8% of borneol, 0.5%-2% of dipotassium glycyrrhizinate, 0.3%-0.6% of tea tree essential oil, 0.8%-4% of natural plant oil, 5%-25% of glycerinum, 0.1%-0.5% of hyaluronic acid and 70%-88% of sodium aliphatate. The medicinal compositions, namely the lithospermum extract and the salvia extract, in the formula have good acne removing and spot fading effects; the borneol has the effects of clearing away heat and toxic materials, preventing corrosion and promoting granulation; and the dipotassium glycyrrhizinate has anti-inflammatory and anti-allergic effects, and is matched with the tea tree essential oil which has antibacterial activity and an excellent skin penetration enhancing effect, so that the prepared handmade soap has the acne removing effect while cleaning the skin. The invention further provides the preparation method of the natural handmade soap.

The invention discloses a method for producing a functional microbial fermented feed. The method uses soybean meal, fulvic acid powder, corn syrup powder, wheat bran, rice bran powder and Chinese herbal medicines including Sichuan phellodendron bark powder, powder of coptidis roots from Sichuan of China, scutellaria root powder, astragalus root powder, and isatis root powder as fermentation raw materials, and uses bacillus subtilis, bacillus licheniformis, lactococcus lactis, and brewer's yeast mud as beneficial microbial flora. The seed liquids of bacillus subtilis, bacillus licheniformis andlactococcus lactis, and the brewer's yeast mud are mixed with the fermentation raw materials in proportion, and the mixture is subjected to four stages including aerobic fermentation, anaerobic fermentation, sterile air fermentation and anaerobic fermentation to obtain the functional microbial fermented feed. The product of the invention is rich in nutrients, has good attracting property, and good disease resistance and disease prevention effects, and obviously promotes the growth effect of cultured animals. At the same time, the functional microbial fermented feed can also improve the breeding environment and purify water, and is a green, safe and efficient functional microbial fermented feed.

Compounds of formula (I) have antibacterial activity wherein R represents hydrogen or 1, 2 or 3 optional substituents; W is =C(R1)- or =N-; R1 is hydrogen or an optional substituent and R2 is hydrogen, methyl, or fluorine; or R1 and R2 taken together are -CH2-, -CH2CH2-, -O-, or, in either orientation, -O- CH2- Or -OCH2CH2-; R3 is a radical of formula -(Alk<1>)m-(Z)p-(Alk<2>)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z is -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, -N(CH2CH3)-, -C(=O)-, -O-(C=O)-, -C(=O)-O-, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic heterocyclic radical having 5 to 10 ring atoms; Alk<1> and Alk<2> are optionally substituted C1C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, or -N(CH2CH3)-; and Q is hydrogen, halogen, nitrile, or hydroxyl or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic heterocyclic radical having 5 to 10 ring atoms.

The invention relates to a horticultural crop composite biological nutrient medium which comprises a substrate, and microalgae and a culture fluid thereof. The horticultural crop composite biological nutrient medium is characterized by comprising the following components in percentage by mass: 1.5-5.5% of sodium alginate, 0.5-3.5% of chitosan, 0.5-5.5% of polyacrylamide, 1-5% of sodium carboxymethyl cellulose, 5-20% of shell powder and 60.5-91.5% of clay. The microalgae are fresh water Chlorella which can be autotrophic, heterotrophic or mixedly cultured after being cultured to later exponential growth phase, the concentration is greater than or equal to 3.0*10<6>cell / ml, and the addition amount is preferably sufficient in the substrate without flowing. The invention has the effects of moisture retention, nutrient slow release and soil improvement; most materials are aquiculture byproducts, thereby changing wastes into valuable substances and having obvious environmental protection effect; and the nutrient medium can be completely degraded within 3-5 years, and can not have permanent damage on soil. The microalgae reserved in the soil can have an active effect on the soil, increase the soil fertility and improve the physical and chemical properties of the soil.

The invention discloses a method for preparing natural sunscreen and skin whitening components in cosmetics by utilizing fruits. Fruits sold on the market are cleaned twice with tap water; after the fruits are diced and weighed, carbohydrate which accounts for 5-30% the weight of the fruits and water which accounts for 1-3 times the weight of the fruits are added to completely dissolve sugar; the solid-liquid mixture is placed in a sterile fermentation tank and is subjected to controlled temperature fermentation for 90 days at room temperature of 20-39 DEG C; unsealing is performed after a fermentation period is due, and fermentation stock solutions are filtered and extracted in a sterile chamber. After the fermentation stock solutions undergo sterility detection, the fermentation stock solutions of different fruits are used independently or mixed proportionally, and natural perfume is added; and after the sterile test of the fermentation stock solutions is passed, filling is performed to obtain sunscreen components of the cosmetics. The sunscreen components are prepared by natural fermentation of fruit plants, and the sunscreen components have no artificial color and chemical functional components and have no adverse irritation to the skin.

The invention discloses a soapberry liquid composition which comprises the following components in parts by weight: 3-8 parts of soapberry saponin rhamnolipid fermentation refined matters, 2-6 parts of soapberry saponin lactic acid fermentation refined matters, 3-5 parts of Chinese honey locust saponin alcohol fermentation refined matters, 0.02-0.5 part of Lipolase, 0.01-0.3 part of pectinase, 0.2-0.5 part of sodium chloride, 0.5-3 parts of sodium citrate and 70-90 parts of water. According to the invention, the fermentation refined matters substitute soapberry or Chinese honey locust extracting liquor, so that impurities such as saccharides and proteins in the extracting liquor can be converted into useful components of the detergent, and the stability of liquid products can be greatly improved at the same time; soapberry saponin lactic acid fermentation refined matters are complex of the saponin and a biological surfactant rhamnolipid, so that the defect that the surface activity of the soapberry saponin is worse than that of a synthesized surfactant is effectively overcome.

The invention provides a preparation method for climbing nightshade extract which comprises, steeping medicinal powders with edible ethanol, decompression reclaiming ethanol and compensating the soak, charging natural clarifying agent so as to precipitate the impurity, finally drying the filtered clean liquid into block-shaped solid extract, wherein the major component of the extract is steroidal alkaloid with anti-inflammation action, which can be prepared into electuary for treating eczema and fungus skin diseases.

The invention provides bacillus amyloliquefaciens for biocontrol and application thereof. The preservation number of the bacillus amyloliquefaciens in the China General Microbiological Culture collection center is CGMCC No.12742. The bacillus amyloliquefaciens can be used for preparing antibiological inoculants and bacterial manure aiming at plant pathogenic fungi and pathogenic bacteria. The bacillus amyloliquefaciens has high bacteriostatic activity on the bacteriostatic activity and the pathogenic bacteria, and has a wide antimicrobial spectrum.

The invention relates to an antibacterial laundry detergent and application thereof. The antibacterial laundry detergent is composed of, by weight percentage, 0.1-1.0% of silver nanoparticles and 13.0-30.0% of surfactant, wherein the surfactant is a mixture of anionic surfactant and nonionic surfactant, the anionic surfactant is composed of fatty alcohol-polyoxythylene ether sodium sulfate, alpha-sodium alkenyl sulfonate and potassium aliphatate, and the nonionic surfactant is fatty alcohol-polyoythylene ether. The antibacterial laundry detergent also comprises acrylic polymers and other auxiliaries such as bio-enzymes, enzyme stabilizer, chelating agent and fragrance. The antibacterial laundry detergent has the advantages of being clean in washing, easy to rinse, antibacterial, anti-static, soft, good in color preservation and environmentally friendly.

The invention discloses antibacterial monomer-containing repairing composite resin for dentistry and a preparation method thereof. The composite resin comprises 1-25% of bisphenol A-glycidyl methacrylate, 1-20% of carbamic acid ester dimethacrylate, 4-15% of triethylene glycol dimethacrylate, 1-10% of methylacryloyl oxygen dodecylpyridinium bromide, 55-80% of silicon dioxide, 0.5-1% of camphorquinone and 0.5-1% of N, N-dimethylamino ethyl methacrylate. The methylacryloyl oxygen dodecylpyridinium bromide in the composite resin is an antibacterial bonding monomer synthesized from antibacterial quaternary ammonium dodecylpyridine and polymerizable methylacryloyl groups and can be polymerized with other monomers, so that the composite resin has an antibacterial effect, and the bonding effect between the resin and teeth can be enhanced.

The invention discloses a quick cultivation method for macadimia nut seedlings. The method comprises the steps that a branch, which grows in the current year, has at least three rings of leaves and is 20 cm or above long, of a macadimia nut tree is selected, the branch to be sheared is scratched at the beginning of March, the base of the branch is girdled in the middle ten days of March, the branch is sheared off perpendicularly from the base in the first or middle ten days of April, a cut is made round, a protective agent is smeared at the round cut, and linen fiber cloth is used for winding around the branch from the base cut to wrap the branch and then is tied tightly; before cutting, three rings of leaves on the upper portion of the branch are left, remaining leaves are sheared away, a bevel cut is sheared from the position 3 cm away from the base towards the base, the branch is sheared to be 16-18 cm long, a rooting promoter is sprayed exactly to the bevel cut, and a cutting branch is obtained for use; the part 8 cm below the base of the cutting branch is inserted in a sand bed matrix until the cutting branch is moved out of a garden for planting. Through the quick cultivation method, the cutting rooting rate is up to 97.2%, and the seedlings can be moved out of the garden within three and a half months to the shortest extent.

The invention relates to a gallbladder wood leaf composition containing strictosamide. The gallbladder wood leaf composition is characterized in that the gallbladder wood leaf composition is prepared by combining alkaloid and flavonoid extracted from gallbladder wood leaf; the alkaloid contains strictosamide,10-hydroxy-strictosamide and short snakeroot glucoside; the flavonoid contains kaempferol-3-O-rutinoside and rutin; and the total weight of the three alkaloid and flavonoid is 50-98% of that of the composition, and the ratio of the total weight of the three alkaloid and the total weight of the flavonoid is (10-0.7):(0.5-10). The invention also discloses a preparation of the composition. The composition provided by the invention can play the role of clearing away heat and toxic materials and relieving swelling and pain, and can treat diseases such as acute tonsillitis, acute pharyngitis, acute conjunctivitis, upper respiratory tract infection or chronic pelvic inflammatory disease and appendagitis; and can cure slight and medium pain.

The invention provides a foam cleaning composition which comprises an anionic surfactant, a nonionic surfactant, tea saponin, sodium alginate, sodium citrate, sodium chloride, a bioenzyme, betaine and the like. The foam cleaning composition can also comprise a bactericidal deodorant, an essence and a colorant. The foam cleaning composition is suitable for cleaning bedpans, and has the characteristics of high foaming speed, fine and abundant foam, long duration time and the like. The bactericidal deodorant is a pure natural antibacterial deodorant, can remove peculiar smell, has favorable bactericidal action, and is harmless to the human body and environment.

The invention relates to an anti-bacterial additive for melamine resins, in particular for melamine-formaldehyde or melamine-urea-formaldehyde resins. Said additive is characterised in that it comprises at least one borate salt and a quaternary ammonium compound as the anti-bacterial active ingredients. As a result of the small number of individual constituents, said additive can be easily incorporated into the melamine resin, is extremely compatible with the latter and has an effective, long-lasting anti-bacterial action.

The invention relates to eardrops, and in particular relates to compound voriconazole eardrops and a preparation method thereof. The compound voriconazole eardrops is characterized in that 0.1-2.0g of voriconazole, 0.1-3.0g of hydrocortisone, 5-40g of hydroxypropyl-beta-cyclodextrin, 10-80ml of polyethylene glycol, 0.1-3.0g of menthol, 0.1-2.0g of sodium chloride, 0.01-0.1g of ethylparaben, 5-60g of glycerin and 10-100ml of ethanol are contained in per 100-1000ml of the eardrops. The compound voriconazole eardrops disclosed by the invention has the beneficial effects that the composing prescription is reasonable and scientific and the voriconazole with the broadest antifungal spectrum is selected as the main medicine, so that the eardrops has antibacterial activity on all candida; the toxic and side effects of systemic administration can be reduced through local application and in the meantime, the eardrops is convenient for application, capable of increasing the curative effect and low in price when being directly used as the eardrops; and the eardrops is stable in quality and little in irritation and adverse reaction.

The invention discloses a citrus fruit fly antibacterial peptide, which is a polypeptide obtained from separation of a citrus fruit fly pupa, with a molecular weight of 2.3 daltons and an isoelectric point of 11.43, and the amino acid sequence of the antibacterial peptide is shown as SEQ ID NO: 1. The invention simultaneously discloses a method for preparing the citrus fruit fly antibacterial peptide, comprising the following steps that: the citrus fruit fly pupa is induced by adoption of a mixed bacteria solution; a crude extract is obtained through tissue homogenate; and the citrus fruit fly antibacterial peptide is obtained after purification through ion exchange chromatography, reversed fast protein liquid phase chromatography and reversed high pressure liquid phase chromatography of the crude extract. The citrus fruit fly antibacterial peptide provided by the invention has inhibition on gram positive bacteria, gram negative bacteria and fungi, has no hemolytic activity, can be taken as a raw material for developing human and poultry biotechnical products with pathogenic microorganism infection resistance, and can be taken as a disease-resistant gene to be used for breeding transgenic plants and transgenic animals by means of gene transformation and other biotechnologies.

The invention discloses a medium for adsorbing stored DNA and a preparation method. The preparation method of the medium for adsorbing the stored DNA is as follows: (1) dissolving a cationic polymer in a water solution of acid the mass concentration of which is 0.1%-10% or in water to prepare a cationic polymer solution; mixing a TE buffer solution and cetyltrimethylammonium bromide (CTAB) to prepare a solution A; and (2) immersing a filter paper in the cationic polymer solution, soaking and taking out, washing by distilled water, putting into the solution A for soaking, and then taking out and drying to obtain the medium for adsorbing the stored DNA. In the invention, a protein denaturing agent is used to ensure the medium to have antibacterial activity, so that the medium can directly extract DNA from the solid medium adsorbing a biological sample or apply a PCR method for amplification, and can be used for medical diagnosis, criminal site sampling, physical evidence preservation, biological sample mailing, epidemiology detection, etc.

The invention provides a novel fluoro-carbostyril derivative which is expressed as the following formula (1) and has antibacterial activity and a preparation method thereof. The preparation method has mild reaction condition, few reaction step, high total yield and convenient postprocessing and can realize the purification of a product just by simple filtering and recrystallization, therefore, the method is suitable for industrialized production.

The invention belongs to the field of molecular biology and microbial fermentation, and provides a Surfactin and Plipastatin co-production bacillus subtilis strain pB2-L, a method for constructing the same and application of the Surfactin and Plipastatin co-production bacillus subtilis strain. The method for constructing the Surfactin and Plipastatin co-production bacillus subtilis strain includes steps of amplifying target genes; amplifying fusion fragments; acquiring intermediate vectors; acquiring recombinant integration plasmids; acquiring and detecting transformants. The Surfactin and Plipastatin co-production bacillus subtilis strain, the method and the application have the advantages that a fragment of fusion genes P43-sfp-degQ are led into amyE site of B-subtilis pB2 of non-producing antibacterial substances Surfactin and Plipastatin by the aid of homologous recombination processes, so that the recombinant Surfactin and Plipastatin co-production bacillus subtilis strain B.subtilis pB2-L can be obtained, the strain has certain antibacterial activity for gram positive bacteria and filamentous fungi, and the Surfactin and Plipastatin co-production bacillus subtilis strain, the method and the application have an important significance on follow-up study.

The invention relates to an antibacterial peptide gene and a preparation method thereof; the antibacterial peptide gene provided by the invention is ascaris suum antibacterial peptide Cecropin P2; and coded ascaris suum antibacterial peptide Cecropin P2 is firstly separated from mammals in vivo. The antibacterial peptide gene provided by the invention is a gene Cecropin P2' obtained by optimizing the ascaris suum antibacterial peptide Cecropin P2; a sequence of the antibacterial peptide gene is SEWNo1; in the sequence, a sixth codon is changed from original ctc into ctg in an optimization method; a ninth codon, a twelfth codon and an eighteenth codon are changed from original aaa into aag in an optimization method; by dint of above-mentioned optimization, a target gene can be expressed preferably in a pichia pastoris system.

The invention relates to synthesis and an application of a series of cetyl or octadecyl dimethyl tertiary amine quaternary ammonium salt high performance fluorescent whitening agents having an amino acid structure, wherein the whitening agents are mainly used in papermaking, coating, printing ink and weaving. The synthesis comprises the following steps: a, reacting cyanuric chloride with N,N-dimethyl cetyl (or octadecyl) tertiary amine for 2.5h at 0-5 DEG C, controlling the pH value to 3-4, and synthesizing to obtain an one-step condensation product; b, reacting the one-step condensation product with DSD acid at 45 DEG C for 4h, controlling the pH value to 6-7, and synthesizing to obtain a two-step condensation product; and c, reacting the two-step condensation product with amino compounds at 90-95 DEG C for 6h, controlling the pH value to 8-9, and synthesizing to obtain the cetyl or octadecyl dimethyl tertiary amine quaternary ammonium salt high performance fluorescent whitening agents having the amino acid structure.

A preparation method of acyclovir-chitosan nanoparticles comprises the following steps: dissolving acyclovir in chitosan acetum, dropping aqueous solution of sodium tripolyphosphate as a crosslinking agent, obtaining drug-loading chitosan nanoparticles after centrifuging and freeze drying, dropping the chitosan nanoparticles in aqueous solution of gelation, and obtaining chitosan-gelation nanoparticles containing acyclovir after centrifuging and freezing drying. The preparation method has the advantage of improving the delayed release effect of medicine by embedding medicine in particles in embedding manner; and the preparation method has simple preparation technology and low cost, and is easy for large-scale production.