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Effervescent cefdinir prepn and its prepn process

A technology for cefdinir and effervescent preparations, applied in the field of cefdinir effervescent preparations and their preparation, can solve problems such as cefdinir effervescent preparations that have not yet been seen, and achieve novel effervescent sensory perception, low bioavailability, slow onset effect

Inactive Publication Date: 2005-12-14
JINAN PINGZHI MEDICINE SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no cefdinir effervescent preparations and related reports at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] [group ratio]

[0035] Cefdinir 5.0g

[0036] Lactose 4.2g

[0037] Sucrose 0.6g

[0038] Aspartame 1.7g

[0039] Vanillin 2.6g

[0040] Sodium bicarbonate 5.3g

[0041] Citric acid 4.0g

[0042] Absolute ethanol about 1ml

[0043] Polyethylene glycol 1.6g

[0044] Makes 100 pieces

[0045] [Preparation]

[0046] (1) Cefdinir, lactose, sucrose, aspartame, vanillin, sodium bicarbonate and citric acid are mixed and pulverized through a 100-mesh sieve, and mixed uniformly;

[0047] (2) Add about 1ml of absolute ethanol into the mixed powder to make a soft material, and granulate with an 18-mesh sieve;

[0048] (3) drying the wet granules at 40°C;

[0049] (4) The dried particles pass through a 18-mesh sieve for granulation, add a proportioning amount of polyethylene glycol, and mix;

[0050] (5) Compress the prepared granules into tablets to obtain the required cefdinir effervescent tablet.

...

Embodiment 2

[0055] [group ratio]

[0056] Cefdinir 10.0g

[0057] Lactose 8.0g

[0058] Povidone K30 1.6g

[0059] Aspartame 3.4g

[0060] Vanillin 5.2g

[0061] Sodium bicarbonate 10.6g

[0062] Tartaric acid 8.0g

[0063] Absolute ethanol about 2ml

[0064] Polyethylene glycol 3.2g

[0065] Makes 100 bags

[0066] [Preparation]

[0067](1) Cefdinir, lactose, povidone K30, aspartame, vanillin, sodium bicarbonate and tartaric acid are mixed and pulverized through a 100 mesh sieve, and mixed uniformly;

[0068] (2) Add about 2ml of absolute ethanol into the mixed powder to make a soft material, and granulate with a 10-mesh sieve;

[0069] (3) Dry the wet granules at 40°C;

[0070] (4) sieving the dried particles through a 10-80 mesh sieve, adding a proportioning amount of polyethylene glycol, and mixing;

[0071] (5) Subpackage the prepared granules to obtain the required cefdinir effervescent granules.

[0072] The above operations need...

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PUM

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Abstract

The present invention relates to cefdinir as one kind of cephalosporin, and is especially effervescent cefdinir preparation and its preparation process. The present invention features that the effervescent cefdinir preparation consists of cefdinir 15-25 wt%; disintegrating agent including acid 13-23 wt% and alkali 25-35 wt%; and other components including stuffing 14-24 wt%, adhesive 1-5 wt%, moistener 1-5 wt%, lubricant 5-9 wt%, sweetener 6-10 wt% and aromatic 8-16 wt%. The effervescent cefdinir preparation has the advantages of easy taking, fast absorption in body, good taste, etc.

Description

(1) Technical field [0001] The invention relates to cephalosporin antibiotic cefdinir, in particular to an effervescent cefdinir preparation and a preparation method thereof. (2) Background technology [0002] Cefdinir (Cefdinir, FK482, CFDN) is an oral cephalosporin antibiotic developed by Fujisawa Pharmaceutical Co., Ltd. of Japan to overcome the weak antibacterial effect of cefixime (Cefixime, CFZX) on Staphylococcus aureus. Bacteria and negative bacteria all showed broad-spectrum antibacterial effect, especially showed good antibacterial effect on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus and Pneumococcus. Cefdinir is stable to β-lactamase and is often widely used in clinical, surgical and gynecological infections. [0003] At present, cefdinir capsules and cefdinir granules have been produced and used clinically at home and abroad, but cefdinir capsules and cefdinir granules have the disadvantages of slow onset of action and low bioavailabilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546
Inventor 张汝德赵立丽
Owner JINAN PINGZHI MEDICINE SCI TECH
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