204 results about "Effervescent granules" patented technology

According to the present invent, effervescent granules having a controllable rate of effervescence are provided. Such granules comprise an acidic agent, an alkaline agent, a hot-melt extrudable binder capable of forming a eutectic mixture with the acidic agent and, optionally, a plasticizer. The effervescent granules are made by a hot-melt extrusion process.

Disclosed here are effervescent granules having a controllable rate of effervescence. In some embodiments, the such granules comprise an acidic agent, an alkaline agent, a pharmacologically active agent, hot-melt extrudable binder capable of forming a eutectic mixture with the acidic agent and, optionally, a plasticizer. The effervescent granules are made by a hot-melt extrusion process. The present invention also provides a thermal heat process for preparing a pharmacologically active agent containing effervescent granule. In certain aspects, the granules contain pharmacologically active agents such as narcotics, antidiarrheal agents, antiviral agents, anxiolytic agents, a cholesterol lowering agent, an alpha adrenergic blocking agent, a phenanthrene derivative. By way of example, some of the narcotics that may be included in the granules and in the process of preparing the granules include, by way of example: phenanthrene derivatives (e.g., morphine sulfate), and morphine derivatives (e.g., hydromorphone hydrochloride).

The invention relates to medical composition containing metformin and Vildagliptin and a preparation method thereof. The medical composition is formed by taking metformin chloride and Vildagliptin as medical active components and blending with pharmaceutically acceptable auxiliary materials; the invention adopts the metformin chloride and Vildagliptin as materials and adds auxiliary materials with some special kinds and proportions to prepare and develop diversified oral preparations such as tablets, capsules, granules, dispersible tablets, chewable tablets, buccal tablets, effervescent tablets, effervescent granules according to the technical method of the invention. The medical composition of the invention can be used for treating diabetes type II that can not be properly cured by alimentary control and sports and also for diabetes type II that can not be controlled by simply using metformin chloride or Vildagliptin.

The invention belongs to agricultural effervescent granules, and relates to the effervescent granules containing surfactants and a preparation method and application thereof. The agricultural effervescent granules are mainly mixed with pesticide preparations or fertilizers for use, do not comprise active ingredients of a pesticide and are used as an auxiliary agent of the pesticide preparations or fertilizers. The agricultural effervescent granules comprise an acid source, a carbonate source and 40 to 90 weight percent of surfactants, wherein the weight percentage of the surfactant is more than 40. One preferred scheme of the invention is that: one of the surfactants is an organosilicon surfactant. The preparation method of the invention comprises the steps of weighing, mixing, crushing, granulating and drying the ingredients. The application of the effervescent granules of the invention is that: the effervescent granules are mixed with the pesticide preparations or the fertilizers for use; and the proportion of the effervescent granules to the pesticide preparations or the fertilizers is 1-1,999:1,999-1. The agricultural water dispersible granules of the invention are mixed with the pesticide preparations or fertilizers in use, so the functions of diluting, reducing the content of the active ingredients, improving the suspensibility of the active ingredients, accelerating dissolution, dispersing, wetting, permeating, thickening, defoaming, filming and adhering and the like are realized, the ratio of absorbing and utilizing the active ingredients by crops is improved, and the pesticide and fertilizer pollution on environment is reduced.

This invention provides an effervescent solid form that dissolves in cold water quickly enough to not disappoint consumers yet not so quickly that the visual interest generated during the effervescent reaction is lost. This performance is achieved by forming effervescent particles that are dense enough to retard dissolution and small enough to not take too long to dissolve. The aim of this invention is to provide a beverage in solid effervescent form that takes between about 30 and about 120 seconds to dissolve in warm water. The granules may carry functional additives such as flavors, vitamins, minerals, sweeteners, colors and drugs. The granules may also be compounded of materials intended to provide relief from skin or topical discomfort, as in the form of a wash or bath additive. The granules may also be formulated to provide cleaning agents, such as ceramic cleaners and denture cleaners.

The invention discloses a preparation method of effervescent tablets. Polyethylene glycol is heated and melted and then is diluted with ethanol, a polyethylene glycol-ethanol solution is formed and then coats an acid source and an alkaline source, and accordingly, acid-source granules coated with polyethylene glycol film layers and alkaline-source granules coated with polyethylene glycol film layers are formed; the acid-source granules and the alkaline-source granules are sufficiently mixed and stirred, a mixture is formed, an ethanol solution of polyvinylpyrrolidone K30 is added to the mixture for secondary coating, a product is crushed after being dried, and effervescent granules coated with double organic film layers are obtained after uniform mixing; main medicine ingredients of a medicine and other acceptable excipients used for preparation of the effervescent tablets are added to the effervescent granules, and the effervescent tablet preparations are obtained through tableting after sufficient mixing. The prepared effervescent tablets are not prone to moisture absorption and deterioration and have good flowability; the forming rate is high, and sticking is avoided; the disintegration is fast. According to the method, adopted raw materials are cheap and easy to obtain, the method is simple, pollution-free and harmless to a human body, has low requirements for equipment and has good application prospect, and industrial production is easily realized.

The invention discloses sucralose effervescent granules. The sucralose effervescent granules are characterized by being prepared by taking sucralose as a main sweetener, taking acid auxiliary excipients, such as organic acids, alkaline excipients, such as sodium bicarbonate and the like as effervescing agents and performing the processes of scientific composition, respective granulation, low-temperature drying and the like; the sweetener has the advantages of stable nature, convenience in use, realistic taste, no sugar, health care and the like; a new way for applying the sucralose is opened up, the sucralose effervescent granules are of a new formulation of the sucralose, and the application prospect is broad; and the invention further provides a preparation method of the sucralose effervescent granules.

The invention provides a calcium carbonate effervescent granule. The weight ratio of the calcium carbonate effervescent granule is 1: 0.3 - 0.7: 1 - 2:0.3 - 0.5 of calcium carbonate, vitamin D, acidic foaming agent and sodium bicarbonate. The invention also provides a method for preparing the calcium carbonate effervescent granule; the calcium carbonate effervescent granule is used for supplying calcareous to human body or preventing and treating osteoporosis and children rickets.

The invention relates to an enzyme compound having a bowel relaxing effect. The enzyme compound is prepared from, by weight, 1-15 parts of probiotics, 10-120 parts of plant enzyme stock solution and 10-80 parts of traditional Chinese medicine extract, the enzyme compound is prepared by conducting a sterilization process on the traditional Chinese medicine extract, then mixing the extract with the plant enzyme stock solution and inoculating the probiotic florae for airtight fermentation. The traditional Chinese medicine extract is prepared from, by weight, 2-10 parts of sea-buckthorn, 2-10 parts of dahurian rose fruits, 1-8 parts of yam, 2-10 parts of lithospermum erythrorhizon, 2-8 parts of scorched hawthorn fruits, 1-8 parts of tangerine seeds, 0.5-6 parts of grapefruit flowers, 0.5-6 parts of silene aprica, 0.5-6 parts of jujubes and 0.5-5 parts of dried tangerine or orange peels. The enzyme compound enables the probiotics and functional oligosaccharides to be used in a combined mode, the traditional Chinese medicine ingredient is added, the bowel relaxing effect is achieved, and the enzyme compound is suitable for populations who cannot perform blood circulation and hematogenesis due to qi deficiency and accordingly suffer from intestinal moisture loss and constipation.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a plant growth regulator-1-methyl propylene effervescent granule / or effervescent tablet and a preparation method thereof. The 1-methyl propylene effervescent granule / or effervescent tablet is prepared from the following raw materials in percentage by mass: 0.01%-20% of 1-methylcyclopropene, 0.5%-15% of a dispersing agent, 0.5%-8% of a wetting agent, 4%-60% of a disintegrating agent, 0-10% of a binder and a filler; and the preparation method comprises the following steps: mixing various raw materials for forming the 1-methyl propylene effervescent granule / or effervescent tablet; and carrying out superfine / airflow smashing, pelletizing, drying, arranging / tabletting, selecting and detecting, so as to obtain the plant growth regulator-1-methyl propylene effervescent granule / or effervescent tablet. The 1-methyl propylene effervescent granule / or effervescent tablet provided by the invention is safe to environment, people, livestock and other beneficial organisms and accurate to meter; a pesticide hazard is not easy to generate; compared with an ordinary encapsulated granule, the 1-methyl propylene effervescent granule / or effervescent tablet is free of dust, high in granular disintegration speed, convenient to use, good in storage stability, and simple in preparation technology and is suitable for industrialized production and large-area popularization and application in the field of preservation of fruits, vegetables and flowers; and effective components can be fully released within the stipulated time during use.

The invention discloses a solid wine, in particular to a solid effervescent wine, which is characterized in that: the solid wine adopts solid wine powder as raw material, and then auxiliary materials of antacids, alkaline agent, filler, adhesive, lubricant, sweetener, correction, toning agent, and stabilizer, etc. are added, to produce effervescent granules or effervescent tablets. When being put into the water, the solid effervescent wine disintegrates without any stirring, produces a great number of bubbles. Moving like the effervescent, the solid wine has the advantages of convenient storage, delivery and carrying, and no preservatives. The users can adjust the concentration of the wine in accordance with the needs. In addition, the solid wine is more suitable for travelling and for the elders and women who can not drink a lot.

The invention relates to a pharmaceutical composition which takes metformin hydrochloride and vildagliptin as the active ingredients and the preparation method and usage thereof. The invention takes metformin hydrochloride and vildagliptin as the pharmaceutical active ingredients and mixed with pharmaceutically acceptable excipients to form the pharmaceutical composition. The invention can be used for diet control and the treatment of type 2 diabetes can not be controlled appropriately by movements, and the invention can also be used in the type 2 diabetes which can not be controlled by the single administration of metformin hydrochloride or vildagliptin. The contents of the invention take metformin hydrochloride and vildagliptin as the raw materials and are added with given type and proportion of excipients, then the invention is prepared and developed into tablets, capsules, granules, dispersion tablets, chew tablets, buccal tablets, effervescent tablets, effervescent granules and other various oral preparations according to the technical means illustrated by the invention.

A particulate laundry detergent composition having an equilibrium relative humidity value at 25° C. and 1 atmosphere of at least 10% and comprising an effervescent granule, the effervescent granule comprising an acid source, a carbonate source and a desiccant is provided. The granules are stable even though they are contained within a humid environment.

The invention relates to ivermectin effervescent granules for poultries. The ivermectin effervescent granules for poultries disclosed by the invention are composed of the following raw materials in parts by weight: 30-90 parts of ivermectin, 50-80 parts of citric acid, 60-90 parts of sodium bicarbonate, 30-60 parts of polyethylene glycol 6000, 60-90 parts of dextrin, and 80-200 parts of glucose. The ivermectin effervescent granules for poultries disclosed by the invention are prepared by crushing the above raw materials, mixing, granulating, drying and straightening. Different from common granules, the ivermectin effervescent granules for poultries disclosed by the invention contain an effervescent disintegrant; when the effervescent granules are put into drinking water, a large number of bubbles can be generated instantly under the action of the effervescent disintegrant, so that the granules are disintegrated and molten rapidly; therefore, taste buds of animals are stimulated; the release and action time of medicines are increased; furthermore, reagents adopted are conventional medicines, and thus, the ivermectin effervescent granules for poultries disclosed by the invention are low in preparation cost and easy to popularize and apply.

The invention relates to a brevibacillus brevis TW effervescent granule. The brevibacillus brevis TW effervescent granule is prepared through the following steps of: mixing a brevibacillus brevis TW strain single colony plaque PDA (Potato Dextrose Agar) liquid culture solution with soybean meal, corn meal, starches, cane sugar, yeast powder, calcium carbonate and MnSO4 by adding water; mixing bacterial fermentation liquor obtained by fermenting under the conditions of 100% dissolved oxygen, the pH of 7.0-7.2 and the temperature of 30 DEG C with the cane sugar, polyvinyl alcohol, citric acid monohydrate, potassium tartrate and sodium bicarbonate according to a proportion; screening, granulating, and drying through steam flows at a temperature of 60 DEG C, wherein the total concentration ofviable bacteria of a finished product is about 1*10<9>-1*10<10> cfu / g. The brevibacillus brevis TW effervescent granule can be effectively suspended on a water surface and then fast disintegrated, releases the biocontrol bacteria of living bodies and enables the biocontrol bacteria to attach to the contact surface of the stem of a rice plant and the water surface, thereby effectively cutting off or spatially occupying the initial invasion of rice rhizoctonia solani on the rice stem and achieving the purpose that control effect on rice sheath blight reaches more than 80 percent; and the brevibacillus brevis TW effervescent granule is convenient for application, has low cost and can be preserved for 2-3 years at normal temperature.

The invention discloses a vitamin C effervescent granule and a preparation method thereof applied to the field of preparations of vitamin C. The vitamin C effervescent granule comprises acid granules and alkali granules; the acid granules mainly comprise vitamin C and effervescent agent acid sources; the alkali granules mainly comprise effervescent agent alkali sources; the effervescent agent acid sources are effervescent agent acid sources crystals; or the effervescent agent acid sources are the effervescent agent acid source crystals and the vitamin C which is a vitamin C crystal. The preparation method comprises the steps of respectively preparing the acid granules and the alkali granules; and packaging the acid granules and the alkali granules according to the proportion of a prescription to obtain the VC effervescent granule. According to the vitamin C effervescent granule and the preparation method thereof disclosed by the invention, the acid granules are prepared from the effervescent agent acid source crystals and the vitamin C crystal, so that the disintegration speed of the vitamin C effervescent granule is improved and the effervescent granule can be quickly disintegrated at a lower water temperature; and meanwhile, the stability of the vitamin C effervescent granule is improved by adopting accessories with small hygroscopicity, and thus the storage and the transportation of the vitamin C are facilitated.

The invention relates to a plant growth regulator, which is characterized in that the content of an effective active ingredient brassinolide is 0.01 to 5%, and the brassinolide is added with appropriate amount of additives and excipients to be made into water dispersible granules, effervescent granules and effervescent tablets. The composition of the invention can promote the development of roots, enhance photosynthesis, improve the chlorophyll content of crops, promote the effective absorption of crops for fertilizers, and help the inferior parts of the crops grow well, increase yield and improve quality. The invention has the advantage of low toxicity, basically no pollution on the environment, safe use, high efficiency, strong penetration, good systemic performance, convenient storage and the like.

The invention relates to a Qiqing Baidu effervescent granule, belonging to the pharmaceutical field of traditional Chinese medicines. The Qiqing Baidu effervescent granule is prepared from the following raw materials and auxiliary materials in part by weight: raw materials: 100 parts of baical skullcap root, 100 parts of giant knotweed rhizome, 80 parts of pulsatilla chinensis, 80 parts of lightyellow sophora root, 100 parts of isatis root, 60 parts of male fern rhizome and 40 parts of indigowoad leaves; and auxiliary materials: 72-88 parts of sodium bicarbonate, 60-74 parts of fumaric acid, 387-417 parts of thinning agents and 11-15 parts of flavoring agents. The effervescent granule is prepared by utilizing a method for separately granulating with acid-alkali. In the invention, the Qiqing Baidu effervescent granule is prepared by taking the sodium bicarbonate as an alkaline agent and fumaric acid as an acidic agent and adding other auxiliary materials; the use level of the auxiliary materials can be reduced; and the effervescent granule has the advantages of simple preparation process, high effervescent speed, favorable effervescent effect, dissolubility and liquid medicine clarity after being effervesced, is easily formed and does not absorb moisture easily.

The invention discloses a traditional Chinese medicine composition for treating respiratory tract viral infectious diseases and a preparation method thereof. The composition comprises the following active pharmaceutical ingredients in parts by weight: 5-25g of perilla leaf, 5-25g of tatarian aster root, 5-25g of Chinese thorowax root, 5-25g of schizonepeta spike, 5-25g of great burdock achene, 5-25g of apricot seed and 1-15g of liquoric root. The active pharmaceutical ingredients can be matched with excipients and a flavoring agent to be directly or indirectly prepared into pharmaceutically acceptable capsules, oral liquid, granules, syrup, tablets, effervescent particles, dropping pills, aerosol, spraying agent, gargle, mouthwash and a variety of formulations via conventional process steps. The traditional Chinese medicine composition can be clinically used for treating or preventing the respiratory tract viral infectious diseases caused by influenza A virus, influenza B virus, rhino virus, coronavirus, respiratory syncytial virus, adenovirus, parainfluenza virus, enteric cytopathogenichuman orphan virus, Coxsackie virus and the like.

The invention discloses a method for preparing effervescent granules of Chinese date by using a dry granulation technology. The method comprises the following steps of: 1) decocting the Chinese date by adding water, filtering the decoction, concentrating the filtrate in vacuum under reduced pressure to obtain clear paste, adding dextrin, stirring the dextrin and the clear paste uniformly, and then performing spray drying to obtain dry extract powder; and 2) adding a certain amount of screened anhydrous citric acid, sodium hydrogen carbonate and lauryl sodium sulfate into the dry extract powder, mixing, putting the mixture into a dry granulator to prepare granules, and then packing the granules to obtain the effervescent granules. The production cost is reduced; and the prepared effervescent granules have high dissolution speed and uniform dispersion, are convenient to carry, transport and store, do not contain preservative or sugar, are nutritional and healthy, and can be convenient for diabetics to administrate.

The invention relates to dispensing process for natural ribes burejense effervescent granule and buccal-tablet, which includes selecting ribes burejense fruit, cleaning, drying moisture on the surface, juice extracting according to the prescription; standing for 24 hours, filtering the standed solution, sterilizing by an ozone or ultraviolet lamp; pressure reduced concentrating the original juice of ribes burejense into fluid extract; grinding sucrose into powder, mixing with the ribes burejense fluid extract and the isomalt compound sugar (900) and stirring uniformly. Then the granule product is obtained by making the mix into acid, alkali granules, mixing the acid, alkali granules and packing according to a predetermined weight ratio; the tablet product is obtained by stirring the material uniformly, pressing into tablet according to the predetermined weight without exceeding the error rate of 10% positively or negatively, sampling checking by a quality check department, packing after getting through the check.

The invention discloses gibberellin effervescent granules or tablets and a preparation method thereof. The gibberellin effervescent granules or tablets are prepared from the following raw materials in percentage by mass: 0.01 to 50 percent of gibberellin, 0.5 to 15 percent of dispersing agent, 0.5 to 8 percent of wetting agent, 4 to 60 percent of disintegrating agent, 0 to 10 percent of adhesive and the balance of filler. The preparation method comprises the following steps of: mixing the raw materials for preparing the gibberellin effervescent granules or tablets, performing ultramicro airflow crushing, granulating, drying, finishing grains or tableting, selecting, and detecting to obtain the gibberellin effervescent granules or tablets. The gibberellin effervescent granules or tablets are safe for environment, human, animals and other beneficial organisms, hardly generate phytotoxicity, and are accurate in metering, convenient to use, high in disintegration speed, high in storage stability, simple in preparation process and suitable for industrial production and agricultural large-area promotion and application.

The invention discloses an effervescent granule containing chlorantraniliprole and emamectin benzoate. The effervescent granule is mainly applied to control of insect pests on crops. The composition comprises the effective components of 1-20% of chlorantraniliprole, 1-20% of emamectin benzoate, 2-10% of dispersing agent, 1-5% of wetting agent and 1-5% of stabilizer, and also comprises 0.5-20% of disintegrating agent, 5-20% of acid source, 5-20% of carbon dioxide gas source, 0.01-2% of binder and the balance of inert filler. The invention simultaneously discloses a preparation method of the effervescent granule. The method comprises the following steps: firstly, crushing raw materials into particles with the particle size of less than 10 microns by a jet mill, and mixing by a mixer; and simultaneously adding binder slurry, evenly mixing, and then drying and screening to prepare the effervescent granule by an effervescent pelletizer. The effervescent granule is free of pollution on environment, fast to disintegrate, accurate to meter and convenient to use. The insecticidal compound effervescent granule belongs to an environment-friendly pesticide, and is free of three wastes in production and convenient to use.

The invention discloses a medicine composition for treating the infectious bursal diseases of chickens and a preparation method thereof. The medicine composition for treating the infectious bursal diseases of the chickens is prepared by the following traditional Chinese medicines according to a certain proportion in parts by weight: 40 to 80 parts of dandelion, 60 to 100 parts of isatis leaf, 160 to 240 parts of radix isatidis, 40 to 80 parts of honeysuckle, 20 to 60 parts of baikal skullcap root, 20 to 60 parts of yellow-corktree bark, 20 to 60 parts of wrinkled giant hyssop, 60 to 120 parts of gypsum, 40 to 80 parts of licorice, 25 to 40 parts of organic acid, 40 to 60 parts of weak base, 3 to 6 parts of lubricant and 5 to 10 parts of sweetening agent. The preparation formulation of the composition is effervescent granules. The preparation method comprises the following steps of: pulverizing the bulk drugs, adding water, decocting, carrying out alcohol precipitation on filtrate, concentrating after recovering ethanol from supernatant liquid, and drying so as to obtain an extract; and dividing the extract into two equal parts, adding the organic acid, the lubricant and the sweetening agent into one part so as to prepare acid granules, drying for standby application, adding the weak base, the lubricant and the sweetening agent into the other part so as to prepare alkali granules, drying for standby application, then mixing the two kinds of granules evenly, granulating and packaging so as to obtain the medicine composition for treating the infectious bursal diseases of the chickens. Various medicines in the medicine composition for treating the infectious bursal diseases of the chickens are combined for use. The medicine composition for treating the infectious bursal diseases of the chickens has the effects of invigorating qi, strengthening the spleen, nourishing yin, clearing heat, cooling blood, removing toxic materials and the like. The effect of treating the infectious bursal diseases of the chickens by utilizing the medicine composition for treating the infectious bursal diseases of the chickens is obvious; and moreover, the cost is low, and the toxic or side effect is small.

The invention relates to a composition mainly containing lactase and vitamin D. The composition is mainly used for improving lactose intolerance and promoting calcium absorption. The composition is mixed with proper adjuvants, and then preapred into a plurality of oral products such as conventional tablet, effervesce, buccal tablets, milk tablet, orally disintegrating tablet, granule, effervescent granule, powder, capsule and soft capsule.