Cefdinir dispersible tablet and preparation method thereof

Abstract

The invention relates to a preparation method of a medicinal preparation taking cefdinir as a main ingredient, and in particular relates to the preparation method of a cefdinir dispersible tablet. The method comprises the following steps: taking the cefdinir in a therapeutic dose as a main raw material; micronizing the cefdinir to form the powder with the particle diameter of 60 to 150 mu m; adding assistant medicinal materials in proper quantity into the cefdinir to be directly pelletized by using a dry method; and directly pressing a pellet into the tablet, wherein the assistant medicinal materials comprise micronized milk sugar or starch, microcrystalline cellulose, aspartame and cross-linking povidone. The cefdinir dispersible tablet comprises the following ingredients in parts by weight: 100 parts of the cefdinir, 30 to 100 parts of the starch, 80 to 200 parts of the microcrystalline cellulose, 5 to 15 parts of the aspartame, 8 to 20 parts of the cross-linking povidone and 20 to 50 parts of magnesium stearate. The method provided by the invention has the advantages that the operation is simple; and the prepared cefdinir dispersible tablet is stable in quality, rapid in dissolution rate and high in bioavailability.

Description

technical field [0001] The invention relates to a pharmaceutical preparation with cefdinir as the main component and a preparation method thereof in the technical field of pharmaceutical preparations, in particular to a cefdinir dispersible tablet and a preparation method thereof. Background technique [0002] Cefdinir (cefdinir), chemical name: (6R, 7R)-7-[[(2-amino-4-thiazolyl)-(oximino)acetyl]amino]-3-vinyl-8-oxo -5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, molecular formula: C 14 h 13 N 5 o 5 S 2 , molecular weight: 395.42, its structural formula is as follows: [0003] [0004] Cefdinir is a third-generation cephalosporin antibacterial drug, its mechanism of action is to prevent the synthesis of bacterial cell walls, and its action characteristics vary with bacterial species. strong affinity. It has a wide range of antibacterial spectrum against Gram-positive bacteria and Gram-negative bacteria, especially Staphylococcus aureus and Streptococcus amo...

AI Technical Summary

Problems solved by technology

[0007] The dissolution rate of a drug is a key factor limiting its absorption and bioavailability. In recent years, although some technical methods such as solubilization, co-dissolution, cyclodextrin encapsulation and solid dispersion technology have emerged to improve the drug dissolution rate, the These techniques have limitations

And it has the disadvantages of environmental pollution, low drug loading and large dosage, so the emergence of micronization technology provides an effective way to solve this problem

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