The invention provides enramycin dry suspension which contains 2 percent to 8 percent of enramycin, 20 percent to 60 percent of filler, 10 percent to 40 percent of flavoring, 5 percent to 30 percent of suspending aid and 1 percent to 10 percent of wetting agent. In addition, the invention provides a preparation method of the enramycin dry suspension. Compared with premix, when being used temporarily, the enramycin dry suspension can be dispersed into supensoid agent for oral taking only by being added with water and shaken; when being used, the enramycin dry suspension can become solution only by being added with water, the dispersion is uniform, and the defects when the premix is used are overcome; meanwhile, the specific surface area of the enramycin dry suspension is larger than that of the premix, the absorption is quick, the bioavailability is high and the cure rate is higher. Compared with the solution, the enramycin dry suspension is always in a dry state without water, so that the stability is more easily realized. In addition, the enramycin dry suspension is conveniently used, so that a lot of manpower and materials are saved. But a technology of preparing dry suspension with the enramycin is not yet reported.