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Enramycin dry suspension and preparation method thereof

A technology of enramycin and dry suspension, applied in the field of enramycin dry suspension and preparation thereof, can solve problems such as uneven mixing, poisoning, unsatisfactory drug effect, etc. Convenient, fast-acting effect

Inactive Publication Date: 2013-03-06
GUANGDONG RONGDA BIOENG CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the enramycin premix has the following disadvantages: when the premix is ​​mixed in use, the drug effect is not ideal due to uneven mixing, or the feed intake of poultry falls after the onset of the disease, and the phenomenon of poisoning caused by taking feed with high local drug concentration

Method used

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  • Enramycin dry suspension and preparation method thereof
  • Enramycin dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Enramycin 2g

[0038] Sucrose 60g

[0039] Sodium saccharin 10g

[0040] Methylcellulose 25g

[0041] Glycerin 3g

[0042] The preparation method is as follows:

[0043] (1) Accurately weigh the enramycin of the prescribed amount and pass through an 80-mesh sieve;

[0044] (2) Accurately weigh the sucrose, sodium saccharin, and methylcellulose of the prescribed amount respectively, pass through an 80-mesh sieve respectively, and mix uniformly in equal increments;

[0045] (3) Steps (1) and (2) are mixed in equal increments to obtain a mixed powder;

[0046] (4) Add 3g of glycerin to the mixed powder to make a soft material, and pass through a 40-mesh sieve;

[0047] (5) Dry at 60°C, granulate with 40 mesh sieve;

[0048] (6) After the intermediate is qualified, the finished product can be obtained by sub-packaging.

Embodiment 2

[0050] Enramycin 8g

[0051] Mannose 20g

[0052] Cyclamate 40g

[0053] Hydroxypropyl Methyl Cellulose 30g

[0054] 50% ethanol 2g

[0055] The preparation method is as follows:

[0056] (1) Accurately weigh the enramycin of prescription quantity and pass through 120 mesh sieves;

[0057] (2) Accurately weigh the mannose, cyclamate, and hydroxypropyl methylcellulose of the prescribed amount respectively, pass through a 120-mesh sieve respectively, and mix them uniformly in equal increments;

[0058] (3) Steps (1) and (2) are mixed in equal increments to obtain a mixed powder;

[0059] (4) Add 2 g of 50% ethanol to the mixed powder to make a soft material, and pass through a 30-mesh sieve;

[0060] (5) Dry at 80°C, granulate with a 30-mesh sieve;

[0061] (6) After the intermediate is qualified, the finished product can be obtained by sub-packaging.

Embodiment 3

[0063] Enramycin 4g

[0064] Sorbitol 65g

[0065] Ansai K 25g

[0066] Polyvinylpyrrolidone 5g

[0067] Propylene glycol 1g

[0068] The preparation method is as follows:

[0069] (1) Accurately weigh the prescribed amount of enramycin and pass through a 100-mesh sieve;

[0070] (2) Accurately weigh the sorbitol, sulfame potassium acetate, and polyvinylpyrrolidone of the prescribed amount respectively, pass through a 100-mesh sieve respectively, and mix uniformly in equal increments;

[0071] (3) Steps (1) and (2) are mixed in equal increments to obtain a mixed powder;

[0072] (4) Add propylene glycol to the mixed powder to make a soft material, and pass through a 35-mesh sieve;

[0073] (5) Dry at 70°C, granulate with 35 mesh sieve;

[0074] (6) After the intermediate is qualified, the finished product can be obtained by sub-packaging.

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Abstract

The invention provides enramycin dry suspension which contains 2 percent to 8 percent of enramycin, 20 percent to 60 percent of filler, 10 percent to 40 percent of flavoring, 5 percent to 30 percent of suspending aid and 1 percent to 10 percent of wetting agent. In addition, the invention provides a preparation method of the enramycin dry suspension. Compared with premix, when being used temporarily, the enramycin dry suspension can be dispersed into supensoid agent for oral taking only by being added with water and shaken; when being used, the enramycin dry suspension can become solution only by being added with water, the dispersion is uniform, and the defects when the premix is used are overcome; meanwhile, the specific surface area of the enramycin dry suspension is larger than that of the premix, the absorption is quick, the bioavailability is high and the cure rate is higher. Compared with the solution, the enramycin dry suspension is always in a dry state without water, so that the stability is more easily realized. In addition, the enramycin dry suspension is conveniently used, so that a lot of manpower and materials are saved. But a technology of preparing dry suspension with the enramycin is not yet reported.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a dry suspension of enramycin and a preparation method thereof. Background technique [0002] Enramycin, also known as Enramycin, Enramycin, and Duramycin, is a broad-spectrum, high-efficiency, and safe new feed additive. It is a polypeptide antibiotic fermented by actinomycetes , is enramycin A (C 107 h 138 C l2 N 26 o 31 ) and enramycin B (C 108 h 140 C l2 N 26 o 31 ), the hydrochloride of the medicine is white or yellowish white powder (with special odor), easily soluble in dilute hydrochloric acid, slightly soluble in water, methanol, ethanol, insoluble in acetone. The drug was first developed by Takeda Pharmaceutical Co., Ltd. in Japan in the 1960s. In 1973, Japan officially approved the drug as an antibiotic feed additive and has been used until now. In 1993, Takeda Pharmaceutical Co., Ltd. of Japan applied to the Ministry of Agriculture ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K38/12A61P31/04
Inventor 杨亚勇蒋顺进刘元江陈景勇曾玉勤方文棋黄炜乾刘宗新陈益钦
Owner GUANGDONG RONGDA BIOENG CO LTD
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