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Glutathione enteric-coated pellet and preparation method thereof

A technology of glutathione and enteric-coated pellets, which is applied in the directions of tripeptide components, pharmaceutical formulations, and inactive medical preparations, etc., can solve problems such as poor drug compliance, achieve uniform size and ensure stability , the effect of large distribution area

Inactive Publication Date: 2009-12-16
KUNMING JIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the small space of the oral cavity, taking multiple tablets and taking medicine for many times will cause poor drug compliance

Method used

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  • Glutathione enteric-coated pellet and preparation method thereof
  • Glutathione enteric-coated pellet and preparation method thereof
  • Glutathione enteric-coated pellet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of 100mg glutathione enteric-coated pellets

[0040]

[0041] 1) Screen and weigh various materials according to the above table;

[0042] 2) Take the weighed hypromellose and add water, stir and dissolve to obtain a hypromellose solution A with a concentration of 5% (W / W);

[0043]3) Take the weighed sucrose and add water, stir and dissolve to obtain a 2% (W / W) sucrose solution B;

[0044] 4) Preparation of the coating liquid of the main drug layer (liquid C): according to the proportions of sucrose and hypromellose weighed respectively in the main drug layer and the isolation layer, take an appropriate amount of solution A and solution B and mix well, add the amount of glutathione, stirred for more than 20 minutes, that is;

[0045] 5) Preparation of the isolation layer coating solution (liquid D): take the remaining solution A and solution B and mix evenly, add the weighed talcum powder, and stir for more than 20 minutes to obtain the product;

[00...

Embodiment 2

[0052] Preparation of 100mg glutathione enteric-coated capsules

[0053] Prepare glutathione enteric-coated pellets according to the method and amount in Example 1, the difference is that each technical process parameter in the 7th) step is:

[0054] technical indicators

[0055] Distribution plate differential pressure

[0056] The glutathione content in the pellets prepared above was analyzed and filled into capsules to obtain 100 mg glutathione-containing capsules.

Embodiment 3

[0058] Preparation of glutathione enteric-coated pellets

[0059] In the present embodiment, each step and its technical process parameters are basically the same as those in Example 1, the difference being that the quantities of various materials are as follows:

[0060]

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Abstract

The invention discloses a glutathione enteric-coated pellet and preparation method thereof. The glutathione enteric-coated pellet comprises a core including glutathione and a enteric-coated layer from the inside out. Through the preparation method, main drug of the product of the invention is not released in acid and quickly released after entering into small intestine, thereby preventing the main drug from damage by gastric acid.

Description

technical field [0001] The invention relates to a glutathione pharmaceutical preparation, in particular to a glutathione enteric-coated pellet and a preparation method thereof. Background technique [0002] Glutathione is a tripeptide composed of glutamic acid, cysteine ​​and glycine. At present, glutathione drugs have been developed artificially, which are widely used in clinical practice. In addition to using its sulfhydryl group to chelate heavy metals, fluorides, mustard gas and other toxin poisoning, it is also used as an adjuvant treatment for hepatitis, hemolytic diseases, keratitis, cataracts and retinal diseases. In addition, glutathione also has the following therapeutic and preventive effects: detoxification, radiation sickness and radiation protection, liver protection, anti-allergy, improvement of the course and symptoms of certain diseases, beauty and skin care, increased vision and eye diseases, anti-aging, etc. effect. [0003] Glutathione was first develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/48A61K38/06A61K47/38A61P39/02A61P1/16A61P7/00A61P27/02A61P27/12
Inventor 马维波曹天海冯朴纯
Owner KUNMING JIDA PHARMA
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