Glutathione enteric-coated pellet and preparation method thereof
A technology of glutathione and enteric-coated pellets, which is applied in the directions of tripeptide components, pharmaceutical formulations, and inactive medical preparations, etc., can solve problems such as poor drug compliance, achieve uniform size and ensure stability , the effect of large distribution area
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Embodiment 1
[0039] Preparation of 100mg glutathione enteric-coated pellets
[0040]
[0041] 1) Screen and weigh various materials according to the above table;
[0042] 2) Take the weighed hypromellose and add water, stir and dissolve to obtain a hypromellose solution A with a concentration of 5% (W / W);
[0043]3) Take the weighed sucrose and add water, stir and dissolve to obtain a 2% (W / W) sucrose solution B;
[0044] 4) Preparation of the coating liquid of the main drug layer (liquid C): according to the proportions of sucrose and hypromellose weighed respectively in the main drug layer and the isolation layer, take an appropriate amount of solution A and solution B and mix well, add the amount of glutathione, stirred for more than 20 minutes, that is;
[0045] 5) Preparation of the isolation layer coating solution (liquid D): take the remaining solution A and solution B and mix evenly, add the weighed talcum powder, and stir for more than 20 minutes to obtain the product;
[00...
Embodiment 2
[0052] Preparation of 100mg glutathione enteric-coated capsules
[0053] Prepare glutathione enteric-coated pellets according to the method and amount in Example 1, the difference is that each technical process parameter in the 7th) step is:
[0054] technical indicators
[0055] Distribution plate differential pressure
[0056] The glutathione content in the pellets prepared above was analyzed and filled into capsules to obtain 100 mg glutathione-containing capsules.
Embodiment 3
[0058] Preparation of glutathione enteric-coated pellets
[0059] In the present embodiment, each step and its technical process parameters are basically the same as those in Example 1, the difference being that the quantities of various materials are as follows:
[0060]
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