Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Memantine hydrochloride capsule sustained-release preparation and preparation method for same

A technology of memantine hydrochloride and sustained-release capsules is applied in the directions of pharmaceutical formulation, drug delivery, amine active ingredients, etc., which can solve the problems of inability to effectively control the drug release amount, poor safety, and poor effectiveness, and achieves good content uniformity, Short coating time and less irritating effect

Inactive Publication Date: 2012-07-11
无锡万全医药技术有限公司
View PDF1 Cites 18 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a memantine hydrochloride sustained-release capsule, which can overcome the disadvantages that the current common dosage forms of memantine hydrochloride cannot effectively control the drug release, resulting in poor safety and effectiveness.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Memantine hydrochloride capsule sustained-release preparation and preparation method for same
  • Memantine hydrochloride capsule sustained-release preparation and preparation method for same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]

[0031] Raw material name content

[0032]

[0033] Memantine Hydrochloride 2.0g

[0034] Sucrose spherical particles (15-30 mesh) 250g

[0035] Eudragit RS 100 25g

[0036] Eudragit RL 100 9g

[0037] Triethyl citrate 2g

[0038] Povidone K30 2g

[0039] Talc powder 15g

[0040] Sucrose 15g

[0041]

[0042] Preparation: Take the prescribed amount of sucrose, add the same amount of water to make 50% syrup, add the prescribed amount of memantine hydrochloride, mix well, and form a suspension for later use; take another prescribed amount of sucrose spherical particles, put it in a high-efficiency coating pan, adjust The temperature of the air inlet is 30-40°C, and the above suspension is evenly sprayed on the spherical sucrose particles according to the coating process, dried at 50-60°C for 8 hours, and passed through a 20-mesh sieve to obtain ...

Embodiment 2

[0044]

[0045] Preparation: Take the prescribed amount of sucrose, add the same amount of water to make 50% syrup, add the prescribed amount of memantine hydrochloride, mix well, and form a suspension for later use; take another prescribed amount of microcrystalline cellulose spherical particles, and put it in a high-efficiency coating pan In the process, adjust the air inlet temperature to 30-40°C, spray the above-mentioned suspension evenly on the microcrystalline cellulose spherical particles according to the coating process, dry at 50-60°C for 8 hours, and pass through a 20-mesh sieve to obtain drug-containing spherical particles , stand-by; take the prescription amount of Eudragit RS 100, Eudragit RL 100, polyethylene glycol 6000 plus the prescription amount of ethanol to dissolve, spray evenly on the above-mentioned drug-containing spherical particles according to the coating process, dry at 50-60 ° C for 8 hours, pass Sieve through a 15-mesh sieve to obtain sustained...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a memantine hydrochloride capsule sustained-release preparation, wherein the preparation is composed of two parts, namely, immediate-release grains and sustained-release grains; the sustained-release part is composed of a blank pellet core, a medicine layer and a release control layer; and the immediate-release part is composed of a blank pellet core and a medicine layer. The capsule is uniform in content, good in release effect, stable in blood concentration, good for reducing the toxic and side effects of medicines, and is capable of being used for treating moderate-to-severe Alzheimer-type dementia, and the medicine-taking times of the patient are reduced,.

Description

technical field [0001] The invention relates to an oral sustained-release medicine, in particular to a memantine hydrochloride sustained-release capsule and a preparation method thereof. technical background [0002] Memantine hydrochloride is the first new drug for the treatment of moderate to severe Alzheimer's dementia (senile dementia). It is a unique NMDA receptor antagonist that can block calcium ion channels and reduce glutamatergic activity Activation, and attenuation of increased background noise, the resulting signal is recognized and then processed. That is, it prevents the excessive influx of calcium ions with neurotoxicity, thereby improving the symptoms of dementia. [0003] Memantine hydrochloride can significantly improve the cognitive function and behavioral ability of patients with moderate to severe dementia, with few adverse reactions in long-term treatment, good tolerance and safety, and few drug-drug interactions. It can improve the patient's cognitio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/13A61P25/28
Inventor 马文武
Owner 无锡万全医药技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products