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Micro needle transdermal patch for treating osteoarthritis and preparation method thereof

A technology for transdermal drug delivery and osteoarthritis, applied in the field of traditional Chinese medicine, can solve the problems of small drug storage and short sustained release time, and achieve the effects of prolonging drug efficacy, avoiding repeated administration, and improving drug loading efficiency.

Inactive Publication Date: 2016-10-12
赵晶晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the prior art, and provide a microneedle transdermal drug delivery patch for the treatment of osteoarthritis and a preparation method thereof, so as to solve the problems of common Chinese medicine liniments, liniments, patches and microneedle patches. It is proposed due to technical problems such as small drug storage capacity and short sustained release time during preparation or practical application

Method used

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  • Micro needle transdermal patch for treating osteoarthritis and preparation method thereof
  • Micro needle transdermal patch for treating osteoarthritis and preparation method thereof
  • Micro needle transdermal patch for treating osteoarthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Such as Figure 1~4 As shown, the substrate 2 is located in the middle of the ointment blank paste and the ointment back paste, and the front side of the substrate forms many microneedles 6 on its surface after laser-etching, and these microneedles 6 form a group of rectangular microneedles on the substrate 2 array. The substrate 2 is made of a porous silicon material with a porous structure. The tip of the microneedle 6 is provided with a spike 5, and the microneedle 6 is vertically fixed on the substrate 2. There is a microneedle gap 7 between the microneedles 6, and the medicine is stored in the microneedle. Among the gap 7 and the porous structure, the back side of the substrate 2 is a plane, and the back side of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, and the inner surface of the ointment back sticker 3 is covered on the front surface of the substrate 2, and the inner surface of the ointment blank sticker The surface 1 and t...

Embodiment 2

[0028] In this embodiment, the material used for the substrate 2 is porous polystyrene, and the substrate 2 has a porous structure. After the front of the substrate undergoes laser-etching, many microneedles 6 are formed on the surface, and these microneedles 6 are formed on the substrate 2. A group of rectangular microneedle arrays. The microneedle array is formed by arranging a plurality of microneedles 6 in order. The tip of the microneedles 6 is provided with a spiked portion 5. The microneedle array is vertically fixed on the substrate 2. Between the microneedles 6 There is a microneedle gap 7 between them, and the medicine is stored in the microneedle gap 7 and the porous structure. The back side of the substrate 2 is flat, and the back side of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, and the ointment back sticker 3 covers the inner surface of the substrate 2. On the front side, the size and shape of the inner surface 1 of the ointme...

Embodiment 3

[0030]In Embodiment 3, the material used for the substrate 2 is a porous titanium material, and the substrate 2 has a porous structure. The front of the substrate 2 is provided with a microneedle array, and the microneedle array is formed by a plurality of microneedles 6 arranged in sequence. There are spikes 5 at the top of the blade, and the size of the spikes 5 can be adjusted according to the actual needs of laser-etching precision. The microneedle array is vertically fixed on the substrate 2, and there are microneedle gaps 7 between the microneedles 6. Stored in the microneedle gap 7 and the porous structure, the back of the substrate 2 is flat, the back of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, the inner surface of the ointment back sticker 3 is covered on the front of the substrate 2, and the ointment The inner surface 1 of the blank sticker and the inner surface of the ointment back sticker are fixedly connected by pasting. There...

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Abstract

The invention discloses a micro needle transdermal patch for treating osteoarthritis and a preparation method thereof. The micro needle transdermal patch is prepared from bark of oriental variegated coralbean, radix achyranthis bidentatae, tinospora sinensis(Lour.)Merr., caulis spatholobi, radix clematidis, rhizoma homalomenae, herba lycopodii, lignum sappan, raw folium artemisiae argyi, herbs of tuberculate speranskia, rhizoma corydalis, seeds of peppertree pricklyash and tacrolimus. The patch is composed of a base plate, medicament, an ointment blank patch body and an ointment back patch body, the front face of the base plate is provided with a plurality of micro needles, micro needle gaps are formed among the micro needles, the medicament is stored in the micro needle gaps and a porous structure, the back face of the base plate is a plane and is pasted to the inner surface of the ointment blank patch body, the inner surface of the ointment back patch body is arranged on the front face of the base plate in a covering mode, and the inner surface of the ointment blank patch body and the inner surface of the ointment back patch body are fixedly connected in a pasting mode. The invention further discloses preparation steps of the micro needle transdermal patch. The micro needle transdermal patch has the advantages of being good in curative effect, quick in effect initiating, nearly free of damage to human skin and free of toxic or side effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a compound traditional Chinese medicine microneedle transdermal drug delivery patch for treating osteoarthritis and a preparation method thereof. Background technique [0002] Osteoarthritis, also known as degenerative joint disease, osteoarthritis, senile arthritis, hypertrophic arthritis, etc., is due to the degeneration and degeneration of soft tissues such as cartilage, intervertebral discs, and ligaments that make up the joint, and changes in the synovial membrane at the edge of the joint, causing subsequent Episodic osteoarthritis, osteoarthritis belongs to the category of "gubi" in traditional Chinese medicine. Gubi is caused by the lack of righteousness of the human body or the deficiency of liver and kidney, the muscles and bones are lost in nourishment, and the external evils such as wind, cold, and damp invade the meridians, resulting in the blockage of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K9/70A61K9/51A61P19/08A61P19/02A61P29/00A61K31/436
CPCA61K36/48A61K9/0002A61K9/0021A61K9/5123A61K9/7023A61K31/436A61K36/11A61K36/185A61K36/21A61K36/282A61K36/47A61K36/486A61K36/534A61K36/59A61K36/66A61K36/716A61K36/758A61K36/888A61K2300/00
Inventor 赵晶晶方瑞阳巧凤陈小葵陈莉婧
Owner 赵晶晶
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