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Veterinary suspension containing amoxicillin and baicalein and its preparation method

A technology of amoxicillin and suspension, which is applied in the field of animal husbandry pharmaceutical preparations, can solve the problems of no treatment plan and drugs, increased proportion of drug-resistant strains, high price, etc., to save manpower and material resources, release slowly, and reduce incidence Effect

Active Publication Date: 2018-08-24
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Single use of amoxicillin or other antibiotics in the treatment of mastitis caused by Staphylococcus aureus is getting worse and worse
Although Pfizer in the U.S. has produced Suo Nuo breast infusion with amoxicillin, clavulanic acid and prednisolone as the main agents and Boehringer Ingelheim in Germany has produced ampicillin and kanamycin as the main Eusporin breast perfusion agent, but the price of both is very expensive, which brings huge economic burden to farmers
For highly drug-resistant MRSA infection, there is no specific treatment plan and drugs in clinical practice, and under the pressure of antibiotic selection, the proportion of drug-resistant strains will continue to increase

Method used

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  • Veterinary suspension containing amoxicillin and baicalein and its preparation method
  • Veterinary suspension containing amoxicillin and baicalein and its preparation method
  • Veterinary suspension containing amoxicillin and baicalein and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Embodiment 1, preparation contains the compound suspension of amoxicillin baicalein

[0090] Its formula is as follows:

[0091]

[0092]

[0093] The specific preparation method is as follows:

[0094] 1) Add the hydrogenated castor oil and propyl gallate in the formula amount to 0.5L soybean oil, heat and stir to completely dissolve to obtain liquid A, and set aside;

[0095] 2) Pour 8L of soybean oil into the colloid mill, start the colloid mill, slowly add the prescribed amount of amoxicillin, grind for about 5 minutes, slowly add wetting agent and liquid A, and continue grinding for about 15 minutes.

[0096] 3) Slowly add the prescribed amount of baicalein, add soybean oil to 10L, and continue grinding for 15 minutes.

[0097] 4) Check the fineness of the particles: no less than 90% of the particles below 15 μm, no less than 95% of the particles below 20 μm, no particles exceeding 50 μm, stop grinding, mix, fill, seal, sterilize, and get The veterinary su...

Embodiment 2

[0098] Embodiment 2, preparation contains the compound suspension of amoxicillin baicalein

[0099] Its formula is as follows:

[0100]

[0101] The specific preparation method is as follows:

[0102] 1) Add the hydrogenated castor oil and propyl gallate in the formula amount to 0.5L soybean oil, heat and stir to completely dissolve to obtain liquid A, and set aside;

[0103] 2) Pour 8L of soybean oil into the colloid mill, start the colloid mill, slowly add the prescribed amount of amoxicillin, grind for about 5 minutes, slowly add wetting agent and liquid A, and continue grinding for about 15 minutes.

[0104] 3) Slowly add the prescribed amount of baicalein, add soybean oil to 10L, and continue grinding for 15 minutes.

[0105] 4) Check the fineness of the particles: the particles with a particle size below 15 μm shall not be less than 90%, the particles below 20 μm shall not be less than 95%, and no particles exceeding 50 μm meet the requirements. Stop grinding, mix, ...

Embodiment 3

[0106] Embodiment 3, preparation contains the compound suspension of amoxicillin baicalein

[0107] Its formula is as follows:

[0108]

[0109]

[0110] The specific preparation method is as follows:

[0111] 1) Add the hydrogenated castor oil and propyl gallate in the formula amount to 0.5L soybean oil, heat and stir to completely dissolve to obtain liquid A, and set aside;

[0112] 2) Pour 4L soybean oil and 4L triacetin into the colloid mill, start the colloid mill, slowly add the prescribed amount of amoxicillin, grind for about 5 minutes, slowly add wetting agent and liquid A, and continue grinding for about 15 minutes.

[0113] 3) Slowly add the prescribed amount of baicalein, add soybean oil to 10L, and continue grinding for 15 minutes.

[0114] 4) Check the fineness of the particles: the particles with a particle size below 15 μm shall not be less than 90%, the particles below 20 μm shall not be less than 95%, and no particles exceeding 50 μm meet the requirem...

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Abstract

The invention discloses a veterinary mixed suspension with amoxicillin and baicalein and a preparation method of the veterinary mixed suspension. The veterinary mixed suspension is formed by dispersing active components in a dispersion medium, wherein the active components include amoxicillin and baicalein. Each 100 mL of mixed suspension is prepared from 3-10 g of amoxicillin, 3-10 g of baicalein and the balance dispersing medium. According to the mixed suspension, oily solvent is adopted as the dispersing medium of the preparation, the problem that amoxicillin is easy to degrade in an aqueous solution is solved, and the problem that medicine is slowly released in an oily mixed suspension is solved; for time-depending antibiotics, T>MIC is prolonged, effective acting time is prolonged, a user only needs to consecutively take medicine three times at time intervals of 12 hours, repeated dosage is avoided, and manpower and material are saved. According to the veterinary mixed suspension, the mixed suspension is obtained by dispersing amoxicillin and baicalein in the dispersing medium through a dispersing method, adding suspending agent, wetting agent and antioxidant and grinding the materials through a colloid mill, and the mixed suspension is simple in production process, reduces cost and is easy to obtain industrially.

Description

technical field [0001] The invention relates to a veterinary suspension containing amoxicillin and baicalein and a preparation method thereof, belonging to the field of animal husbandry pharmaceutical preparations. Background technique [0002] Cow mastitis is one of the most important diseases of dairy cows hindering the development of dairy farming industry, resulting in serious economic losses. At present, there are about 220 million dairy cows in the world, the incidence rate of which is 20-60%, and the global economic loss caused by dairy cow mastitis can reach 35 billion US dollars every year. However, in many areas of my country, the incidence of subclinical mastitis is about 50%, and the economic loss of 135 million yuan can be caused by subclinical mastitis alone, and the incidence of mastitis in my country is generally high. [0003] Staphylococcus aureus is the most common pathogen of cow mastitis, accounting for about 5-50%. It mainly damages the function of ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/43A61K47/44A61K47/14A61P31/04A61P15/14A61K31/352
CPCA61K9/10A61K31/352A61K31/43A61K47/14A61K47/44A61K2300/00
Inventor 肖希龙沈建忠汤树生钱民怡
Owner CHINA AGRI UNIV
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