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Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method

A compound traditional Chinese medicine and transdermal drug delivery technology, applied in the field of traditional Chinese medicine, can solve the problems of short sustained release time, small drug storage, and achieve the effects of no toxic side effects, quick effect, and improved drug loading efficiency

Inactive Publication Date: 2016-10-12
凌云
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the deficiencies in the prior art, and provide a kind of compound Chinese medicine microneedle transdermal drug delivery patch for the treatment of frozen shoulder and its preparation method, to solve the problem of common Chinese medicine liniment, liniment, patch and microneedle patch It is proposed due to technical problems such as small drug storage capacity and short sustained release time during preparation or practical application

Method used

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  • Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method
  • Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method
  • Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method

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Experimental program
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Effect test

Embodiment 1

[0032] Such as Figure 1-4 As shown, the substrate 2 is located in the middle of the ointment blank paste and the ointment back paste, and the front side of the substrate forms many microneedles 6 on its surface after laser-etching, and these microneedles 6 form a group of rectangular microneedles on the substrate 2 array. The substrate 2 is made of a porous silicon material with a porous structure. The tip of the microneedle 6 is provided with a spike 5, and the microneedle 6 is vertically fixed on the substrate 2. There is a microneedle gap 7 between the microneedles 6, and the medicine is stored in the microneedle. Among the gap 7 and the porous structure, the back side of the substrate 2 is a plane, and the back side of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, and the inner surface of the ointment back sticker 3 is covered on the front surface of the substrate 2, and the inner surface of the ointment blank sticker The surface 1 and t...

Embodiment 2

[0034] In this embodiment, the material used for the substrate 2 is porous polystyrene, and the substrate 2 has a porous structure. After the front of the substrate undergoes laser-etching, many microneedles 6 are formed on the surface, and these microneedles 6 are formed on the substrate 2. A group of rectangular microneedle arrays. The microneedle array is formed by arranging a plurality of microneedles 6 in order. The tip of the microneedles 6 is provided with a spiked portion 5. The microneedle array is vertically fixed on the substrate 2. Between the microneedles 6 There is a microneedle gap 7 between them, and the medicine is stored in the microneedle gap 7 and the porous structure. The back side of the substrate 2 is flat, and the back side of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, and the ointment back sticker 3 covers the inner surface of the substrate 2. On the front side, the size and shape of the inner surface 1 of the ointme...

Embodiment 3

[0036]In Embodiment 3, the material used for the substrate 2 is a porous titanium material, and the substrate 2 has a porous structure. The front of the substrate 2 is provided with a microneedle array, and the microneedle array is formed by a plurality of microneedles 6 arranged in sequence. There are spikes 5 at the top of the blade, and the size of the spikes 5 can be adjusted according to the actual needs of laser-etching precision. The microneedle array is vertically fixed on the substrate 2, and there are microneedle gaps 7 between the microneedles 6. Stored in the microneedle gap 7 and the porous structure, the back of the substrate 2 is flat, the back of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, the inner surface of the ointment back sticker 3 is covered on the front of the substrate 2, and the ointment The inner surface 1 of the blank sticker and the inner surface of the ointment back sticker are fixedly connected by pasting. There...

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Abstract

The invention discloses a compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and a preparation method. The compound traditional Chinese medicine micro needle transdermal patch is prepared from medical materials including poria, manyflower solomonseal rhizomes, cortex eucommiae, cortex cinnamomi, herba schizonepetae, rhizoma chuanxiong, roots or stems of smoothfruit ventilago, Japanese creeper, leaves or roots of dentate wampee, silvery aleuritopteris and radix angelicae pubescentis and auxiliaries including polysorbate-80, granulesten, glycerin monostearate and tacrolimus. The patch is composed of a base plate, medicament, an ointment blank patch body and an ointment back patch body, the front face of the base plate is provided with a plurality of micro needles, micro needle gaps are formed among the micro needles, the medicament is stored in the micro needle gaps and a porous structure of the base plate, the back face of the base plate is pasted to the inner surface of the ointment blank patch body, the inner surface of the ointment back patch body is arranged on the front face of the base plate in a covering mode, and the inner surface of the ointment blank patch body and the inner surface of the ointment back patch body are fixedly connected in a pasting mode. The invention further discloses preparation steps of the micro needle transdermal patch. The micro needle transdermal patch has the advantages of being precise in medicine composition, free of pain, capable of being released slowly, efficient and convenient to apply.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a compound traditional Chinese medicine microneedle transdermal drug delivery patch for treating frozen shoulder and a preparation method thereof. Background technique [0002] Frozen shoulder is chronic aseptic inflammation of soft tissues such as muscles, tendons, bursa and joint capsule around the shoulder joint. Inflammation leads to adhesions inside and outside the joint, which affects the movement of the shoulder joint. The lesions are characterized by extensive pain, extensive functional limitation, and extensive tenderness. The full name of frozen shoulder is periarthritis of the shoulder. [0003] From the perspective of Western medicine, the clinical characteristics of this disease are more common in the middle-aged and above people whose shoulder activities gradually decrease. Western medicine mainly treats frozen shoulder conservatively. Such as oral ant...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/70A61K9/51A61P19/02A61P29/00
CPCA61K36/8969A61K9/0002A61K9/0021A61K9/5123A61K9/7023A61K36/076A61K36/11A61K36/232A61K36/236A61K36/46A61K36/54A61K36/72A61K36/75A61K36/87A61K2236/331A61K2236/333A61K2300/00
Inventor 凌云赵晶晶
Owner 凌云
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