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Traditional Chinese medicine microneedle transdermal delivery paster for treatment of fracture and soft tissue injury and preparation method thereof

A technology for treating soft tissue injuries and treating fractures, which can be used in pharmaceutical formulations, bone diseases, microcapsules, etc. It can solve the problems of small drug storage and short sustained release time, and achieve prolonged drug efficacy, no toxic side effects, and improved drug loading efficiency. Effect

Inactive Publication Date: 2016-11-16
安徽省小山卫生材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies in the prior art, to provide a kind of traditional Chinese medicine microneedle transdermal drug delivery patch for the treatment of fracture soft tissue injury and its preparation method, to solve the problem of common Chinese medicine liniment, liniment, patch and microneedle patch It is proposed due to technical problems such as small drug storage capacity and short sustained release time during preparation or practical application

Method used

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  • Traditional Chinese medicine microneedle transdermal delivery paster for treatment of fracture and soft tissue injury and preparation method thereof
  • Traditional Chinese medicine microneedle transdermal delivery paster for treatment of fracture and soft tissue injury and preparation method thereof
  • Traditional Chinese medicine microneedle transdermal delivery paster for treatment of fracture and soft tissue injury and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0030] Such as Figure 1~4 As shown, the substrate 2 is located in the middle of the ointment blank paste and the ointment back paste, and the front side of the substrate forms many microneedles 6 on its surface after laser-etching, and these microneedles 6 form a group of rectangular microneedles on the substrate 2 array. The substrate 2 is made of a porous silicon material with a porous structure. The tip of the microneedle 6 is provided with a spike 5, and the microneedle 6 is vertically fixed on the substrate 2. There is a microneedle gap 7 between the microneedles 6, and the medicine is stored in the microneedle. Among the gap 7 and the porous structure, the back side of the substrate 2 is a plane, and the back side of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, and the inner surface of the ointment back sticker 3 is covered on the front surface of the substrate 2, and the inner surface of the ointment blank sticker The surface 1 and t...

Embodiment 2

[0032]In this embodiment, the material used for the substrate 2 is porous polystyrene, and the substrate 2 has a porous structure. After the front of the substrate undergoes laser-etching, many microneedles 6 are formed on the surface, and these microneedles 6 are formed on the substrate 2. A group of rectangular microneedle arrays. The microneedle array is formed by arranging a plurality of microneedles 6 in order. The tip of the microneedles 6 is provided with a spiked portion 5. The microneedle array is vertically fixed on the substrate 2. Between the microneedles 6 There is a microneedle gap 7 between them, and the medicine is stored in the microneedle gap 7 and the porous structure. The back side of the substrate 2 is flat, and the back side of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, and the ointment back sticker 3 covers the inner surface of the substrate 2. On the front side, the size and shape of the inner surface 1 of the ointmen...

Embodiment 3

[0034] In Embodiment 3, the material used for the substrate 2 is a porous titanium material, and the substrate 2 has a porous structure. The front of the substrate 2 is provided with a microneedle array, and the microneedle array is formed by a plurality of microneedles 6 arranged in sequence. There are spikes 5 at the top of the blade, and the size of the spikes 5 can be adjusted according to the actual needs of laser-etching precision. The microneedle array is vertically fixed on the substrate 2, and there are microneedle gaps 7 between the microneedles 6. Stored in the microneedle gap 7 and the porous structure, the back of the substrate 2 is flat, the back of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, the inner surface of the ointment back sticker 3 is covered on the front of the substrate 2, and the ointment The inner surface 1 of the blank sticker and the inner surface of the ointment back sticker are fixedly connected by pasting. Ther...

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Abstract

The invention discloses a traditional Chinese medicine microneedle transdermal delivery paster for treatment of fracture and soft tissue injury and a preparation method thereof. The paster comprises the following raw materials: radix paeoniae rubra, nux vomica, safflower, tuberculate speranskia herb, epimedium, pseudo-ginseng, Radix Astragali, radix sileris, herba lycopi, eucommia, Chinese angelica, rhizoma drynariae, dragon's blood, mint and accessories comprising polysorbate-80, soybean lecithin and glycerin monostearate. The paster comprises a substrate, a medicament, an ointment blank plaster and an ointment back plaster; the front side of the substrate is provided with a plurality of microneedles with gaps therebetween; the medicament is stored in the microneedle gaps and the porous structure of the substrate; the back of the substrate is pasted on the inner surface of the ointment blank plaster; the inner surface of the ointment back plaster covers on the front side of the substrate; the inner surface of the ointment blank plaster and the inner surface of the ointment back plaster are fixedly connected by adhesion. The invention discloses the preparation steps. The paster has the advantages of good therapeutic effect, quick effectiveness, no damage to human skin and no toxic side effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine microneedle transdermal drug delivery patch for treating fracture soft tissue injury and a preparation method thereof. Background technique [0002] Fracture and soft tissue injury are common diseases in traumatology. Fracture refers to a disease in which bone is partially or completely broken due to trauma or pathology. The main clinical manifestations are localized pain and tenderness at the fracture site, local swelling and ecchymosis, or complete loss of limb function, and limb deformities and abnormal activities may still occur in complete fractures. Soft tissue injury refers to the skin, subcutaneous superficial and deep fascia, muscle, tendon, tendon sheath, ligament, joint capsule, synovial bursa, intervertebral disc, peripheral neurovascular and other tissues of the human body caused by various acute trauma or chronic strain, as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K36/896A61K9/70A61K9/51A61P19/08A61P19/04
CPCA61K36/71A61K9/0021A61K9/5123A61K9/7023A61K36/126A61K36/185A61K36/232A61K36/238A61K36/258A61K36/286A61K36/296A61K36/46A61K36/47A61K36/481A61K36/53A61K36/534A61K36/56A61K36/65A61K36/889A61K36/896A61K2236/331A61K2236/333A61K2236/53A61K2300/00
Inventor 周小山胡德斌雷激
Owner 安徽省小山卫生材料有限公司
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