The invention discloses a preparation method of
sericin hydrogel, the method is as follows: first, weighting domestic silkworm
fibroin deletion form
mutation variety silkworm cocoon for LiBr or LiCl extraction and
dialysis and purification to obtain a non-degradable
sericin water solution with a
mass percentage concentration of 0.1-4%; concentrating the
sericin water solution to 1.5-10%, adding a cross-linking agent to the concentrated sericin water solution (wherein 2-500muL of the cross-linking agent is added into each L of the sericin water solution), fully mixing, and placing at 4-45 DEG C for 5 seconds to 36 hours to obtain the sericin hydrogel. The sericin hydrogel has
biological activity and multiple functions, can be used as carrying growth factors, drugs and
cell carriers treatment, and can be applied in repair of a variety of
soft tissue injuries, including but not limited to
skin damages,
muscle damages, injuries of
blood vessel, nerve injuries, myocardial damages, and the like, and treatment of diseases.