The invention relates to an external application pharmaceutical composition for treating osteoproliferation which comprises semen strychni, Sichuan aconite root, Kusnezoff monkshood root, jack-in-the-pulpit tuber, pinellia tuber, white pepper, buthus martensi karsch, Cinnamomum cassia, white mustard seed, datura flower, wood louse, dragon's blood resin, frankincense, myrrh, notoginseng, asaryl, black-tail snake, cassia twig, mulberry twigs, Chinese ephedra, large-leaf gentian root, peach kernels, safflower, ledebouriella root, spatholobus stem, Chinese angelica root, notopterygium root, pubescent angelica root, campeachy wood, earthworm, Clematis chinensis, curcuma longa, achyranthes root, pawpaw, Ligusticum wallichii, speranskia herb, burred tuber, Japanese yam, zedoary, pyrola, garden balsam seed and hairy birthwort.