62 results about "Soft tissue graft" patented technology

An implant for repairing soft tissue injuries is provided comprising at least one channel for receiving a soft tissue graft such as a tendon, ligament, or other soft tissue, to be implanted in a patient. The implant assembled with the graft is designed to fit into a bony defect, such as a graft tunnel, formed in bone of a patient. The implant can be biodegradable, and the implant-graft assembly has a pull-out strength sufficient to withstand everyday use during patient recovery.

Apparatus and methods for conditioning and pre-tensioning soft tissue grafts during joint repair surgery, such as during repair of the anterior cruciate ligament (ACL). The inventive apparatus is advantageously adapted and configured so as to enable a surgeon to independently apply a desired tensile load to individual graft strands or graft bundles of a multi-strand tissue graft. The inventive methods enable each graft strand or bundle to be properly tensioned so as to both “condition” the graft to prevent subsequent stretching, relaxation or elongation following surgery, which can destabilize the joint, and to pre-tension each graft strand or bundle to a predetermined amount so that each contributes to the strength and stability of the joint, thus resulting in a stronger and more durable joint. The tensioning device is advantageously equipped with structure for attachment to a patient's limb during the conditioning and pre-tensioning procedure. It has multiple adjustable tension applicators that can be independently manipulated so as to apply a separate tensile load to one or more ends of a tissue graft strand attached to each adjustable tension applicator.

A whip stitched graft construct and method of formation. The whip stitched graft construct includes a plurality of tendon strand regions or soft tissue grafts placed together so that at least a portion of the plurality of the tendon strand regions are stitched together by employing multiple suture passes placed according to a whip stitching technique. Preferably, the multiple suture passes start at about the mid length of the plurality of tendon strand regions and are advanced toward one of the free ends of the tendon strands. The whip stitched graft construct is provided with at least two regions, one region formed of at least a plurality of tendon strand regions tied and whip stitched together, and the other region formed of untied segments of the plurality of tendon strands.

A graft construct formed of a plurality of single tendon strands or soft tissue grafts placed together so that at least a portion of one of the single tendon strands is wrapped around a portion of another of the single provided with at least two suturing, for example. The graft construct is provided with at least two regions, one region formed of at least a plurality of tendon strands tied together, and the other region formed of loose segments of the plurality of tendon strands.

A graft construct formed of a plurality of single tendon strands or soft tissue grafts placed together so that at least a portion of one of the single tendon strands is wrapped around a portion of another of the single tendon strands by employing suturing, for example. The graft construct is provided with at least two regions, one region formed of at least a plurality of tendon strands tied together, and the other region formed of loose segments of the plurality of tendon strands.

A system is disclosed for repairing and reconstructing an injured anterior cruciate ligament (ACL); This system may be used irrespective of the type of patient or the ACL graft selected. Means for performing single or multiple bundle reconstruction, primary ACL repair and physeal-sparing ACL reconstruction are disclosed. A guide for inside-out creation of a femoral tunnel independent of the tibial tunnel is also disclosed, as well as a series of implant options for tibial and femoral fixation of any bone-soft-tissue composite or soft-tissue-only graft.

A graft fixation device, system and method are disclosed for reconstruction or replacement of a ligament or tendon preferably wherein a soft tissue graft or a bone-tendon-bone graft is received and implanted in a bone tunnel. The graft fixation system includes a fixation device comprising a threaded body which is rotatably connected to a graft interface member. One embodiment of the implant / graft interface member includes an enclosed loop for holding a soft tissue graft. Another embodiment of the interface member includes a bone cage comprising a cage bottom and removable cage top to hold a bone block at one end of a bone-tendon-bone (BTB) graft. An additional embodiment of the interface member includes a one-piece bone cage which may be crimped or stapled to a bone block. The fixation device holds a graft in centered axial alignment in a bone tunnel. The body portion of the fixation device may be turned without imparting substantial twist to a graft attached to the device, due to the rotatable coupling between the threaded body and the interface member. The fixation device may be installed using a driver tool that has a shaft and an outer sleeve, wherein the driver may be used to twist the fixation device and independently exert a pushing or pulling force thereto. The graft fixation method may be used to install a fixation device by pulling or pushing it into a prepared bone tunnel while minimizing the possibility of abrasion or other damage to a graft attached to the fixation device.

The invention relates to compositions effective for the cleansing of mammalian soft tissue optionally attached to bones, and particularly the removal of blood deposits and bone marrow therefrom. The compsotions are composed of an aqueous solution containing as its essential ingredients a detergent having a functionality of the nature of a polyoxyethylene-23-lauryl either, a detergent having a functionality of the nature of exyethylated alkylphenol, and water, where the compositions are free from any membrane stabilizers. The present invention is also directed to a method and composition for cleaning cadaveric soft tissue optionally attached to bone to produce soft tissue grafts optionally attached to bone suitable for transplantation into a human. The present method involves removing bone marrow elements, blood deposits and any bacteria, virus or fungi contamination, from the donor bone and / or associated soft tissues.

A bone attachment apparatus and implantation system. The attachment device provides a screw with channels formed therein for implantation within a bone aperture. The channels are used as a torque transfer surface during implantation, and cooperate with a thread forming tap to enable screw implantation simultaneously with thread formation within the aperture. The tap can be used to form channels within the bone. A staple is coupled to the screw and the bone, utilizing the respective channels formed therein, to prevent rotation therebetween. The screw can also cooperate with the staple to secure a soft tissue graft.

Systems and methods for bone to bone, or soft tissue to bone, repairs without knot tying. The repair systems include self-cinching constructs which are tensionable and which include a flexible strand with a knotless, adjustable loop with at least one splice and a shuttle / pull device attached to the flexible strand. A final splice is formed by pulling on the shuttle / pull device subsequent to the knotless, adjustable loop being assembled with or secured to tissue (for example, a soft tissue graft or BTB graft), to allow desired tensioning of the graft to be fixated relative to the bone.

This application describes apparatuses and methods for musculoskeletal tissue engineering. Specifically, graft collar and scaffold apparatuses are provided for promoting fixation of musculoskeletal soft tissue to bone.This application provides for graft collars comprising biopolymer mesh and / or polymer-fiber mesh for fixing tendon to bone. In one aspect, the graft collar comprises more than one region, wherein the regions can comprise different materials configured to promote integration of and the regeneration of the interfacial region between tendon and bone.This application also provides for scaffold apparatuses and methods for fixing musculoskeletal soft tissue to bone. The scaffold apparatus is multiphasic, preferably triphasic, and each phase is configured promote growth and proliferation of a different cell and its associated tissue. In one aspect, the scaffold apparatus is triphasic, with phases comprising materials to promote growth and proliferation of fibroblasts, chondroblasts, and osteoblasts. In addition, an apparatus comprising two portions, each of said portion being the scaffold apparatus described above is provided, wherein each of said portion encases one end of a soft tissue graft. Further, a triphasic interference screw is provided.This application further provides apparatuses and methods for inducing formation of fibrocartilage comprising wrapping a graft collar with polymer-fiber mesh configured to apply compression to the graft collar. In another aspect, the polymer-fiber is applied directly to the graft to apply compression to the graft.

An anterior cruciate ligament (ACL) surgical repair technique involves the use of a single femoral and tibial tunnel and an implant that separates and positions two distinct bundles. This allows for the surgeon to create a more anatomic reconstruction with a procedure that is less technically demanding, can be performed using a transtibial or anteromedial approach, minimizes tunnel widening, and decreases operative time. The result is a strong fixation option for soft tissue grafts, with circumferential graft compression at the aperture, high pull-out strength, and ease of use. The graft bundles are positioned in a more anatomic orientation through the above noted single femoral and tibial tunnel.

A whip stitched graft construct and method of formation. The whip stitched graft construct includes a plurality of tendon strand regions or soft tissue grafts placed together so that at least a portion of the plurality of the tendon strand regions are stitched together by employing multiple suture passes placed according to a whip stitching technique. Preferably, the multiple suture passes start at about the mid length of the plurality of tendon strand regions and are advanced toward one of the free ends of the tendon strands. The whip stitched graft construct is provided with at least two regions, one region formed of at least a plurality of tendon strand regions tied and whip stitched together, and the other region formed of untied segments of the plurality of tendon strands.

A suspensory graft ligament fixation device is shown to be particularly suitable for maximizing the contact between a soft tissue graft and the bone tunnel prepared to receive the graft. The suspensory fixation device has an elongated anchor member adapted to be transversely situated at the exit of the bone tunnel. A loop member is suspended transversely from the anchor member and has a loop length which is adjustable. When a graft ligament is attached to the saddle end of the loop, the length of the loop member may be shortened to pull the graft member into the bone tunnel until it bottoms out at the floor of the bone tunnel.

Systems and methods for bone to bone, or soft tissue to bone, repairs without knot tying. The repair systems include self-cinching constructs which are tensionable and which include a flexible strand with a knotless, adjustable loop with at least one splice and a shuttle / pull device attached to the flexible strand. A final splice is formed by pulling on the shuttle / pull device subsequent to the knotless, adjustable loop being assembled with or secured to tissue (for example, a soft tissue graft or BTB graft), to allow desired tensioning of the graft to be fixated relative to the bone.

A stent tissue graft prosthesis (20) for repairing, excluding and / or reinforcing a vessel, duct and the like in a patient. The prosthesis includes an inner expandable stent (21) of which a tissue graft (24) and preferably a multilayered tissue construct (33) is disposed thereon for application to the host tissue of a vessel, duct and the like. The tissue construct includes an extracellular matrix material (36) such as small intestine submucosa (37) for remodeling the host tissue into the prosthesis. The prosthesis further includes an outer tubular member (25) such as an outer expandable stent (44) for retaining the tissue graft on the inner stent. The ends of the inner and outer stents are coincident with or extend beyond the ends of the tissue graft to prevent eversion or fold back of the tissue graft during withdrawal of a delivery catheter in a placement procedure.

Described herein is a simplified placement system and method for a tissue graft anchor by which a surgeon may introduce one or more sutures into a hole in a boney tissue, apply tension to the sutures to advance a soft tissue graft to a desired location, and then advance the anchor into the bone while maintaining suture tension and without introducing spin to the suture.

A method of soft tissue graft fixation to bone. A tunnel may be formed in a bone and a bio-compatible material may be placed in the tunnel in a liquid state using an insertion device. The soft tissue grafts may also be placed in the tunnel using the insertion device. The insertion device may serve as an internal mold to form a chamber for receiving a fastener. The liquid bio-compatible material may solidify around the insertion device, and the insertion device may be removed. Final fixation may be accomplished by inserting a fastener in the hardened bio-compatible material to apply a compressive force to compress the graft against the bone.

A technique and reconstruction system for ligament repair by determining the exact length of the graft to be secured within a first tunnel or socket (for example, a tibial tunnel) and a second tunnel or socket (for example, a femoral tunnel) for improved graft fixation. The exact length of the graft (soft tissue graft or BTB graft, for example) is determined with a measuring device, by measuring the length of a first socket in a first bone region (for example, a tibial socket), the length of a second socket in a second bone region (for example, a femoral socket), and the length of the intraarticular joint space between the two sockets in the two bone regions (for example, tibia and femur). The measuring device may consist of at least one flexible member (for example, suture) with at least one fixation device attached to the flexible member, the fixation device being either a sliding knot, a washer or a button.

Embodiments of the presently-disclosed subject matter provide composites that comprise a tissue graft and a biofilm dispersal agent. The tissue graft can be bone tissue graft, a soft tissue graft, or the like. In specific embodiments the tissue graft is a polyurethane graft and in other embodiments the tissue graft is bone particles, such as demineralized bone matrix. The biofilm dispersal agent can be one or more D-amino acids. The presently-disclosed subject matter further includes methods for treating tissue of a subject that comprise administering the present composites as well as methods for manufacturing the present composites.

A system and method for making an orthopedic repair by fixing a soft tissue graft to bone, utilizes an implant including a body wedge having first and second outwardly expandable wedge portions, a wing portion having outwardly expandable wings, and a deployment member which is movable distally into the implant to deploy the wedge portions and the wings into an expanded deployed orientation.

Described herein is a simplified placement system and method for a tissue graft anchor by which a surgeon may introduce one or more sutures into a hole in a boney tissue, apply a precise amount of tension to the sutures to advance a soft tissue graft to a desired location, and then advance the anchor into the bone, preferably while maintaining the requisite pre-determined suture tension and without introducing spin to the suture.

An apparatus and method for fixation of a soft tissue graft. The apparatus may include a member having a first surface and a second surface. Each of the surfaces extend a distance relative to one another. A member is operable to resist movement of the apparatus relative to an anatomical portion. An interference member may be provided to fixedly associate the apparatus with the anatomical structure.

Described herein is a simplified placement system and method for a tissue graft anchor by which a surgeon may introduce one or more sutures into a hole in a boney tissue, apply a precise amount of tension to the sutures to advance a soft tissue graft to a desired location, and then advance the anchor into the bone, preferably while maintaining the requisite pre-determined suture tension and without introducing spin to the suture. Particularly preferred embodiments allow for the one-handed operation. To that end, embodiments in which relative axial movement between the inner tensioning device and outer driver device is optionally physically constrained, for example by means of cooperating and / or compressive elements disposed in the respective hub and handle portions, are described herein.

The described invention provides soft tissue grafts, hard tissue grafts, and composite soft / hard tissue grafts and methods of producing such grafts. The grafts comprise a three-dimensional carrier matrix, a growth factor composition comprising an autologous platelet-rich fibrin and a cell culture composition comprising a culture medium, a population of cells suspended in the culture medium, and cells impregnated on or in a surface of osteoconductive particles.

The present invention provides a plasticized dehydrated or freeze-dried bone and / or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and / or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.

Using the simplified placement system and method for a tissue graft anchor of the present invention, a surgeon may introduce one or more sutures into a hole in a boney tissue, apply a precise amount of tension to the sutures to advance a soft tissue graft to a desired location, and then advance the anchor into the bone, preferably while maintaining the requisite pre-determined suture tension and without introducing spin to the suture. Particularly preferred embodiments of the present invention relate to multi-anchor constructs. Multi-anchor constructs of the present invention may employ threaded implants exclusively, push-in implants exclusively, or a combination of threaded and push-in implants.

Described herein is a simplified placement system and method for a tissue graft anchor by which a surgeon may introduce one or more sutures into a hole in a boney tissue, apply a precise amount of tension to the sutures to advance a soft tissue graft to a desired location, and then advance the anchor into the bone, preferably while maintaining the requisite pre-determined suture tension and without introducing spin to the suture. Particularly preferred embodiments allow for the placement of small diameter knotless anchors. For example, the implant placement system may include a cannulated tensioning device having disposed therein an elongate member of a suitably elastic metallic or polymeric material, such as nitinol, that includes at its distal end a loop of material suitable for suture retention. The implant placement system may further include high tensile strength knotless anchors provided with internal drive features that coordinate with torque-transmitting features unique to the driver devices of the present invention.