38 results about "Fibrocartilage" patented technology

Disclosed is an endoprosthetic implant for a human spinal disc. The structure of the implant allows it to be inserted posteriorly. This insertion is accomplished by performing a partial discectomy in the affected region. An intervertebral space is then created by removing the fibrocartilage between the facing surfaces of adjacent vertebrae. The implant is then inserted into the intervertebral space. The implant is thus adapted to replace damaged or worn intervertebral discs. Furthermore, the structure of the implant, and its posterior insertion, alleviate most spinal pathologies.

This application describes apparatuses and methods for musculoskeletal tissue engineering. Specifically, graft collar and scaffold apparatuses are provided for promoting fixation of musculoskeletal soft tissue to bone.This application provides for graft collars comprising biopolymer mesh and / or polymer-fiber mesh for fixing tendon to bone. In one aspect, the graft collar comprises more than one region, wherein the regions can comprise different materials configured to promote integration of and the regeneration of the interfacial region between tendon and bone.This application also provides for scaffold apparatuses and methods for fixing musculoskeletal soft tissue to bone. The scaffold apparatus is multiphasic, preferably triphasic, and each phase is configured promote growth and proliferation of a different cell and its associated tissue. In one aspect, the scaffold apparatus is triphasic, with phases comprising materials to promote growth and proliferation of fibroblasts, chondroblasts, and osteoblasts. In addition, an apparatus comprising two portions, each of said portion being the scaffold apparatus described above is provided, wherein each of said portion encases one end of a soft tissue graft. Further, a triphasic interference screw is provided.This application further provides apparatuses and methods for inducing formation of fibrocartilage comprising wrapping a graft collar with polymer-fiber mesh configured to apply compression to the graft collar. In another aspect, the polymer-fiber is applied directly to the graft to apply compression to the graft.

Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.

Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.

The present application discloses methods for repairing hyaline cartilage defects. The methods comprise a combination of introducing autologous bone mesenchymal stem cells to a joint, and applying to the joint a membrane comprising a polyester entangled with a polysaccharide. In some aspects, the bone mesenchymal stem cells are mesenchymal stem cells originating in bone underlying the joint. In these aspects, contact between the joint and the mesenchymal stem cells can be effected by introducing apertures through the bone using standard surgical techniques such as microfracture, abrasion, or drilling. Cartilage which forms in response to application of these methods is hyaline cartilage rather than fibrocartilage.

Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-εCaprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.

Disclosed is an endoprosthetic implant for a human spinal disc. The structure of the implant allows it to be inserted posteriorly. This insertion is accomplished by performing a partial discectomy in the affected region. An intervertebral space is then created by removing the fibrocartilage between the facing surfaces of adjacent vertebrae. The implant is then inserted into the intervertebral space. The implant is thus adapted to replace damaged or worn intervertebral discs. Furthermore, the structure of the implant, and its posterior insertion, alleviate most spinal pathologies.

A tissue engineered meniscus repair sheet and a preparation method thereof. The tissue engineered meniscus repair sheet prepared by the present invention includes a decellularized meniscus sheet, seed cells and growth factor slow-release carriers, wherein the two surfaces of the decellularized meniscus sheet are uniform Micro blind holes are distributed, and seed cells and slow-release growth factor carriers are compounded on both surfaces of the decellularized meniscus sheet. The micro-blind pores distributed on the decellularized meniscus sheet increase the area of ​​the scaffold material, which can be used as a storage pool for seed cells and slow-release carriers of growth factors, making them firmly attached and not easy to fall off; The carrier can release nutrients for a long time, improve the efficiency of cell expansion, maintain cell phenotype, inhibit cell aging, and promote the fusion of tissue engineering meniscus repair sheet and its own tissue. The prepared tissue engineered meniscus repair sheet has structural characteristics similar to natural meniscus, and can be used for repairing meniscus injury and inducing meniscus fibrocartilage tissue regeneration.

The present invention provides a method of using locally administered collagenase as a non-invasive means of enhancing cell release from the cartilage or fibrocartilage tissues adjacent to a disease or injury site. The subsequent migration of cells from these tissues into the lesion or wound, followed by deposition of the appropriate extracellular matrix, results in closure of the lesion or fusion of a tissue gap.

The present invention relates to a composition and a kit for regeneration and treatment of cartilage, preferably, fibrous cartilage or elastic cartilage and a regeneration method using the same. A composition and a kit for cartilage regeneration according to the present invention can be administered simply in a minimally invasive manner to a site in which fibrous cartilage or elastic cartilage isneeded to be regenerated or restored from injury, exhibit resistance to degradation enzymes without toxicity within the body, and are attached to or detained at and thus retained at the injured, administered site, whereby behavioral improvement can be brought about in surrounding cells, which leads to effectively inducing defected tissues of the meniscus to be regenerated. Therefore, the composition of the present invention is useful as a mediator for aiding the regeneration of biological tissue defected regions in the biomaterials field.

A fibrocartilage suturing device is provided to solve the problem where the conventional procedure of the surgery is inconvenient. The fibrocartilage suturing device includes a tube assembly, a tubular member, and an anchor. The tube assembly extends through the tube assembly and includes an insertion section. The movement member is coupled with the tube assembly and includes a thrust rod extending through the tubular member. The anchor is located at one end of the thrust rod and includes a body and at least two wings connected to the body is able to be folded and unfolded relative to the body. The body of the anchor is connected to an end of a thread. Another end of the thread is connected to the tubular member.

The present invention concerns a modular arthrodesis device, used to enable fusing of two contiguous vertebrae by development of bony tissues with replacement of fibrocartilaginous discs ensuring the bonding between the vertebrae of the vertebral column or the end of the latter, and including interchangeable types of fixation means. Intervertebral arthrodesis device designed to be inserted in an intervertebral space (E) separating the opposite plates (V0) of two adjacent vertebrae (V), characterised in that it comprises at least one structure called intervertebral cage (1) presenting the shape of a ring that mayor may not be open, in which at least one part, along the axis of the spine, has a lower height that the rest of this same cage and forms a small bar (12) crossed by at least one drilling (121, 122) of the axis approximately perpendicular to the plate (V0) of at least one of the adjacent vertebrae (V).

The present invention relates to a composition and a kit for regeneration and treatment of cartilage, preferably, fibrous cartilage or elastic cartilage and a regeneration method using the same. A composition and a kit for cartilage regeneration according to the present invention may be administered simply in a minimally invasive manner to a site in which fibrous cartilage or elastic cartilage is needed to be regenerated or restored from injury, exhibit resistance to degradation enzymes without toxicity within the body, and are attached to or detained at and thus retained at the injured, administered site, whereby behavioral improvement may be brought about in surrounding cells, which leads to effectively inducing defected tissues of the meniscus to be regenerated. Therefore, the composition of the present invention is useful as a mediator for aiding the regeneration of biological tissue defected regions in the biomaterials field.