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Bubble-type microneedle and preparation method therefor

A technology of microneedles and air bubbles, applied in the direction of microneedles, needles, and other medical devices, to achieve the effect of improving drug loading efficiency, simple method, and wide sources

Inactive Publication Date: 2016-10-26
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Soluble microneedles are used for drug loading, and there are many problems at present, such as: the size of ordinary microneedles is between 100 microns and 1000 microns, and the volume of each microneedle is between 5nL and 50nL. How to increase the drug loading capacity, Improving the drug loading efficiency is one of the existing problems; in addition, after the microneedle is inserted subcutaneously, it generally takes 1-3 minutes to dissolve and release the drug together during this period, so how to reduce the subcutaneous dissolution time and improve drug delivery? Drug efficiency is also an existing problem

Method used

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  • Bubble-type microneedle and preparation method therefor
  • Bubble-type microneedle and preparation method therefor
  • Bubble-type microneedle and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prepare PVA air bubble microneedles and common PVA microneedles.

[0019] The material for preparing microneedles is polyvinyl alcohol (PVA), and the model drug used is sulforhodamine B. The specific steps are as follows: first, prepare a PVA aqueous solution with a mass percentage of 20 wt% as a microneedle preparation solution; prepare sulforhodamine B with a mass concentration of 1 mg / mL as a model drug solution;

[0020] The steps of the drug loading process are: under vacuum conditions, take the model drug solution and apply it on the microneedle template, after 5 minutes, recover the excess drug solution, and continue to dry in a vacuum environment for 10 minutes;

[0021] The steps for preparing ordinary PVA microneedles are as follows: after the drug loading process is completed, a layer of microneedle preparation solution with a thickness of 2000-3000 μm is coated on the surface of the microneedle template, and vacuum filling takes 45 minutes; the microneedle b...

Embodiment 2

[0026] Bubble-type microneedles with different volume bubble structures were prepared.

[0027] The preparation liquid used for preparing the microneedles is a PVA aqueous solution with a mass percentage of 10-30 wt%, and the viscosity of each group of PVA solutions is measured, and the model drug used is sulforhodamine B. Specific steps are as follows:

[0028]Preparation concentration is 10wt%, 15wt%, 20wt%, 25wt%, the PVA aqueous solution of 30wt% is used as microneedle preparation liquid; Preparation mass concentration is sulfonyl rhodamine B of 1mg / mL as model drug solution; Microneedle preparation basic procedure and Similar to Example 1, different concentrations of PVA solutions were selected when coating the thin layer of microneedle preparation solution, and other conditions were the same. Finally, the microneedles were released from the mold to obtain bubble-type microneedles with different volume bubble structures. Similarly, corresponding ordinary microneedles we...

Embodiment 3

[0033] Preparation of sodium hyaluronate (HA) air bubble microneedles loaded with hepatitis B vaccine:

[0034] The material for preparing the microneedle is sodium hyaluronate, the drug used is hepatitis B vaccine, and the stabilizer used is sucrose. Concrete preparation steps are as follows:

[0035] First, prepare a microneedle preparation solution containing 15wt% HA and 10wt% sucrose; prepare a hepatitis B vaccine solution with a mass concentration of 2 mg / mL;

[0036] The steps of preparing the microneedle with HA bubble structure loaded with hepatitis B vaccine are as follows: under vacuum condition, take the vaccine solution and apply it on the template containing 10×10 microneedle array, after 5 minutes, recover the excess vaccine solution, continue to vacuum Dry for 10 minutes; apply a layer of microneedle preparation solution with a thickness of 100 μm on the surface of the microneedle template, and vacuum fill it for 30 minutes; after the microneedle body and its ...

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Abstract

The invention belongs to the technical field of dosing equipment, and relates to a bubble-type microneedle and a preparation method therefor. The microneedle comprises a microneedle substrate, a drug-carrying microneedle body arranged on the microneedle substrate, and a paster bonded with the microneedle substrate. The drug-carrying microneedle body is conical or shaped like a cone, wherein the height of the drug-carrying microneedle body is from 100 microns to 1000 microns, the bottom diameter is from 50 microns to 1000 microns and the interior of the drug-carrying microneedle body comprises a bubble structure. Drug is gathered at the tip or upper part of the drug-carrying microneedle body. Compared with the prior art, the microneedle is advantageous in that the special bubble-type structure enables the drug to be gathered at the upper end of the needle body and not to diffuse downwards, and improves the load carrying efficiency; the bubble-type structure enables the actual lateral thickness of the lower end of the needle body to be reduced, thereby shortening the subcutaneous dissolution time, and facilitating the dosing for different objects; the source of the raw material of the microneedle is extensive, the consumption of the raw material is small, and the raw material is saved; the prepared microneedle is uniform in structure, and the size of the microneedle can be controlled; the preparation method is simple and feasible, is easy to operate, and can achieve the industrialization.

Description

technical field [0001] The invention belongs to the technical field of drug delivery equipment, and in particular relates to an air-bubble microneedle and a preparation method thereof. Background technique [0002] Transdermal drug delivery is a way to eliminate the pain caused by injection. The use of microneedle technology for transdermal drug delivery can overcome some problems of ordinary transdermal drug delivery, such as being hindered by the stratum corneum and epidermis of the skin, it is difficult to achieve efficient and precise drug delivery. Research on the application of microneedle technology to the percutaneous injection of drugs or vaccines has begun as early as the 1990s. The basic principle of the application of microneedles in drug delivery is that microneedles with micron-scale dimensions can pierce the stratum corneum, but do not touch blood vessels and nerves in the dermis, so that microneedles can be used without causing pain and bleeding. Microchann...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0046A61M2037/0053
Inventor 郭新东王淇磊
Owner BEIJING UNIV OF CHEM TECH
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