The invention discloses a high-low voltage power transformation cabinet and an electric leakage control system. The high-low voltage power transformation cabinet comprises a cabinet body, a cabinet door is hinged to one side of the cabinet body, a lock cylinder is installed on one side of the cabinet door, a sliding rail is fixedly connected to the side, close to the lock cylinder, of the cabinetdoor, and a first sliding plate is connected to the outer side wall of the sliding rail in a sliding mode; the cabinet door can be normally opened only by sliding a circular blocking piece upwards, meanwhile, when the temperature in the cabinet body is too high, a PLC controls an electromagnetic switch to start a motor, the air circulation rate between the interior of the cabinet body and the outside is increased, the temperature is lowered, and safety is guaranteed. A drying agent convenient to replace is disposed in a hollow transverse plate, the humidity inside the cabinet body can be effectively reduced, the replacement is convenient, the maintenance cost is reduced, when the data inside the cabinet body is abnormal, a worker can monitor the data inside the cabinet body in real time through the electric leakage control system, the worker can maintain the cabinet body at the first time, and meanwhile, a buzzer and an alarm can warn surrounding personnel to prevent the personnel frommistakenly touching the cabinet body.