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Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof

A technology of alcoholic liver injury and protective effect, applied in the field of health food, to achieve the effects of simple and feasible preparation process, controllable quality, and scientific and reasonable formula design

Inactive Publication Date: 2014-12-03
BEIJING ZHONGTAI TIANHE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no ideal drug to effectively prevent and treat the occurrence and development of liver diseases in clinical practice.

Method used

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  • Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof
  • Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof
  • Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Formula: Pueraria root extract 115g, Hovenia dulcis fruit extract 45g, Salvia miltiorrhiza extract 70g, turmeric extract 37.5g, ammonium glycyrrhizinate 15g, microcrystalline cellulose 56g, magnesium stearate (additional) 1.5g.

[0035] Preparation:

[0036] 1. The raw and auxiliary materials in the formula are all passed through an 80-mesh sieve and set aside. The production water is purified water, which should meet the requirements of "Chinese Pharmacopoeia" 2010 version of purified water; the ethanol used in production is edible grade ethanol, which should meet the requirements of GB 10343-2008 edible alcohol.

[0037] 2. Accurately weigh Pueraria root extract, Hovenia dulcis fruit extract, Salvia miltiorrhiza extract, turmeric extract, ammonium glycyrrhizinate, and microcrystalline cellulose according to the dosage of the formula, mix them in a mixer, and then add an appropriate amount of ethanol solution to make soft The material is granulated with a swing granul...

Embodiment 2

[0043] Formula: Pueraria root extract 172.5g, Hovenia dulcis fruit extract 22.5g, Salvia miltiorrhiza extract 62g, turmeric extract 18g, ammonium glycyrrhizinate 7.5g, microcrystalline cellulose 185g, crospovidone 30g, magnesium stearate 2.5g g, film coating premix 15g.

[0044] Preparation method: mix the raw and auxiliary materials evenly, sieve, compress into tablets, make tablets, pack and inspect to get standard products.

Embodiment 3

[0046] Formula: 57.5g of kudzu root extract, 67.5g of Hovenia dulcis fruit extract, 105g of salvia miltiorrhiza extract, 30g of turmeric extract, 22.5g of ammonium glycyrrhizinate, and 217.5g of dextrin.

[0047] Preparation method: Mix raw and auxiliary materials evenly, sieve, granulate to make granules, and pack and inspect to obtain standard products.

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Abstract

The invention discloses a composition with an auxiliary protection effect on an alcoholic liver injury and a preparation method of the composition. The composition with the auxiliary protective effect on the alcoholic liver injury is mainly prepared from the following raw materials in parts by weight: 57.5-172.5 parts of kudzuvine root extract, 22.5-67.5 parts of semen hoveniae extract, 35-105 parts of salvia miltiorrhiza extract, 18-57 parts of turmeric extract and 7.5-22.5 parts of ammonium glycyrrhetate. The raw materials respectively have anti-lipid peroxidation effect and protective effect on the liver. Functional tests show that the composition with the auxiliary protection effect on the alcoholic liver injury has better liver protection effect compared with the same dose of single kudzuvine root extract preparation and single semen hoveniae extract preparation, and liver fatty degeneration and liver lipid peroxidation which are caused by the alcoholic liver injury can be obviously alleviated. The composition with the auxiliary protection effect is prepared by adopting a scientific and reasonable production process, is definite in functions, controllable in quality and safe to take and is applicable to a large group of people suffering from the alcoholic liver injury.

Description

technical field [0001] The invention relates to a composition with auxiliary protective effect on alcoholic liver injury and a preparation method thereof, belonging to the technical field of health food. Background technique [0002] Alcoholic liver disease (ALD) is a toxic liver disease caused by long-term excessive drinking, and ALD is the most common cause of liver cirrhosis in Western countries. In my country, alcoholic liver disease has gradually increased in recent years, and has become the second largest cause of liver disease after viral hepatitis. [0003] Alcoholic liver disease is a liver disease caused by long-term heavy drinking. It usually manifests as fatty liver at the initial stage, and then can develop into alcoholic hepatitis, alcoholic liver fibrosis and alcoholic cirrhosis. Severe alcoholism can induce extensive liver cell necrosis or even Liver failure. Up to now, there is no ideal medicine to effectively prevent and treat the occurrence and developme...

Claims

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Application Information

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IPC IPC(8): A23L1/29A61K36/9066A61P1/16A61P39/00A61K31/704A23L33/00
CPCA23L33/105A23V2002/00A61K36/9066A23V2200/30A23V2200/334A23V2250/21
Inventor 何俊保
Owner BEIJING ZHONGTAI TIANHE SCI & TECH
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