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Application of nicotinamide riboside in preparing drugs for treating non-alcoholic steatohepatitis

A technology of steatohepatitis and nicotinamide riboside, which is applied in the field of application of nicotinamide riboside in the preparation of drugs for the treatment of nonalcoholic steatohepatitis, can solve the problems such as the unreported effect of nicotinamide nucleic acid, and help prevent and treat prognostic effect

Inactive Publication Date: 2015-05-20
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology

[0006] However, there is no report on the role of nicotinamide nucleic acid in the treatment of non-alcoholic steatohepatitis.

Method used

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Experimental program
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Embodiment 1

[0018] 1. Method

[0019] Animals were male C57BL / 6 mice at the age of 8 weeks, adopted a high-fat diet (Beijing Weitong Lihua Animal Company, commercially available) with an energy ratio of 60%, and continued for 3 months to induce non-alcoholic steatohepatitis . After 2 months, the liver slices were taken, and the following tests were performed to confirm the successful preparation of nonalcoholic steatohepatitis: (1) oil red O staining proved that a large amount of lipid was deposited in the liver tissue; (2) immunohistochemical staining showed There are a large number of F4 / 80 positive cells in the liver (more than 20 per field of view under the 10x objective lens), that is, activated Kupffer cells (macrophages infiltrating the liver); (3) Real-time PCR detection shows tumors in the liver The expression of necrosis factor (TNF-α) was significantly increased (more than 3 times compared with normal diet animals). The results proved that the model was prepared successfully....

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Abstract

The invention relates to an application of nicotinamide riboside in preparing drugs for treating non-alcoholic steatohepatitis. According to the application, a non-alcoholic steatohepatitis animal model is adopted to prove that the nicotinamide riboside is capable of reducing the liver lipid content, the liver inflammations and the liver fibrosis degree of the animal model and prompt that the nicotinamide riboside can be applied to preparing the drugs for treating the non-alcoholic steatohepatitis. The application of the nicotinamide riboside is expanded, a new way is provided for treating the non-alcoholic steatohepatitis, and therefore, the non-alcoholic steatohepatitis can be prevented and prognosed favorably.

Description

technical field [0001] The present invention relates to a new application of nicotinamide riboside, in particular to the application of nicotinamide riboside in the preparation of medicine for treating non-alcoholic steatohepatitis. Background technique [0002] The English name of nicotinamide riboside is nicotinamide riboside, CAS number 1341-23-7, molecular formula C 11 h 16 N 2 o 5 . [0003] Non-alcoholic steatohepatitis (NASH) is a type of non-alcoholic fatty liver disease (NAFLD), except that it can occur in middle-aged, obese, insulin-resistant diabetes, hyperlipidemia and women, It can also be seen in many other conditions (exposure to drugs, abnormal iron deposition, mutations in the HEF gene, males, and children aged 10 to 15 years). Recently, it has been reported that the rate of liver cirrhosis has reached 16%, and the recurrence of NASH after liver transplantation has also been reported. [0004] Common lesions of NASH include fat deposition, lobular infl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P1/16
Inventor 缪朝玉王培杨茜徐添颖李志勇
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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