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297results about How to "Increase gene expression" patented technology
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Antibodies and methods for generating genetically altered antibodies with enhanced effector function
InactiveUS20050054048A1Increase variabilityBetter pharmacokinetic profileAnimal cellsSugar derivativesGenetic diversityMonoclonal antibody
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the effector function of monoclonal antibodies and monoclonal antibodies with increased effector function.
Owner:EISAI INC
External addition of pulses to fluid channels of body to release or suppress endothelial mediators and to determine effectiveness of such intervention
InactiveUS7090648B2Easy to adjustHigh expressionElectrotherapyPneumatic massageShear stressReciprocating motion
Methods of medical treatment and diagnosis using mediators released by endothelial cells stimulated by external addition of pulses to the circulation are disclosed. The external pulses produce circumferential shear stress in body fluid channels that subsequently stimulates the endothelial cells to produce mediators that become available for therapeutic and diagnostic purposes. The preferred means of adding external pulses is the mechanical inducement of periodic acceleration of the body or parts of the body by a reciprocating motion platform.
Owner:NON INVASIVE MONITORING SYST INC
Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
ActiveUS20060088919A1Improve productivityD-xylose permease is enhancedBacteriaDepsipeptidesL-threonineArginine
There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
Owner:AJINOMOTO CO INC
System for increasing gene expression and vector comprising the system
ActiveUS20120309050A1Increase gene expressionEnhance protein expressionFungiVirusesDNA constructCancer research
An object of the present invention is to provide a method for increasing the expression of foreign genes, in particular, using a promoter, an enhancer, and the like, and an expression cassette containing a promoter, an enhancer, and the like, by which gene expression can be increased. The purpose is achieved with the use of the gene expression cassette comprising a DNA construct containing a gene to be expressed and a poly A addition sequence that are located downstream of a 1st promoter, and further comprising an enhancer or a 2nd promoter ligated downstream of the DNA construct.
Owner:UNIV OKAYAMA +1
Methods and compositions for treating metabolic disorders
InactiveUS20090143279A1Cell viability decreaseIncrease gene expressionBiocideNervous disorderOxidative phosphorylationDisease
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE
Small Activating RNA Molecules and Methods of Use
ActiveUS20100210707A1Increase gene expressionOrganic active ingredientsSenses disorderMolecular biologyNucleic acid sequencing
The present invention provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a non-coding nucleic acid sequence of the gene.
Owner:RGT UNIV OF CALIFORNIA +1
Differentiation modulating agents and uses therefor
InactiveUS20120059047A1Reduce expressionIncrease gene expressionOrganic active ingredientsPeptide/protein ingredientsSignalling pathwaysObesity
The present invention is directed to methods and agents for modulating the differentiation potential and / or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (FGF) signaling pathway, especially the FGF-1 or FGF-2 signaling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.
Owner:VERVA PHARMA
Substance delivery via a rotating microabrading surface
ActiveUS7166086B2Increase gene expressionEnhance immune responseSurgical needlesMicroneedlesPhysical therapyDermatomal
A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a substance to an area of a patient's skin through the rotational movement of microprotrusions which may be imparted by a spring device present in the microabrader device or the motion of the operator through the handle of the microabrader device. The device may further include system and methods for monitoring pressure of the device against the skin and thereby promote consistency between applications and control of penetration depth. The delivered substance may be placed on the microprotrusions and a reconstituting liquid included in the microabrader device.
Owner:BECTON DICKINSON & CO
Triblock copolymers for cytoplasmic delivery of gene-based drugs
ActiveUS20100222407A1Reduction in expression of target geneIncrease gene expressionAnimal cellsGenetic material ingredientsDiseaseCrystallography
The invention features a triblock copolymer including a hydrophilic block; a hydrophobic block; and a positively charged block capable of reversibly complexing a negatively charged molecule, e.g., a nucleic acid, wherein the hydrophobic block is disposed between the hydrophilic block and the positively charged block. Desirably, the triblock copolymer is capable of self-assembling into a supramolecular structure, such as a micelle or vesicle. The invention further features methods of delivering negatively charged molecules and methods of treating a disease or condition using the polymers of the invention.
Owner:ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
Method and device for the delivery of a substance including a covering
ActiveUS7316665B2Increase gene expressionEnhance immune responseSurgeryMicroneedlesBiomedical engineeringBioactive substance
Owner:BECTON DICKINSON & CO
High expression Zymomonas promoters
Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.
Owner:ALLIANCE FOR SUSTAINABLE ENERGY +1
L-tyrosine-producing bacterium and a method for producing L-tyrosine
ActiveUS20050277179A1Reduced gene expressionEfficient productionBacteriaOxidoreductasesTyrosineMicrobiology
The present invention describes the production of L-tyrosine by culturing in a medium an Escherichia bacterium which has L-tyrosine-producing ability and which carries a mutant prephenate dehydrogenase which is desensitized to feedback inhibition by L-tyrosine, producing and accumulating L-tyrosine in the medium or in the bacterial cells, and collecting L-tyrosine from the medium or the bacterial cells.
Owner:AJINOMOTO CO INC
Biocatalytic oxidation process with alkl gene product
ActiveUS20130052700A1Increase synthesisHigh expressionBacteriaUnicellular algaeSimple Organic CompoundsMicroorganism
The invention provides a biocatalytic process for oxidation of organic compounds with the aid of an alkL gene product, and microorganisms used in this process.
Owner:EVONIK OPERATIONS GMBH
Method and device for the delivery of a substance including a covering
ActiveUS20060047242A1Increase gene expressionEnhance immune responseSurgeryMicroneedlesBiomedical engineeringBioactive substance
Owner:BECTON DICKINSON & CO
Control of post-transcriptional gene silencing in plants
InactiveUS6972349B1Suppress gene expressionEnhance gene silencingStable introduction of DNAPlant peptidesCalmodulinGene expression
Owner:SOUTH CAROLINA UNIV OF
Therapeutic targets for mitochondrial disorders
InactiveUS20150065556A1Decreased functional expression of geneIncreasing and decreasing gene expressionCompound screeningApoptosis detectionDiseaseMitophagy
In some aspects, compositions and methods for identifying therapeutic targets for treatment of mitochondrial disorders are provided. In some aspects compositions and methods for identifying therapeutic agents for treatment of mitochondrial disorders. In some aspects, the disclosure identifies ATPIF1 as a therapeutic target for mitochondrial disorders.
Owner:WHITEHEAD INST FOR BIOMEDICAL RES
Differentiation modulating agents and uses therefor
InactiveUS20050282733A1Reduced gene expressionIncrease gene expressionBiocidePeptide/protein ingredientsPre adipocytesObesity
The present invention is directed to methods and agents for modulating the differentiation potential and / or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (FGF) signaling pathway, especially the FGF-1 or FGF-2 signaling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.
Owner:ADIPOGEN PTY LTD +1
Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses
InactiveUS20140271550A1Increase gene expressionLower immune responseBiocideSugar derivativesNucleotideGene product
A CpG-modified recombinant adeno-associated viral (AAV) vector is described. The vector carries a nucleic acid molecule comprising AAV inverted terminal repeat (ITR) sequences and an exogenous gene sequence under the control of regulatory sequences which control expression of the gene product, in which the nucleic acid sequences carried by the vector are modified to significantly reduce CpG di-nucleotides such that an immune response to the vector is reduced as compared to the unmodified AAV vector. Also provided are methods and regimens for delivering transgenes using these AAV viral vectors, in which the innate immune response to the vector and / or transgene is significantly modulated.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA +2
Optimization of transgene expression in mammalian cells
InactiveUS20060051331A1Increase capacityIncrease transgene expressionSenses disorderFungiTransgeneMammalian cell
The present invention relates to vectors, compositions and methods for delivering transgenes into mammalian cells. The invention also relates to genetic constructs and recombinant cells suitable to produce such transgenes. The invention more particularly relates to a vector suitable for transgene delivery into mammalian cells, wherein said vector comprises a chimeric genetic construct comprising a transgene operably linked to at least two distinct posttranscriptional regulatory elements functional in mammalian cells. This invention can be used in experimental, research, therapeutic, prophylactic or diagnostic areas.
Owner:CENT NAT DE LA RECHERCHE SCI +1
Topical delivery of vaccines
InactiveUS20080009785A1Increase gene expressionEnhance immune responsePowder deliverySnake antigen ingredientsMedicinePeptide
The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.
Owner:BECTON DICKINSON & CO
Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
InactiveUS20070042937A1Increase gene expressionInhibit hydroxylationBiocidePeptide/protein ingredientsDiseaseThalassemia
The present invention provides methods for increasing endogenous globin expression in a subject, specifically γ-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., β thalassemia and sickle cell disease.
Owner:ISIS INNOVATION LTD +1
Vectors for Liver-Directed Gene Therapy of Hemophilia and Methods and Use Thereof
ActiveUS20150283267A1Improve efficiencyImprove securityVectorsPeptide/protein ingredientsFactor iiFhit gene
The present invention relates to vectors containing liver-specific regulatory sequences and codon-optimized factor IX or factor VIII genes, methods employing these vectors and uses of these vectors. Expression cassettes and vectors containing these liver-specific regulatory elements and codon-optimized factor IX or factor VIII genes are also disclosed. The present invention is particularly useful for applications using gene therapy, in particular for the treatment of hemophilia A and B.
Owner:VRIJE UNIV BRUSSEL
Recombinant polypeptide useful for neurotrophin receptor mediated gene delivery and as neurotrophin agonist
InactiveUS20050048606A1High resolutionNon invasivePeptide/protein ingredientsImmunoglobulins against cell receptors/antigens/surface-determinantsGene deliveryNeurotrophin Receptor p75
The invention provides a novel recombinant polypeptide that comprises a nucleic acid binding element and a hairpin motif that selectively binds to a neurotrophin receptor. The recombinant polypeptide may be used for neurotrophin receptor mediated delivery of nucleic acid, including therapeutic DNA, bound to the recombinant polypeptide. In one embodiment, the hairpin motif is a hairpin motif of a neurotrophin, such as nerve growth factor, brain derived neurotrophic factor, neurotrophin 3 and neurotrophin 4 / 5. The hairpin motif is also a neurotrophin agonist and therefore may be used to treat any disorder responsive to neurotrophin treatment, such as neurological disorders and tumour. In one embodiment the agonist comprises a hairpin motif that selectively binds to a neurotrophin receptor and a positively charged binding domain which is believed to enhance receptor binding by binding to negatively charged cell membrane.
Owner:AGENCY FOR SCI TECH & RES
Enhancing protein expression
InactiveUS20090069256A1Increase gene expressionHigh expressionOrganic active ingredientsMicroorganismsDiseasePolynucleotide
Modified polynucleotide compositions providing enhanced gene expression and methods for preparing said compositions are disclosed. Methods of using the compositions, such as in screening assays, diagnostic tools, kits, etc. and for prevention and / or treatment of diseases and disorders are also disclosed.
Owner:WYETH LLC
METHOD OF INHIBITING NONSENSE-MEDIATED mRNA DECAY
ActiveUS20110039911A1Prevent intracellular hypusination of eIF5AIncrease gene expressionBiocideNervous disorderMRNA DecayCancer research
Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.
Owner:RUTGERS THE STATE UNIV
Global Gene Expression Analysis of Human Bronchial Epithelial Cells Exposed to Cigarette Smoke, Smoke Condensates, or Components Thereof
InactiveUS20080052789A1Reduced potential to contributeReduced expression levelSugar derivativesMicrobiological testing/measurementNicotiana tabacumBiomarker (petroleum)
Aspects of the present invention concern the identification of several methods to analyze the genes that are modulated in normal human bronchial epithelial (NHBE) cells after exposure to cigarette smoke condensates (CSC) or cigarette smoke (CS). Embodiments described herein include methods to identify a gene that is modulated in response to exposure to CSC or CS, methods to identify tobacco products that have a reduced potential to contribute to tobacco-related disease, methods to make tobacco products that have a reduced potential to contribute to a tobacco-related disease, methods to identify a subject's predilection to acquire a tobacco related disease, the use of particular genes as biomarkers for tobacco-related disease, and patterns of gene expression or genetic signatures that are unique to each particular tobacco product.
Owner:VECTOR TOBACCO LLC
Purine-derived substance-producing bacterium and a method for producing purine-derived substance
InactiveUS7326546B2Reduced activityIncrease enzyme activitySugar derivativesBacteriaBacteroidesPurine
Owner:AJINOMOTO CO INC
Use of ace inhibitors and/or angiostensin ii receptor antagonists for the improving and/or maintaining the skin tone and for the treatment of skin ageing
InactiveUS20090143458A1Reduced gene expressionIncrease gene expressionCosmetic preparationsBiocideNK1 receptor antagonistDepressant
The present invention relates to use of an ACE inhibitor and / or angiotensin II receptor antagonist of the preparation of a medicament for the treatment of skin ageing or wrinkling. Furthermore, the present invention relates to use of an ACE inhibitor and / or angiotensin II receptor antagonist for the preparation of a cosmetic composition.
Owner:ACE APS
Intramyocardial injection of autologous bone marrow
InactiveUS20040161421A1Enhance therapeutic myocardial angiogenesisGood effectBiocidePeptide/protein ingredientsAngiogenesis growth factorCardiac muscle
A method of treating cardiac or myocardial conditions comprises the administration of an effective amount of autologous bone marrow. The bone marrow may optionally be stimulated and / or administered in combination with a pharmaceutical drug, protein, gene or other factor or therapy that may enhance bone marrow production of angiogenic growth factors and / or promote endothelial cell proliferation or migration or blood vessel formation.
Owner:KOMOWSKI RAN +3
Promoter gene, recombinant turkey herpesvirus having the novel promoter gene, and poultry vaccine including the recombinant herpes virus of turkey
ActiveUS20080233146A1Increase gene expressionEasy to set upSsRNA viruses negative-senseVectorsTurkey HerpesvirusHerpes simplex virus DNA
Promoter genes that are derived from Marek's disease virus (MDV). These promoter genes can express two foreign genes when inserted in a recombinant turkey herpesvirus (HVT). A recombinant HVT having said novel promoter gene between two foreign genes. The poultry vaccine consisting of the recombinant turkey herpesvirus described in the present invention.
Owner:ZEON CORP
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