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Application of baicalein extract in preparation of medicament for controlling hyperlipidemic fatty liver

A technology of hyperlipidemia and baicalein, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effects of reducing liver weight and liver coefficient, regulating blood lipids, and reducing content

Inactive Publication Date: 2010-06-16
苏州中药研究所有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In view of the fact that baicalein has various pharmacological effects such as antibacterial, anti-inflammatory, hepatoprotective and effective free radical scavengers and xanthine oxidase inhibitors, and there is no application of baicalein to prevent and treat hyperlipidemic fatty liver. Therefore, the inventor has studied whether baicalein has a preventive and therapeutic effect on hyperlipidemic fatty liver rat animal model.

Method used

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  • Application of baicalein extract in preparation of medicament for controlling hyperlipidemic fatty liver
  • Application of baicalein extract in preparation of medicament for controlling hyperlipidemic fatty liver
  • Application of baicalein extract in preparation of medicament for controlling hyperlipidemic fatty liver

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Embodiment

[0039] Embodiment Pharmacodynamic experiment

[0040] 1. Test material

[0041] Experimental animals: SD rats, male, weighing 170-190 g, clean grade, provided by the Experimental Animal Center of Soochow University School of Medicine. Experimental animal production license number: XCYK (Su) 2002-0008, use license number: SYXK (Su) 2007-0035. During the experiment, the temperature of the feeding room was (20±2)°C.

[0042] Drugs and main reagents: baicalein extract: baicalein content ≥ 50%, brownish-yellow crystals, batch number: 090429, extracted from Scutellaria baicalensis root by the phytochemical laboratory of our institute, and stored in a refrigerator at 4°C. Lipingzhi (fenofibrate) capsules, produced by France Liboforni Pharmaceutical Co., Ltd., batch number: 93405, import drug registration certificate number: H20050004, prepared with 0.5% carboxymethylcellulose sodium solution (CMC-Na) before use into 1% drug concentration. Homemade lard; cholesterol, produced by S...

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Abstract

The invention discloses application of a baicalein extract in preparation of a medicament for controlling hyperlipidemic fatty liver. The baicalein extract is proved to have effect of preventing the hyperlipidemic fatty liver in pharmacological experiments, and is particularly used for reducing the liver weight and the liver coefficient of rats and reducing the content of the blood fat and liver lipid.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to the application of a baicalein extract in the preparation of medicines for preventing and treating hyperlipidemic fatty liver. Background technique [0002] Baicalein is one of the active ingredients extracted from the dry root of the perennial herb Scutellaria baicalensis Georgi in the family Labiatae, and its chemical structure belongs to flavonoids. Studies have shown that baicalein has the functions of reducing cerebrovascular resistance, improving cerebral blood circulation, increasing cerebral blood flow and anti-platelet aggregation, and has various pharmacological effects such as antibacterial, antiviral, anti-inflammatory, hepatoprotective, diuretic, and anticancer. In addition, baicalein is also an effective free radical scavenger and xanthine oxidase inhibitor for the prevention and treatment of cardiovascular diseases. [0003] Fatty liver (F...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K31/352A61P3/06A61P1/16
Inventor 顾振纶蒋小岗彭蕾郭次仪
Owner 苏州中药研究所有限公司
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