The invention belongs to the field of traditional Chinese medicines, and particularly discloses application of an
angelica sinensis-
astragalus membranaceus blood-activating preparation in preparation of a
medicine for preventing or treating diabetic complications. The
angelica sinensis-
astragalus membranaceus blood-activating preparation is prepared from thirteen raw medicinal materials including
astragalus membranaceus,
angelica sinensis, radix paeoniae alba, radix polygoni multiflori preparata, fructus lycii, mistletoe,
cornu cervi pantotrichum, rhizoma drynariae, radix clematidis, garden
balsam stem, musk, radix puerariae and
ligusticum wallichii, and has the effects of tonifying qi and
kidney and promoting
blood circulation to remove meridian obstruction. Pharmacodynamic tests show that the angelica sinensis-astragalus membranaceus blood activating preparation can effectively accelerate the ischial
nerve conduction speed of diabetic
peripheral neuropathy model rats, remarkably reduce the serum MDA level of the rats, improve the
activity level of SOD and GSH-Px, improve the free radical
scavenging capacity of the organisms and enhance the
oxidation resistance of the organisms and tissues, so that the rat ischial
nerve injury is protected and repaired, the
traditional Chinese medicine composition has an exact
treatment effect on diabetic
peripheral neuropathy, is comprehensive in effect and low in toxic and side effects, and has a wide market prospect.