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64 results about "Dimethyl Sulphone" patented technology

Dimethyl Sulfone is an organosulfur compound (or to put it simply, an organic sulfur) that comes in the form of many names like methylsulfonylmethane (MSM), DMSO2, and methyl sulfone among others. This chemical can be found in leafy green veggies, radishes, garlic, onions, and chives.

Preparation method for synthesizing apremilast intermediate

The invention relates to a preparation method for synthesizing an apremilast intermediate. The preparation method comprises the following steps of: carrying out condensation reaction on 3-ethoxyl-4-methoxyl-benzoate and dimethyl sulfone under an alkaline condition to generate 2-(3-ethoxy-4-methoxyphenyl)-1-methylsulfonyl acetone; reacting the compound II and chiral amine in the presence of an acidic catalyst to obtain 1-N-substituted amino-1-(3-ethoxyl-4-methoxyl) phenyl-2-methylsulfonyl ethylene (III), and directly hydrogenating the obtained compound III in the presence of a hydrogenation catalyst without separating the compound III to obtain a product (S)-1-(3-ethoxyl-4-methoxyl) phenyl-2-methanesulfonyl ethylamine (I), namely the apremilast intermediate, wherein the apremilast intermediate can be further prepared into N-acetyl L-leucinate. The invention also provides a preparation method of apremilast. The preparation method disclosed by the invention has the advantages of simple process flow, safety, environmental friendliness and low cost and is favorable to clean industrialized production.
Owner:XINFA PHARMA

Preparation method for dimethyl sulfone

The invention provides a preparation method for dimethyl sulfone. The method comprises the step of subjecting a liquid mixture to passing through a catalyst bed filled with at least one titanium-silicon molecular sieve in a fixed bed reactor under the condition of oxidation reaction so as to obtain a mixture containing dimethyl sulfone, wherein the liquid mixture comprises dimethyl sulfide and at least one peroxide; and the mol ratio of the peroxide to the dimethyl sulfide is more than 2: 1. According to the invention, with peroxide as an oxidant, the method has low corrosiveness to equipment, releases few environmental pollutants, can obtain high conversion rate of dimethyl sulfide and selectivity of dimethyl sulfone, and has high effective utilization rate of the oxidant at the same time.
Owner:CHINA PETROLEUM & CHEM CORP +1

Method for separating phenol, arene and alkane in direct coal liquefaction effluent through one-step method

The invention relates to a method for separating phenol, arene and alkane in direct coal liquefaction effluent through a one-step method. The method comprises the steps that dimethyl sulfoxide or mixed solvent of dimethyl sulfone and sulfolane is selected as extracting solvent (solvent A for short), and the direct coal liquefaction effluent is directly divided into phenol, arene and alkane through an extraction and rectification means. Obtained cycloparaffin can be directly taken as fuel, the obtained arene can be taken as a chemical material, and a mixture of a phenolic compound and the solvent A which are retained at the kettle bottom can be subjected to water-organic solvent (solvent B for short) extraction to obtain the phenol. According to the method, the liquefaction effluent can be directly divided into the three compounds, and the advantages that the product purity is high, the operating technology is simple, the system energy consumption is low, and equipment is not corroded due to the fact that acid and base are not used are achieved; in addition, the solvent A, the solvent B and water which are used in the method can be recycled, therefore, waste liquid discharge is reduced, and environmental protection is facilitated.
Owner:TAIYUAN UNIV OF TECH

Preparation method of dimethyl sulfone as well as used catalyst and catalyst composition thereof

The invention belongs to the field of organic synthetic chemistry, and in particular relates to a preparation method of dimethyl sulfone as well as used catalyst and catalyst composition thereof. The general formula of the catalyst is aFe2O3.bMnO2.cTiO2.dRh203.eRuO2, wherein a, b and c are selected from 0 to 15 independently, and d and e are selected from 0.01 to 10 independently. The catalyst composition comprises the catalyst and photosensitizer with the mass ratio of 1:0.01 to 10. The catalyst / catalyst composition has efficient catalytic activity, oxygen is taken as single oxidant during a process of catalyzing dimethylsulfide or dimethyl sulfoxide to prepare dimethyl sulfone, and compared with a conventional nitric acid technique and a potassium permanganate method, the preparation method has the advantages that during preparation, any hazardous substances can not be caused, and pollution is not caused to the environment.
Owner:GENIFARM LAB INC +1

Dimethyl sulfone preparation method

The invention discloses a dimethyl sulfone preparation method. The dimethyl sulfone preparation method comprises causing dimethyl sulfoxide and at least one oxidizing agent to be in contact with at least one titanium silicate molecular sieve under the conditions of oxidation reaction, wherein the at least part of the titanium silicate molecular sieve is a non-fresh titanium silicate molecular sieve. Compared with a method of causing dimethyl sulfoxide to undergo contact reaction with the oxidizing agent in the absence of catalysts, the dimethyl sulfone preparation method can achieve the obviously improved dimethyl sulfoxide conversion rate, the effective utilization rate of the oxidizing agent and dimethyl sulfone selectivity. Compared with a method of causing dimethyl sulfoxide and the oxidizing agent to undergo contact reaction with a fresh titanium silicate molecular sieve, the dimethyl sulfone preparation method can achieve a higher effective utilization rate of the oxidizing agent, and in the long-cycle continuous reaction process, the conversion rate of dimethyl sulfoxide and the selectivity of dimethyl sulfone are more stable. In addition, the method is moderate in reaction conditions, easy to control and suitable for devices of various production scales.
Owner:CHINA PETROLEUM & CHEM CORP +1

Method for synthesizing 2-acetyl phenothiazine using phenothiazine as raw material

The present invention discloses a method for synthesizing 2-acetyl phenothiazine using phenothiazine as a raw material. The method comprises: by using silicon dioxide as a catalyst, heating phenothiazine with formic acid by microwave radiation for a nucleophilic substitution reaction; conducting an electrophilic substitution reaction on the product obtained in the first step and acetyl chloride under catalysis of aluminium trichloride in a dimethyl sulphone solvent; and conducting a hydrolysis reaction on the product obtained in the second step under catalysis of a strong base. According to the method provided by the invention, phenothiazine is used as the raw material, and through N-formylated nucleophilic substitution, electrophilic substitution on benzene rings and hydrolysis of N-acylamino, 2-acetyl phenothiazine is obtained. According to the method disclosed by the invention, secondary amine is formylated in the method to weaken the positioning effect of N atoms on phenyl rings in ortho-position and para-position of the N atoms, so that the leading role of S atoms on the positioning effect in the ortho-position and the para-position of the S atoms s ensured, and the yield of a target product 2-position acetyl substituted product is significantly improved, thereby ensuring the total yield and purity of 2-acetyl phenothiazine.
Owner:TAICANG YUNTONG BIOCHEM ENG

Composition for pets and application thereof

The invention relates to a composition for pets and an application thereof. The composition for the pets comprises a cannabidiol-containing raw material, dimethyl sulfone, glucosamine sulfate, menthol, thymol, vitamin B2 and active silver ions. The components in the composition for the pets cooperate with one another to achieve a synergistic effect, so that the composition can prevent and treat oral diseases of the pets, protect oral health of the pets and effectively improve various symptoms caused by pet arthritis, and also has the effects of relieving pet dysphoria and anxiety and calming and relieving pet mood. When being used for preparing a pet spray, the composition can be administrated through oral mucosa, and has the advantages of quick effect taking and high bioavailability.
Owner:YUNNAN HEMPMON PHARMA CO LTD

Composition, preparation method thereof and application of composition in preparing joint maintenance medicines, health-care products and food

The embodiments of the present invention disclose a composition, a preparation method thereof and an application of the composition in preparing joint maintenance medicines, health-care products and food. The composition comprises the following materials in parts by mass: 71-169 parts of glucosamine, 60.8-144.8 parts of dimethyl sulfone, 101.4-241.4 parts of perna canaliculus, 2.5-6.0 parts of collagen, 5.1-12.1 parts of bone glue, 71-169 parts of enzymatic bone meal and 71-169 parts of a cartilage extract. The composition starts from three aspects of slowing pains, controlling inflammation and promoting cartilage healing, works together to fundamentally maintain joints, and prevent and repair joint diseases, is free of toxic and side effects, and can be consumed for a long time.
Owner:SHENZHEN REDRAY BIOTECHNOLOGY CORP LTD

Polyethylene microporous membrane as well as preparation method and application thereof

The invention provides a preparation method of a polyethylene microporous membrane. The method comprises the following steps: mixing 20-60wt% of polyethylene and 40-80wt% of a composite diluent to obtain a premix; carrying out melt extrusion and cooling molding on the premix to obtain a primary membrane; and removing the composite diluent in the primary membrane by adopting an extracting agent, and then carrying out heat treatment to obtain a polyethylene microporous membrane. The composite diluent comprises a high-temperature solvent and a non-solvent, the high-temperature solvent is selectedfrom one or more of tetradecanoic acid, hexadecanoic acid, octadecanoic acid, eicosanoic acid, docosanoic acid, tetradecanol, hexadecanol, octadecanol and eicosanol, the non-solvent is selected fromone or more of benzophenone, diphenyl carbonate and dimethyl sulfone, and the high-temperature solvent accounts for no less than 60 wt%. By adopting the specific composite diluent, liquid-liquid phaseseparation can still occur when the polymer concentration is high in the phase separation process, and the obtained polyethylene microporous membrane has excellent air permeability and mechanical strength and is suitable for being used as a lithium battery diaphragm material.
Owner:CHINA PETROLEUM & CHEM CORP +1

Traditional Chinese medicine composition and preparation method and application thereof

The invention provides a traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following components in parts by weight of 5-15 parts of ligusticum wallichii, 5-15 parts of rhizoma gastrodiae, 10-30 parts of kadsura pepper stems, 5-15 parts of radix angelicae pubescentis, 5-15 parts of fresh ginger sheets,5-15 parts of safflowers, 5-15 parts of Pseudo-ginseng, 5-15 parts of radix clematidis, 5-15 parts of erodium stephanianum willd, 5-15 parts of turmeric, 5-15 parts of borneol, 5-15 parts of Tibet snow lotus flowers, 5-15 parts of prepared rehmannia roots, 5-15 parts of radix astragali, 1-3 parts of capsaicine, 5-15 parts of radix angelica sinensis, 0.5-1.5 parts of ginseng, 0.5-1.5 parts of dimethyl sulfone, 2.5-7.5 parts of peppermint essence oil, 1-3 parts of fresh ginger essential oil, 1-3 parts of argy wormwood leaf essential oil and 90-240 parts of Baijiu. The traditional Chinese medicine composition has notable treatment effects of treating and preventing arthritis (particularly rheumatoid arthritis ), psoatic strain and sciatica, can eliminate pain caused by lumbar disc herniation, and can completely heal tendon and bone pain caused by attack by wind. The problems that at current, in the markets, medicines are difficult for effective treatment of symptoms, and are high in toxic and side effects are solved.
Owner:连国强

Preparation method of dimethyl sulfone

The invention discloses a preparation method of dimethyl sulfone. The method includes the step of making dimethyl sulfoxide make contact with at least one oxidant and at least one titanium silicalite molecular sieve serving as the catalyst in a reaction area of a reactor under the oxidation reaction conditions, wherein in the contact process, the titanium silicalite molecular sieves move in the reaction area in the axial direction of the reactor. According to the method, the problem that temperature runaway of a catalytic bed probably happens to a fixed bed reactor can be effectively solved, the high dimethyl sulfoxide conversion rate, oxidant effective utilization rate and dimethyl sulfone selectivity can be achieved, and the service life of the catalyst can be prolonged; meanwhile, without shutting down equipment, the titanium silicalite molecular sieves of which the activity does not meet the requirement can be removed out of a reactor system for regeneration.
Owner:CHINA PETROLEUM & CHEM CORP +1

A kind of compound spray film agent for dairy cows and preparation method thereof

The invention belongs to the technical field of veterinary drug preparations, and discloses a compound spray film agent for cows, which is made of the following components in parts by weight: 1-5 parts of povidone-iodine, 0.1-2 parts of clove oil, two 2-8 parts of methyl sulfone, 3-10 parts of film-forming agent, 0.5-2 parts of thickener, 0.5-2 parts of humectant, 0.5-2.5 parts of transdermal absorption accelerator, 70-90 parts of solvent; the solvent It is a mixture of alcoholic solvents and aqueous solvents. The compound spray film agent of the present invention uses povidone iodine, clove oil, borneol / menthol, and dimethyl sulfone as the composite components of the principal agent, and dimethyl sulfone is applied to the film spray agent for cow mastitis for the first time to improve poly Povidone iodine and clove essential oil’s antibacterial and disinfection ability can promote the healing of dairy cow udder wounds, and solve the problem that traditional spraying agents only use povidone iodine single preparation and can only prevent dairy cow mastitis but cannot treat it; compared with other dairy cow mastitis The preparation for external use is evenly coated, the film-forming speed is fast, there is no sagging or dripping phenomenon, the effect of promoting wound healing is obvious, and the healing rate is high.
Owner:ZHENGZHOU BARY ANIMAL PHARMA

Non-aqueous electrolyte secondary battery

A non-aqueous electrolyte secondary battery having a positive electrode, a separator, a negative electrode opposed to the positive electrode via the separator, and a liquid electrolyte wherein the liquid electrolyte includes a lithium salt, methyl acetate, and dimethyl sulfone. The content ratio of methyl acetate in the liquid electrolyte is 10% by mass to 40% by mass, and the content ratio of dimethyl sulfone in the liquid electrolyte is 0.1% by mass to 5% by mass.
Owner:PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO LTD

Novel method for synthesizing isotopic hydroxyl and methylsulfonyl methyl compound

The invention provides a novel method for synthesizing an isotopic hydroxyl and methylsulfonyl methyl compound. The method comprises the following steps: carrying out low-temperature lithiation reaction on a keto-carbonyl raw material compound and dimethyl sulfone, and carrying out one-step synthesis to obtain an isotopic hydroxyl and methylsulfonyl methyl series compound in situ on keto-carbonyl.According to the novel preparation method of the isotopic hydroxyl and methylsulfonyl methyl compound, the whole synthesis route is short in step, good in repeatability, wide in application substrate, high in yield, mild in operation condition and high in safety, and large-scale production and industrial popularization and application are facilitated.
Owner:CHENGDU CHEMPARTNER

Process for producing dimethyl sulfone by double-column rectification

The invention provides a device for producing dimethyl sulfone by double-tower rectification. The feed pipe is connected to the middle part of the mother rectification tower, the bottom of the mother rectification tower is connected to the reboiler, the reboiler is connected to the bottom of the sub-rectification tower, and the sub-rectification tower is connected to the bottom of the sub-rectification tower. The top of the distillation tower is connected to the atomized crystallizer, the atomized crystallizer is connected to the first storage tank, the atomized crystallizer and the bottom of the storage tank are respectively connected to the product area through pipelines, and connected to the upper part of the sub-distillation tower. The process includes opening the reboiler, evacuating the mother rectification tower and the sub-distillation tower, feeding the fraction to be separated into the mother rectification tower through the feed port, and extracting a large amount of dimethyl sulfone from the top of the sub-rectification tower. The top fraction of the sub-distillation tower is granulated and screened by an atomization crystallizer to obtain dimethyl sulfone product. In this process scheme, the mode of rectification and separation under vacuum state breaks the traditional long-term low-temperature crystallization and centrifugal separation mode, and greatly improves the purity and quality level of the product; the selected rectification equipment is double-tower rectification, which is shared by both towers Reboiler saves energy consumption.
Owner:新疆兴发化工有限公司
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