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239 results about "Formic Acid Esters" patented technology

Formate (IUPAC name: methanoate) is the anion derived from formic acid. Its formula is represented in various equivalent ways: CHOO− or HCOO− or HCO2−. It is the product of deprotonation of formic acid. It is the simplest carboxylate anion. A formate (compound) is a salt or ester of formic acid.

Preparation method for synthesizing apremilast intermediate

The invention relates to a preparation method for synthesizing an apremilast intermediate. The preparation method comprises the following steps of: carrying out condensation reaction on 3-ethoxyl-4-methoxyl-benzoate and dimethyl sulfone under an alkaline condition to generate 2-(3-ethoxy-4-methoxyphenyl)-1-methylsulfonyl acetone; reacting the compound II and chiral amine in the presence of an acidic catalyst to obtain 1-N-substituted amino-1-(3-ethoxyl-4-methoxyl) phenyl-2-methylsulfonyl ethylene (III), and directly hydrogenating the obtained compound III in the presence of a hydrogenation catalyst without separating the compound III to obtain a product (S)-1-(3-ethoxyl-4-methoxyl) phenyl-2-methanesulfonyl ethylamine (I), namely the apremilast intermediate, wherein the apremilast intermediate can be further prepared into N-acetyl L-leucinate. The invention also provides a preparation method of apremilast. The preparation method disclosed by the invention has the advantages of simple process flow, safety, environmental friendliness and low cost and is favorable to clean industrialized production.
Owner:XINFA PHARMA

Method of Preparing Cyclic Carbonates, Cyclic Carbamates, Cyclic Ureas, Cyclic Thiocarbonates, Cyclic Thiocarbamates, and Cyclic Dithiocarbonates

A method of preparing a cyclic monomer, comprising: forming a first mixture comprising a precursor compound, bis(pentafluorophenyl) carbonate, and a catalyst; wherein the precursor compound has a structure comprising a) two or more carbons, and b) two functional groups selected from the group consisting of primary amine, secondary amine, thiol group, hydroxyl group, and combinations thereof; and agitating the first mixture at a temperature effective to form a second mixture comprising the cyclic monomer, the cyclic monomer selected from the group consisting of a cyclic carbonate, a cyclic carbamate, a cyclic urea, a cyclic thiocarbonate, a cyclic thiocarbamate, and a cyclic dithiocarbonate.
Owner:IBM CORP

Method for synthesizing formic ester and specific catalyzer thereof

The present invention discloses nanometer metal catalyst catalyzed formic acid ester synthesizing process, in which alcohol is catalyzed for caronylation reaction in the presence of nanometer metal catalyst and CO. The nanometer metal catalyst with particle size of 1-10 nm is prepared through mixing metal salt and macromolecular stabilizer, dispersing in liquid medium and reducing with reductant. The nanometer metal catalyst has the following advantages: capacity of realizing 3D free rotation, excellent low temperature activity capable of catalyzing formic acid ester synthesis at 60-200 deg.c, high conversion efficiency and high selectivity of formic acid ester, stable performance, environment friendship, etc. The nanometer metal catalyst catalyzed formic acid ester synthesizing process of the present invention has broad application foreground.
Owner:PEKING UNIV

Wetting and dispersing agent, production method and use thereof

The invention relates to a wetting and dispersing agent that can be produced by carrying out step (1): wherein a) an organic polymer containing primary and / or secondary amino groups and h) at least one branched polyhydroxymonocarboxylic acid comprising, in addition to a carboxyl group, at least two hydroxy groups, one of which is not bound to the main chain of the molecule, are reacted by condensation reactions, forming amide linkages; and step (2): wherein at least some of the hydroxy groups of the hydroxy-functional reaction product obtained in step (1) are reacted with at least one organic monoisocyanate, forming urethane linkages.
Owner:BYK CHEM GMBH

Cationic type gemini fluorinated surfactant based on perfluorinated nonene and perfluorinated hexene and preparation method of cationic type gemini fluorinated surfactant

The invention discloses a cationic type gemini fluorinated surfactant based on perfluorinated nonene and perfluorinated hexene and a preparation method of the cationic type gemini fluorinated surfactant. The preparation method comprises the following steps of: with the perfluorinated nonene or perfluorinated hexene as a raw material, condensing the perfluorinated nonene or perfluorinated hexene with p-hydroxybenzoic acid, and carrying out chlorination on a matter obtained after condensation and thionyl chloride to prepare perfluorinated alkene oxyl benzoyl chloride; condensing the perfluorinated alkene oxyl benzoyl chloride without separation with 2-dimethylamino ethanol, 3-dimethylamino propanol, 2-dimethylamino ethylamine and 3-dimethylamino propylamine to obtain perfluorinated alkene oxyl benzoate or perfluorinated alkene oxyl benzamide with tertiary amine at an alkanol part or amine part; and finally, condensing the perfluorinated alkene oxyl benzoate or perfluorinated alkene oxyl benzamide with 1,2-dihaloethane, 1,3-dihalopropane, 1,4-dichlorobutane, 1,5-dichloropentane or 3-oxa-1,5-dichloropentane to prepare a quaternary ammonium gemini fluorinated surfactant. The synthesized compound is high in surface activity and is low in critical micelle concentration, has the characteristics of simpleness in synthesization, low cost and the like and has good application prospect.
Owner:江苏超至和新材料有限公司

Method for testing trace carbofuran

The invention relates to the technical field of chemical pesticide test, and particularly relates to a method for testing carbofuran in carbamic acid ester pesticides, in particular to a method for testing trace carbofuran. With flour, zinc meso-tetraphenylporphine solution and phosphate buffer with the pH value of 6.5 to 7.25 as materials, the method respectively prepares zinc meso-tetraphenylporphine-plant esterase compound solution and sample mixed solution, then respectively tests the absorption spectrum curves of the zinc meso-tetraphenylporphine-plant esterase compound solution and the sample mixed solution on light waves with the wavelength of 300nm to 750nm, and compares the two tested spectrum curves; if the two spectrum curves are identical, then N, N-dimethylformamide cleaner sample to be tested does not contain carbofuran, or the content of carbofuran exceeds the test limit of the method; and if the two spectrum curves are not identical, then the sample to be tested contains carbofuran. The test cost of the method is low, the method is applicable to a wide range of regions, the precision, repeatability and stability of the test result are high, field tests can be carried out as well, the method is easy to operate, and moreover, the affection of the environment on the test result is little.
Owner:LUZHOU PINCHUANG TECH CO LTD +1

Nitric oxide donor type hexadecadrol as well as preparation method and purpose thereof

The invention relates to nitric oxide donor type hexadecadrol as well as a preparation method and application thereof. The nitric oxide donor type hexadecadrol as a compound is obtained by enabling nitrous acid ester to be connected with hexadecadrol through ethyl cyclohexanecarboxylate; the in-vitro antiinflammatory activity of the nitric oxide donor type hexadecadrol is better than that of the hexadecadrol; besides, the nitric oxide donor type hexadecadrol can restrain the growth of methicillin-resistant staphylococcus aureus (MRSA) in vitro, restrain the formation of MRSA biomembrane, and lead to the death of bacteria in the MRSA biomembrane. In addition, the compound can notably increase the survival rate of mice in MRSA sepsis lethal models, reduces the inflammation pathology damage of the mice in sub-sepsis models, decreases the constant value number of bacteria, and has notable advantages in the respect of preventing and treating MRSA sepsis.
Owner:ARMY MEDICAL UNIV

Preparation method of Sacubitril intermediate

The invention discloses a preparation method of an intermediate compound (R)-tert-butyl (1-((1,1'-diphenyl)-4-yl)-3-hydroxypropane-2-yl) carbamate. The preparation method is represented as the formulashown in the description. According to the preparation method, the steps are simple and short, the reaction yield is increased, reaction conditions are mild, most of the intermediates obtained in thereaction process are not required to be purified and can be subjected to the next reaction directly, large-batch synthesis is facilitated, chiral amine with stereospecificity is efficiently synthesized with aminotransferase, and the preparation method is more suitable for industrial production.
Owner:甘肃皓天医药科技有限责任公司

Catalyst components for the polymerization of olefins

ActiveUS20170066851A1Olefin polymerizationKetone
The present disclosure relates to a solid catalyst component for the (co)polymerization of olefins CH2═CHR, in which R is hydrogen or a hydrocarbyl radical with 1-12 carbon atoms, comprising Ti, Mg, and Cl, and optionally an electron donor compound selected from the group consisting of ethers, amines, silanes, carbamates ketones, esters of aliphatic acids, alkyl and aryl esters of optionally substituted aromatic polycarboxylic acids, diol derivatives chosen among monoesters monocarbamates and monoesters monocarbonates or mixtures thereof, comprising from 0.1 to 50% wt of Bi with respect to the total weight of the solid catalyst component.
Owner:BASSELL POLIOLEFINE ITAL SRL

P-nitrophenoxy betulin (28) formyl ester and betulin derivatives synthesized therefrom, and preparation method and application thereof

The invention discloses p-nitrophenoxy betulin (28) formyl ester and betulin derivatives synthesized therefrom, and a preparation method and an application thereof, and belongs to the technical fieldof pharmaceutical chemical. Four derivatives are synthesized with betulin as a matrix, that is to say, the tail end of a structure of the betulin is modified, a carbonacylation agent nitrophenyl chloroformate is introduced to a C-28 site, p-nitrophenoxy betulin (28) formyl ester is generated, and based on the p-nitrophenoxy betulin (28) formyl ester, four kinds of groups having biological activityand functionality are introduced. Specifically, with introduction of a structure of aminoethyl alcohol, the solubility is improved; with introduction of an N-amino morpholine group having a lysosomepositioning action and a triphenylphosphine active group having mitochondria targeted positioning, the product targetedly acts on cell organelles, the bioavailability is improved, and the higher biological activity is played; with introduction of a p-aminophenol structure, the synthesized compounds have certain antioxidant effects, and certain pharmacological activities are played by regulating the balance of redox in cells.
Owner:YANBIAN UNIV
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