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Fluorescent probe for visual detection of Cu<2+> as well as preparation method and application of fluorescent probe

A fluorescent probe, copper ion technology, applied in the field of analytical chemistry, can solve the problems of high skilled technicians, not ideal detection methods, complex instruments, etc., to achieve good water solubility, excellent optical performance, high selectivity and sensitivity. Effect

Inactive Publication Date: 2018-01-26
HEZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing determination of Cu 2+ The most common methods are atomic absorption spectrometry and spectrophotometry, but the former requires complex instruments, skilled technicians and high detection costs, while the latter requires cumbersome operations, so it is not an ideal Cu 2+ Detection method

Method used

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  • Fluorescent probe for visual detection of Cu&lt;2+&gt; as well as preparation method and application of fluorescent probe
  • Fluorescent probe for visual detection of Cu&lt;2+&gt; as well as preparation method and application of fluorescent probe
  • Fluorescent probe for visual detection of Cu&lt;2+&gt; as well as preparation method and application of fluorescent probe

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Embodiment 1

[0043] A fluorescent probe for visually detecting copper ions of the present invention is 2-(4-pyridinecarboxylate styryl)-1,3,3-trimethyl-3H-indole iodide salt, and the molecular formula is C 25 h 23 IN 2 o 2 , the structural formula is shown in formula (1):

[0044]

[0045] The above-mentioned preparation method of the fluorescent probe for visually detecting copper ions of the present invention, its synthetic route is as follows: figure 1 shown, including the following steps:

[0046] (1) synthetic compound 4-pyridinecarboxylate benzaldehyde, structural formula such as formula (2):

[0047]

[0048] The reaction formula is as formula (3):

[0049]

[0050] The specific process is: dissolve 4-hydroxybenzaldehyde (1.95g, 16mmol) in anhydrous dichloromethane, then add 2-pyridinecarboxylic acid (2.44g, 20mmol), 1-ethyl-3-(3-dimethylamino Propyl) carbodiimide hydrochloride (EDCI, 3.83g, 20mmol) and 4-dimethylaminopyridine (DMAP, 0.73g, 6mmol), the resulting mixed...

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Abstract

The invention discloses a fluorescent probe for visual detection of Cu<2+> as well as a preparation method and an application of the fluorescent probe. The fluorescent probe is 2-(4-picolinate styryl)-1,3,3-trimethyl-3H-indole iodide, and the structural formula is shown as formula (I) in the description. The preparation method comprises the following steps: (a) 4-picolinate benzaldehyde is prepared from p-hydroxybenzaldehyde and 2-picolinic acid through an esterification reaction; (b) the compound shown as the formula (I) is prepared from 4-picolinate benzaldehyde and 1 ,2 ,3 ,3-tetramethyl-3H-indole iodide through a condensation reaction. The fluorescent probe for visual detection of Cu<2+> has the advantages of high sensitivity, good selectivity, short response time and the like.

Description

technical field [0001] The invention belongs to the technical field of analytical chemistry, and in particular relates to a fluorescent probe for visually detecting copper ions, a preparation method and application thereof. Background technique [0002] Copper ions (Cu 2+ ) is the third most abundant element in the human body and plays an important role in various basic physiological processes of the organism. However, Cu in cells 2+ Changes in the concentration of methionine can lead to various diseases, including Alzheimer's disease, Mainck's syndrome, hepatolenticular degeneration, and even cancer. In addition, Cu 2+ It is widely used in industry and agriculture, so it is also a serious environmental pollutant. Therefore, looking for a simple and fast detection method for Cu 2+ Analytical testing is of great significance. Existing determination of Cu 2+ The most common methods are atomic absorption spectrometry and spectrophotometry, but the former requires complex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/12C09K11/06G01N21/64G01N21/78
Inventor 朱东建梁宁段振华任爱山唐利余倍奇陈海霞蔡毓玮蔡文
Owner HEZHOU UNIV
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