91 results about "Gastric Tissue" patented technology

Provided is a two-piece anastomosis fastener that can be used to join two tissue sections together in accordance with Natural Orifice Transendoscopic Surgery (NOTES). The fastener may be releasably attached to a fastener applying instrument for delivery in accordance with such procedures. The fastener includes a first member and a second member, where the clamp members are operably configured to fasten together to clamp and hold tissue, such as gastric tissue, in juxtaposition to establish an anastomosis. The first clamp member and the second clamp member are coupled with an adhesive.

Method and system to provide therapy for obesity, gastric motility, or to induce weight loss comprises ablating the gastric tissue around the “pacemaker” region of the stomach, and electrically pacing the stomach with a pulse generator / stimulator to control the electrical activity of the gastric muscle. The ablation to the gastric tissue may be from the epigastric side, or may be from inside the stomach. The ablation may be performed utilizing any one of: radiofrequency catheter ablation; radiofrequency catheter ablation using an irrigated tip catheter; microwave ablation; cryoablation; high intensity focused ultrasound (HIFU) ablation; and laser ablation. The ablation of the “pacemaker” region of the stomach may be partial or complete. A gastric pulse generator / stimulator is implanted to provide electrical pulses to the stomach. The function of the gastric stimulator after complete ablation of the pacemaker region, is to provide a basic electrical rhythm (BER) to regulate and control electrical activity of the stomach. Alternatively, if partial ablation is performed the function of the gastric pulse generator / stimulator is to enhance the residual basic electrical rhythm (BER), or to interfere with the residual basic electrical rhythm (BER).

An implantable device including a supporting member, such as a ring, or series of rings, and an impeding member that is used to adjust the effective area of the created orifice after implantation. The rings may hold pleats of gastric tissue in place around their circumference to create a reinforced constriction within an organ. The rings may be attached to one another with folds or pleats of tissue held between them. If the organ is a stomach, the constriction is positioned such that a chamber of a predetermined volume is created proximal to the constriction, leaving a narrow opening or stoma to the remainder of the stomach's volume distal to the constriction. At least one of the rings is adapted to have an impeding member that may be endoscopically adjusted in order to alter the size of the effective orifice area of the opening or outlet. The occluding member may be a ball suspended by a suspension line connected to opposing sides of the supporting member.

A method for creating a plication within a hollow organ. The method uses an elongated member having an end effector attached to its distal end. The end effector has a substantially hollow housing, a fixed jaw extending distally from the housing, and a retractable jaw located within the housing. The method involves the step of inserting the end effector within an organ of a patient such that it is in contact with tissue. The method also involves applying vacuum through the elongated member so as to dispose tissue on the fixed jaw and at least partially within the housing. The method also involves creating a plication by sliding the retractable jaw so that it juxtaposes the fixed jaw.

A method and device for manipulating gastric tissue about a greater curvature of a stomach. The method includes the steps of creating at least one incision to gain access to the peritoneal cavity, and dissecting at least a portion of the greater omentum. Then the method includes accessing the exterior of the gastric tissue through the incision and folding at least a portion of the greater curvature of the stomach. The fold is constructed having serosa to serosa contact substantially along its entire length. The method further involves securing the fold with a flexible member wherein the flexible member comprises at least one tissue securing feature.

A device for maintaining a plication within a hollow organ. The device includes an elongated member having distal and proximal ends. The distal end is for insertion into a body cavity. The elongated member has an end effector at its distal end. The end effector has an outer cylinder having at least one opening, and an inner cylinder having at least one opening. The inner cylinder is at least partially disposed within the outer cylinder and the cylinders are rotatable with respect to each other. The end effector is detachable from the elongated member such that it can remain within the body cavity.

A method for creating a plication within a hollow organ. The method uses an elongated member having an end effector attached to its distal end. The end effector has a substantially hollow housing, a fixed jaw extending distally from the housing, and a retractable jaw located within the housing. The method involves the step of inserting the end effector within an organ of a patient such that it is in contact with tissue. The method also involves applying vacuum through the elongated member so as to dispose tissue on the fixed jaw and at least partially within the housing. The method also involves creating a plication by sliding the retractable jaw so that it juxtaposes the fixed jaw.

Provided is a two-piece anastomosis fastener that can be used to join two tissue sections together in accordance with Natural Orifice Transendoscopic Surgery (NOTES). The fastener may be releasably attached to a fastener applying instrument for delivery in accordance with such procedures. The fastener includes a first member and a second member, where the clamp members are operably configured to fasten together to clamp and hold tissue, such as gastric tissue, in juxtaposition to establish an anastomosis. The first clamp member and the second clamp member are coupled with an adhesive.

Methods and devices for removing fasteners from tissue are described. One method is directed to surgically reversing a gastric restriction created using one or more fasteners. the fasteners can be disengaged from the gastric tissue and subsequently removed from the gastric tissue site. The method can utilize an endoscopically delivered fastener-extraction device to sever the fasteners by applying energy. In an exemplary device for removing fasteners, a substantially elongate body can include a fastener catch for selectively engaging tissue-attached fasteners. The device can also include a fastener-severing member and at least one fastener-removal element. The fastener-removal element can be adapted to be an energy delivery member that delivers an argon plasma to sever fasteners, while the fastener catch is adapted to shield tissue from direct energy contact.

The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of colorectal, in particular colonic, and gastric tumor tissues and colorectal, in particular colonic, and gastric tissues, and which represent targets for therapy or diagnosis of such tumor diseases in a subject.

A device for creating a plication within a hollow organ. The device has an elongated member with distal and proximal ends. The distal end is for insertion into a body cavity. The elongated member has an end effector at its distal end. The end effector includes an outer cylinder having at least one opening in its cylindrical wall. The end effector also has an inner cylinder having at least one opening in its cylindrical. The inner cylinder is at least partially disposed within the outer cylinder such that the apertures can at least partially overlap. In addition, the cylinders are rotatable with respect to each other. In addition, the device includes a tubular channel running through the elongated member which is in fluid communication with the end effector. The channel has a vacuum source attached at its proximal end.

A device for creating a plication within a hollow organ. The device includes an elongated member having distal and proximal ends. The device has an end effector attached to the distal end of the elongated member. The end effector has a substantially hollow housing, a fixed jaw extending distally from the housing, and a retractable jaw located within the housing. The jaw is slidable distally such that the retractable jaw can juxtapose the fixed jaw.

The invention discloses a low expression piRNA probe for stomach tissue. The sequence of the probe consists of a chemically modified oligonucleotide coding fragment and an extendible arm fragment, wherein the oligonucleotide coding fragment is at least one of the following piRNA sequences: hsa_piR_000370, hsa_piR_009567, hsa_piR_000216, hsa_piR_000728, hsa_piR_010229, hsa_piR_000990, hsa_piR_000460, hsa_piR_006105, hsa_piR_005837, hsa_piR_007743, hsa_piR_009884, hsa_piR_000001 and hsa_piR_004611. The probe can carry out the hybridization detection of piRNAs of the stomach tissue and detect the piRNAs with abnormally low expression in the stomach tissue. As diagnosis markers of canceration of the stomach tissue, the piRNAs can further serve as targets of designing directional stomach cancer drugs. Therefore, the probe provides the useful reference for the diagnosis and directional treatment of stomach cancer.

An implantable device including a supporting member, such as a ring, or series of rings, and an impeding member that is used to adjust the effective area of the created orifice after implantation. The rings may hold pleats of gastric tissue in place around their circumference to create a reinforced constriction within an organ. The rings may be attached to one another with folds or pleats of tissue held between them. If the organ is a stomach, the constriction is positioned such that a chamber of a predetermined volume is created proximal to the constriction, leaving a narrow opening or stoma to the remainder of the stomach's volume distal to the constriction. At least one of the rings is adapted to have an impeding member that may be endoscopically adjusted in order to alter the size of the effective orifice area of the opening or outlet. The occluding member may be a ball suspended by a suspension line connected to opposing sides of the supporting member.

A method of implanting a device to maintain a plication within a hollow organ. The method uses an elongated member having an end effector at its distal end. The end effector has an outer cylinder having at least one opening, and an inner cylinder having at least one opening. The inner cylinder is at least partially disposed within the outer cylinder and the cylinders are rotatable with respect to each other. The end effector is detachable from the elongated member such that it can remain within the body cavity. The method involves the step of inserting the end effector within the organ of a patient such that it is in contact with tissue. The method also involves the step of applying vacuum through the elongated member so as to dispose tissue within the inner cylinder. The method also involves the step of creating a plication by rotating the cylinders with respect to each other. The method also involves the step of detaching the end effector from the elongated member.

A device for maintaining a plication within a hollow organ. The device includes an elongated member having distal and proximal ends. The distal end is for insertion into a body cavity. The elongated member has an end effector at its distal end. The end effector has an outer cylinder having at least one opening, and an inner cylinder having at least one opening. The inner cylinder is at least partially disposed within the outer cylinder and the cylinders are rotatable with respect to each other. The end effector is detachable from the elongated member such that it can remain within the body cavity.

A device for creating a plication within a hollow organ. The device has an elongated member with distal and proximal ends. The distal end is for insertion into a body cavity. The elongated member has an end effector at its distal end. The end effector includes an outer cylinder having at least one opening in its cylindrical wall. The end effector also has an inner cylinder having at least one opening in its cylindrical. The inner cylinder is at least partially disposed within the outer cylinder such that the apertures can at least partially overlap. In addition, the cylinders are rotatable with respect to each other. In addition, the device includes a tubular channel running through the elongated member which is in fluid communication with the end effector. The channel has a vacuum source attached at its proximal end.

A method for creating a plication within a hollow organ. The method uses an elongated member having an end effector at its distal end. The end effector has an outer cylinder having at least one opening in its cylindrical wall, and an inner cylinder having at least one opening in its cylindrical wall. The inner cylinder is at least partially disposed within the outer cylinder such that the apertures can at least partially overlap. The cylinders are rotatable with respect to each other. The method includes the step of inserting the end effector within an organ of a patient such that it is in contact with tissue. The method also involves applying vacuum through the elongated member so as to dispose tissue within the inner cylinder. The method also involves creating a plication by rotating the cylinders with respect to each other.

A device for creating a plication within a hollow organ. The device includes an elongated member having distal and proximal ends. The device has an end effector attached to the distal end of the elongated member. The end effector has a substantially hollow housing, a fixed jaw extending distally from the housing, and a retractable jaw located within the housing. The jaw is slidable distally such that the retractable jaw can juxtapose the fixed jaw.

The invention aims at preparing a hybrid tumor of an anti-antrum mucosalprotein-18 (AMP-18) monoclonal antibody and relates to application thereof in preparing a tumor clinical detection reagent. Particularly, in the invention, a hybrid tumor cell (70110-4) capable of secreting the monoclonal antibody specifically recognizing the AMP-18 is screened through a molecular cloning technology and a monoclonal antibody technology. The monoclonal antibody secreted by the 70110-4 can be used for the clinical detection of carcinoma lesion in gastric tissues of human bodies.

Disclosed are methods of inducing formation of a gastric cells and / or a gastric tissue, such as in the form of a gastric organoid. The formation of gastric cells and / or tissue may be carried out by the activating and / or inhibiting of one or more signaling pathways within a precursor cell. Also disclosed are methods for using the disclosed gastric cells, gastric tissues, and / or gastric organoids derived from precursor cells.

The invention belongs to the technical field of medical equipment, and particularly relates to an endogastric biopsy Raman image auxiliary diagnosis method and system based on artificial intelligence. The artificial intelligence technology is applied to gastroscope stimulated Raman scattering endoscopic biopsy tissue image auxiliary diagnosis for the first time, and the method comprises the step: after histopathology image information is obtained by means of the stimulated Raman scattering microimaging technology, adopting the image classification and image omics data analysis based on a deep learning neural network and machine learning, and constructing an endogastric biopsy Raman image auxiliary diagnosis system. The system comprises a stomach tissue Raman image data preprocessing module, a neural network model, an algorithm module for training the neural network model, a neural network fine tuning module and a test module; compared with an existing traditional endoscope diagnosis and treatment system, the system has the advantages that real-time, rapid and intelligent diagnosis support in the endoscope examination process is achieved, and pathologists do not need to conduct explanation.

It is an objective of the present invention to provide a highly stable and reproducible method for detecting gastric cancer, by finding a novel gastric cancer-related gene and detecting the inactivation of such cancer-related gene. The present invention provides a method for detecting gastric cancer, comprising detecting malignant transformation of a gastric tissue cell by detecting the inactivation of the human VLDLR gene in the gastric tissue cell.

The inventor finds out a cell population (named as gastric cancer very early cells) which starts to appear in the low-grade heteroplasmal hyperplasia stage of the stomach, has specific molecular characteristics and has a high canceration risk, and the cell population can be used as a marker for very early diagnosis of gastric cancer. Molecular markers of gastric cancer extremely-early cells are applied to preparation of a kit for realizing early diagnosis of gastric cancer or other digestive system tumors based on gastric tissues or blood samples. The gastric cancer extremely-early cell markercan also distinguish the postoperative recurrence risk of gastric cancer and the tumor risk of digestive system organs such as intestines, pancreas and esophagus. Besides, the inventor also finds outa cell population which appears in the early stage of gastric precancerous lesions and has specific molecular characteristics, and the cell population can be used as a marker for early diagnosis of gastric precancerous lesions and is also integrated into the kit. The markers and kits can be used for early clinical diagnosis of gastric cancer and other digestive tract tumors, can also be used as an intervention target for prevention and treatment of the digestive tract tumors, and have a good application prospect.

A method of implanting a device to maintain a plication within a hollow organ. The method uses an elongated member having an end effector at its distal end. The end effector has an outer cylinder having at least one opening, and an inner cylinder having at least one opening. The inner cylinder is at least partially disposed within the outer cylinder and the cylinders are rotatable with respect to each other. The end effector is detachable from the elongated member such that it can remain within the body cavity. The method involves the step of inserting the end effector within the organ of a patient such that it is in contact with tissue. The method also involves the step of applying vacuum through the elongated member so as to dispose tissue within the inner cylinder. The method also involves the step of creating a plication by rotating the cylinders with respect to each other. The method also involves the step of detaching the end effector from the elongated member.

Devices and methods of forming a compliant gastroplasty are presented. In general, fasteners that can reversibly couple are inserted into gastric tissue to form a gastric restriction. When an expanding pressure in the stomach exceeds a certain limit, the coupled fasteners can decouple to accommodate and relieve the excess pressure. Upon subsequent stomach shrinkage, fasteners are brought back into proximity and recouple to reform the gastroplasty. In particular, magnetic fasteners can be inserted into gastric tissue by injecting a solidifying composition into the tissue to form the fasteners. Various devices and methods for forming the gastroplasty are discussed.

The invention provides a peritoneal preperitoneal hernia repair operation training model and a manufacturing method and a storage method thereof, and relates to the technical field of medical treatment. According to the manufacturing method of the peritoneal preperitoneal hernia repair operation training model, the stomach tissue serves as the main raw material, the texture of the focus tissue, the structure of the actual focus and the blood vessel trend are fully simulated, and the manufacturing method is simple, rapid, convenient to obtain and low in cost. According to the peritoneal preperitoneal hernia repair operation training model, the training model is made of main raw materials of stomach tissue, the texture of focus tissue and the touch and force feedback of real operation are fully simulated, a reliable training model is provided for medical staff, the operation skill is improved, and meanwhile, the training environment requirement of the training model is simple, investmentof places, cost, manpower and the like is saved, and surgical training is daily.

The invention provides a system and method for automatically screening and labeling helicobacter pylori, and the method mainly comprises the following steps: (1) selecting gastric tissue slices with expert diagnosis information, including helicobacter pylori positive and negative slices; (2) scanning and converting conventional slice into a digital pathological slices by using a slice scanner to serve as a digital pathological image database; (3) enabling a pathologist to mark the helicobacter pylori in the digital slices and take the marked helicobacter pylori as an helicobacter pylori database; (4), analyzing and learning the digital pathological image database and the helicobacter pylori database by using a deep learning algorithm and an image processing method, and establishing a digital pathological image automatic diagnosis model; (5) diagnosing a digital pathological slice of an unknown lesion by using the digital pathological image automatic diagnosis model established in the step (4), automatically labeling and identifying the helicobacter pylori, and feeding back the labeled diagnosis result to the pathologist to assist the pathologist in diagnosis.

The invention discloses a composite self-emulsifying soft haematococcus pluvialis astaxanthin capsule as well as a preparation method and an application thereof. The soft capsule comprises a capsule core and a capsule wall, and the capsule core contains haematococcus pluvialis astaxanthin or haematococcus pluvialis astaxanthin extract, vegetable oil, an emulsifier, a co-emulsifier and an antioxidant. The vegetable oil, the antioxidant and haematococcus pluvialis astaxanthin are stirred uniformly, a mixed emulsifier is prepared from an obtained solution with the emulsifier and the co-emulsifier, uniform stirring and filtration are performed, and a self-emulsifying system is obtained; a soft capsule material liquid and the self-emulsifying system are added to a soft capsule making machine, and the composite self-emulsifying soft haematococcus pluvialis astaxanthin capsule is obtained. The soft capsule is prepared from haematococcus pluvialis astaxanthin and the optimized vegetable oil byreasonable combination, has high dispersibility and excellent storage stability, and can enhance anti-fatigue ability and learning and memory ability of an aging model rat, improve activity of SOD (superoxide dismutase) in gastric tissue, reduce MDA (malondialdehyde) content and scavenge free radicals in vivo.