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Composite self-emulsifying soft haematococcus pluvialis astaxanthin capsule as well as preparation method and application thereof

A technology of self-emulsifying soft capsules and Haematococcus pluvialis, applied in the field of medicine, can solve the problems of easy oxidation and easy damage, and achieve the effects of removing free radicals in the body, increasing the concentration, and having good anti-aging effects.

Active Publication Date: 2019-06-18
广东现代汉方科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the molecule of Haematococcus pluvialis astaxanthin contains conjugated double bonds, and there are unsaturated ketone groups and hydroxyl groups at the end of the molecule, the electronic effect is relatively active, which can attract unpaired electrons in free radicals and scavenge free free radicals , produces anti-oxidation effect, and it is precisely because of this structure that Haematococcus pluvialis astaxanthin is extremely sensitive to light, heat, and oxygen. It is easy to oxidize when placed in the air for a long time, and its molecular structure is easily destroyed by high temperature

Method used

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  • Composite self-emulsifying soft haematococcus pluvialis astaxanthin capsule as well as preparation method and application thereof
  • Composite self-emulsifying soft haematococcus pluvialis astaxanthin capsule as well as preparation method and application thereof
  • Composite self-emulsifying soft haematococcus pluvialis astaxanthin capsule as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1 Compound Haematococcus pluvialis astaxanthin self-emulsifying soft capsule one

[0058] (1) Composition is as shown in table 1:

[0059] Table 1

[0060]

[0061] (2) Preparation method (the consumption of each composition is as shown in table 1)

[0062] 1) Add Haematococcus pluvialis astaxanthin into the ingredient container, add peony seed oil and vitamin E in sequence at 50°C, stir at a slow speed (40-50rpm) for 35 minutes, and filter to obtain the compound pluvialls red ball Algae astaxanthin keep warm, set aside.

[0063] 2) Mix soybean lecithin and glycerin, stir twice with a shearing machine (8000 rpm), 5 minutes for the first time, and 2 minutes for the second time; make it evenly dispersed, add the warm water prepared in step 1) The compound Haematococcus pluvialis astaxanthin was stirred 3 times for 5 minutes each time, and filtered to form a uniform liquid, and the compound Haematococcus pluvialls astaxanthin self-emulsification system was...

Embodiment 2

[0068] Example 2 Compound Haematococcus Pluvialls Astaxanthin Self-emulsifying Soft Capsule II

[0069] (1) Composition is as shown in table 2:

[0070] Table 2

[0071]

[0072] (2) Preparation method

[0073] 1) Add Haematococcus pluvialis astaxanthin into the ingredient container, add peony seed oil, perilla seed oil, vitamin E and vitamin C in sequence at 45°C, stir at a slow speed (40-50rpm) for 50 minutes, After filtering, the compound Haematococcus pluvialis astaxanthin is obtained, kept warm and set aside.

[0074] 2) Mix egg yolk lecithin, ethanol and glycerin, stir twice with a shearing machine (8000 rpm), 10 minutes for the first time, and 8 minutes for the second time, to make it disperse evenly; add the warm water prepared in step 1). The hot compound Haematococcus pluvialls astaxanthin was stirred 3 times for 5 minutes each time, and filtered to form a uniform liquid, and the compound Haematococcus pluvialls astaxanthin self-emulsification system was obtain...

Embodiment 3

[0079] Example 3 Compound Haematococcus Pluvialls Astaxanthin Self-emulsifying Soft Capsule Three

[0080] (1) Composition is as shown in table 3:

[0081] table 3

[0082]

[0083] (2) Preparation method

[0084] 1) Add Haematococcus pluvialis astaxanthin into the ingredient container, add peony seed oil, perilla seed oil, eucommia ulmoides seed oil, vitamin E and vitamin C in sequence at 56°C, stir slowly for 35 minutes, filter Afterwards, compound Haematococcus pluvialis astaxanthin was obtained, kept warm, and set aside.

[0085] 2) Mix liquid lecithin, ethanol and glycerin, and stir twice with a shearing machine (8000 rpm), 15 minutes for the first time, and 10 minutes for the second time, to make it disperse evenly; Haematococcus astaxanthin, stirred 3 times, 5 minutes each time, filtered to form a uniform liquid, that is, the compound Haematococcus pluvialis astaxanthin self-emulsifying system.

[0086] 3) Add gelatin into the sol tank, add distilled water with a...

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Abstract

The invention discloses a composite self-emulsifying soft haematococcus pluvialis astaxanthin capsule as well as a preparation method and an application thereof. The soft capsule comprises a capsule core and a capsule wall, and the capsule core contains haematococcus pluvialis astaxanthin or haematococcus pluvialis astaxanthin extract, vegetable oil, an emulsifier, a co-emulsifier and an antioxidant. The vegetable oil, the antioxidant and haematococcus pluvialis astaxanthin are stirred uniformly, a mixed emulsifier is prepared from an obtained solution with the emulsifier and the co-emulsifier, uniform stirring and filtration are performed, and a self-emulsifying system is obtained; a soft capsule material liquid and the self-emulsifying system are added to a soft capsule making machine, and the composite self-emulsifying soft haematococcus pluvialis astaxanthin capsule is obtained. The soft capsule is prepared from haematococcus pluvialis astaxanthin and the optimized vegetable oil byreasonable combination, has high dispersibility and excellent storage stability, and can enhance anti-fatigue ability and learning and memory ability of an aging model rat, improve activity of SOD (superoxide dismutase) in gastric tissue, reduce MDA (malondialdehyde) content and scavenge free radicals in vivo.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound Haematococcus pluvialis astaxanthin self-emulsifying soft capsule and its preparation method and application. Background technique [0002] Haematococcus pluvialis astaxanthin is a hydrophobic substance extracted from the single-celled green alga Haematococcus pluvialis of the family Haematococcus, and its chemical name is 3,3'-dihydroxy-4,4 '-Diketo-β,β'-carotene, molecular formula C 40 h 52 o 4 , with a molecular mass of 596.84, is the only oxygen-containing derivative of carotenoids that can pass through the blood-brain barrier. See figure 1 ), insoluble in water and fat-soluble. The structure of astaxanthin can be divided into 4 optical isomers according to the positional relationship between the hydroxyl group and the entire molecular plane. The astaxanthin product accumulated by Haematococcus pluvialis is a pure S conformation. Studies have shown that asta...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/44A61K31/122A61P39/06
Inventor 李吉来王兴林李肇联刘少勇郑泽苗练庆旺
Owner 广东现代汉方科技有限公司
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