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380results about How to "Inhibition production" patented technology
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Use of bi-specific antibodies for pre-targeting diagnosis and therapy
InactiveUS20030198595A1Increase productionImproved chemotherapyAntibacterial agentsUltrasonic/sonic/infrasonic diagnosticsEpitopeDiagnostic agent
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
Owner:IMMUNOMEDICS INC
Footwear system
Owner:TRANSFORM SR BRANDS LLC
Use of hyaluronic acid and forms to prevent arterial restenosis
InactiveUS6022866APrevent restenosis of the arterial wallsPrevent restenosisBiocidePharmaceutical delivery mechanismPercent Diameter StenosisHyaluronic acid
PCT No. PCT / CA93 / 00388 Sec. 371 Date Mar. 24, 1995 Sec. 102(e) Date Mar. 24, 1995 PCT Filed Sep. 22, 1993 PCT Pub. No. WO94 / 07505 PCT Pub. Date Apr. 14, 1994A method is provided of inhibiting the narrowing of the vascular tubular walls of an animal by the proliferation of endothelial cells in the area of trauma after the vascular tubular walls have been traumatized, the method comprising the administration of a therapeutically effective non-toxic amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof to the animal to inhibit the narrowing of the vascular tubular walls by the proliferation of endothelial cells into the area of trauma.
Owner:PRICEWATERHOUSECOOPERS +1
Novel anti-IL13 antibodies and uses thereof
ActiveUS20090214523A1Inhibiting antibody productionRelieve symptomsSenses disorderAntipyreticUveitisNonallergic rhinitis
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
Owner:GENENTECH INC
Footwear system
A footwear system has a sole unit with a number of cavities formed between a midsole and an outsole. The cavities are complementary to one another to form groundward oriented air bulges in the outsole that are connected by a passage formed in the midsole. The passage permits movement of air between the cavities during use of the footwear system in a shoe.
Owner:TRANSFORM SR BRANDS LLC
Method of treating acne
InactiveUS7018396B2Reduce and prevent production of sebumReduce sebum productionDiagnosticsSurgical instrument detailsTreatment acneSebaceous gland secretion
A method of selectively enhancing photothermal sebaceous gland disruption and treatment of acne is disclosed. The method provides for alleviation of the acne symptoms as well as preventing acne recurrence and new acne from occurring.
Owner:CYNOSURE +1
Composition for odor control
ActiveUS20050115895A1Promote growthInhibition productionSpecific water treatment objectivesWater contaminantsSpecific enzymeWaste stream
A synergistic composition is provided for controlling odor from waste products. The composition comprises a combination of nitrate salt, sulfide-consuming compound, pH-elevating compound, sulfide-oxidizing, nitrate-reducing bacteria, and sulfide-oxidizing enzyme. The method includes adding a sufficient amount of the composition to a waste stream to provide sufficient sulfide-consuming compound to effect immediate removal of sulfide. The composition incorporates a pH elevating compound, which both decreases the amount of gaseous H2S and puts the aqueous phase into a pH range where naturally occurring bacteria can more easily metabolize the sulfide. The composition also includes one or more nitrate salts which will accomplish longer term prevention of odors. Specific bacteria are incorporated into the formulation to insure that the nitrate has the right type and amount of bacteria present to prevent formation of and / or consume sulfide. Specific enzymes are incorporated into the formulation to promote oxidation of sulfide.
Owner:EVOQUA WATER TECH LLC
Device and method for treating workpieces
ActiveUS20060099340A1Inhibition productionAvoid and reduce extentLiquid surface applicatorsConveyorsFluid controlHigh flux
An apparatus and a method for the coating of hollow bodies, in particular for the internal coating of plastic drinks bottles by means of a PICVD is provided. The method ensures a flexible process sequence, a high throughput, an improved supply of fluid and a high-quality coating. The rotary apparatus includes a treatment device with double reactors for receiving in each case at least one workpiece, a fluid supply apparatus and at least one fluid control device, which can be used to control the supply of fluid to the treatment device. It is preferable for the vacuum pumps to be arranged on the rotor such that they rotate therewith.
Owner:SCHOTT AG
C-nitroso compounds and use thereof
InactiveUS6887994B2Inhibition productionReduce impactAntibacterial agentsOrganic chemistryNitrosoNo donors
A C-nitroso compound having a molecular weight ranging from about 225 to about 1,000 (from about 225 to about 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. In another case, the C-nitroso compound contains the moiety—C—N(O)X—where X is S, O or NR. One embodiment is directed to COX-2 inhibitors where a tertiary carbon atom and / or an oxygen atom and / or a sulfur atom is nitrosylated.
Owner:DUKE UNIV
Ink-jet printing apparatus
InactiveUS20050140764A1Good flexibilityImprove throughputSolid-state devicesSemiconductor/solid-state device manufacturingInk printerEngineering
An ink-jet printing apparatus for printing at least one organic material on a substrate comprises a delivering chamber, a loading mechanism, at least one ink-jet printing mechanism, a heat treatment process mechanism and an unloading mechanism. In this case, the delivering chamber has a delivering unit, which carries the substrate from the loading mechanism and carries the substrate to the unloading mechanism. The ink-jet printing mechanism connects to the delivering chamber and prints the organic material on the substrate. The heat treatment process mechanism connects to the delivering chamber and heats the substrate on which the organic material is formed. The unloading mechanism connects with the delivering chamber.
Owner:RITDISPLAY
Guanylhydrazones and their use to treat inflammatory conditions
InactiveUS6180676B1Inhibit productionLimit and prevent damageUrea derivatives preparationBiocideDiseaseAbnormal tissue growth
This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone (more properly termed amidinohydrazone) compositions and their use to inhibit the uptake of arginine by macrophages and / or its conversion to urea. These compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections.
Owner:FERRING BV
Process apparatus, and composition for calcium fortification of beverages
InactiveUS20020122866A1Inhibit productionReduce presenceFood ingredientsFood preparationCalcium hydroxideSufficient time
Process, apparatus and composition for calcium fortification of beverages are provided. The methods comprise continuously blending in water a calcium source, preferably calcium hydroxide, and an acid source for a time sufficient to produce soluble calcium salts, but with minimal precipitation. The acid source is preferably citric acid. The calcium salt solution remains in an in-line retaining reaction hold tube for the necessary period to produce calcium salt in solution without significant precipitation, and is then continuously and immediately added to a non-dairy beverage, such as orange juice, to calcium fortify the beverage. The pH of the calcium salt solution can be monitored to optimize the amount of soluble salt and minimize the amount of precipitate.
Owner:THE COCA-COLA CO
Lid for Airtight Containers
ActiveUS20090218360A1Increased durabilityInhibition productionCapsClosure capsEngineeringMechanical engineering
Disclosed herein is a lid for airtight containers. The lid according to the present invention includes a plurality of locking flap handles, which are coupled to a lid body so as to be rotatable, and each of which has a locking protrusion to be locked to a locking depression formed in the outer edge of the upper end of a container body. The locking flap handles are connected to the lid body by respective film hinges. The film hinge includes an elastic hinge part, which is continuous with the upper surface of the lid without having a stepped portion and is curved outwards at a predetermined curvature, and a connection part, which connects the elastic hinge part to the locking flap handle. The connection part extends a predetermined length to disperse an impact generated when the locking flap handle is locked to the container body. Thus, when the locking flap handle is locked to the container body, the elastic hinge part is folded around an inner corner, which forms a boundary between the elastic hinge part and the lid body, and is elastically brought into contact with the outer surface of the lid body.
Owner:SUK JONG CHEUL
C-nitroso compounds and use thereof
InactiveUS20050187166A1Improve mitigation effectInhibition productionBiocideOrganic chemistryNitrosoOral medication
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. When the compound is obtained from a carbon acid with a pKa less than about 10, it provides vascular relaxing effect when used at micromolar concentrations and this activity is potentiated by glutathione to be obtained at nanomolar concentrations. When the compound is obtained from a carbon acid with a pKa ranging from about 15 to about 20, vascular relaxing effect is obtained at nanomolar concentrations without glutathione. In another embodiment, a biocompatible polymer incorporates a C-nitroso moiety.
Owner:DUKE UNIV
Method for nickel and cobalt recovery from laterite ores by combination of atmospheric and moderate pressure leaching
InactiveUS20060024224A1Efficient leachingEfficient separationIron compoundsCobalt compoundsRecovery methodIon exchange
A process for leaching laterite ores containing limonite and saprolite. Sufficient mineral acid is added to a slurry of limonite which is leached at atmospheric pressure to dissolve most of the soluble non-ferrous metals and soluble iron. After adding saprolite the slurry is further leached at a temperature above the normal boiling point and at a pressure above atmospheric pressure for a time sufficient to leach most of the contained nickel in the saprolite and to precipitate most of the iron in solution. The pressure of the slurry is then reduced, and nickel and / or cobalt is subsequently recovered from the leach solution by solvent extraction, resin-in-pulp or other ion exchange, sulfide or hydroxide precipitation, or other recovery method.
Owner:SKYE RESOURCES
C-nitroso compounds and use thereof
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. When the compound is obtained from a carbon acid with a pKa less than about 10, it provides vascular relaxing effect when used at micromolar concentrations and this activity is potentiated by glutathione to be obtained at nanomolar concentrations. When the compound is obtained from a carbon acid with a pKa ranging from about 15 to 20, vascular relaxing effect is obtained at nanomolar concentrations without glutathione. In another embodiment, a biocompatible polymer incorporates a C-nitroso moiety.
Owner:DUKE UNIV
Laser focusing optical system
Owner:OLYMPUS CORP
Absorbent and Column for Extracorporeal Circulation
InactiveUS20090275874A1Prolong lifeImprove the quality of lifeSemi-permeable membranesHaemofiltrationExtracorporeal circulationZeta potential
The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of −20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.
Owner:TORAY IND INC
Plant for the generation of electricity
InactiveUS20090072538A1Easy to captureInhibit productionFluidized bed combustionGas turbine plantsElectricityCyclone
A plant for generating electricity includes a gas turbine, a compressor driven by the gas turbine, a reduction reactor configured to reduce metal oxides, fed with a fuel and having a first circulating fluidized bed, a first cyclone configured to separate the metal oxide solids, and feeding at least a portion of the metal oxide solids to the reduction reactor via a first connecting line, an oxidation reactor configured to oxidize the metal oxides having a second circulating fluidized bed and fed only with pressurized air from the compressor, and a second cyclone configured to separate the metal oxide solids and feeding at least a portion of the metal oxide solids to the oxidation reactor via a second connecting line.
Owner:GENERAL ELECTRIC TECH GMBH
Lid having locking flap handles with improved elastic hinges for airtight containers
ActiveUS7854344B2Increased durabilityInhibition productionCapsClosure capsEngineeringMechanical engineering
A lid for an airtight container has a rim part for sealing to the container and plural locking flap handles extending from the rim part and rotating between open and locked positions. Each handle has a locking protrusion for locking to the container in its locked position, and a film hinge with an outer surface that smoothly curves continuously into an upper surface of the rim part of the lid, in the open position of the handle. The film hinge has an elastic hinge part that extends by a predetermined length to disperse an impact generated when the handle is locked to the container and the elastic hinge part is folded as the handle is moved from its open to its locked position.
Owner:SUK JONG CHEUL
Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
InactiveUS20050265924A1Inhibiting transcriptionInhibition of translationOrganic active ingredientsHydrolasesTissue specificNucleic acid
A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and / or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit a humoral or cellular immune response.
Owner:AGENSYS
Removing odoriferous sulfides from wastewater
ActiveUS7285217B2Promote growthInhibition productionSpecific water treatment objectivesWater contaminantsSpecific enzymeWaste stream
A synergistic composition is provided for controlling odor from waste products. The composition comprises a combination of nitrate salt, sulfide-consuming compound, pH-elevating compound, sulfide-oxidizing, nitrate-reducing bacteria, and sulfide-oxidizing enzyme. The method includes adding a sufficient amount of the composition to a waste stream to provide sufficient sulfide-consuming compound to effect immediate removal of sulfide. The composition incorporates a pH elevating compound, which both decreases the amount of gaseous H2S and puts the aqueous phase into a pH range where naturally occurring bacteria can more easily metabolize the sulfide. The composition also includes one or more nitrate salts which will accomplish longer term prevention of odors. Specific bacteria are incorporated into the formulation to insure that the nitrate has the right type and amount of bacteria present to prevent formation of and / or consume sulfide. Specific enzymes are incorporated into the formulation to promote oxidation of sulfide.
Owner:EVOQUA WATER TECH LLC
Thienodipyridine derivatives, production and use thereof
InactiveUS6214838B1Low toxicityStable to metabolismBiocideOrganic chemistryAutoimmune conditionHydrogen
A compound of the formula (I):wherein R is hydrogen or C2-6 alkanoyl; X is halogen; and ring A is benzene ring which is optionally substituted by 1 to 4 substituents selected from {circle around (1)} halogen, {circle around (2)} hydroxy, {circle around (3)} C1-6 alkoxy optionally substituted by halogen or phenyl, {circle around (4)} C1-6 alkylthio optionally substituted by halogen or phenyl, {circle around (5)} C1-6 alkyl optionally substituted by halogen, {circle around (6)} C2-6 alkanoylamino or {circle around (7)} carboxy optionally esterified by C1-6 alkyl, or a salt thereof; which can be used for preventing or treating inflammatory disease, arthritis, chronic rheumatoid arthritis, autoimmune diseases, or rejection after organ transplantation.
Owner:TAKEDA PHARMA CO LTD
si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation
InactiveUS7504385B2Inhibit productionImprove aestheticsBiocideSugar derivativesHypopigmentationOligomer
Owner:AVON PROD INC
Method of treating acne
InactiveUS20060128771A1Reduce and prevent production of sebumReduce and prevent and eliminate occurrence and reoccurrenceBiocideElectrotherapyTreatment acnePharmacology
Owner:CYNOSURE
Cold storage solution for organ and biological tissue preservation
InactiveUS20020064768A1Increase storage spacePotent vasodilatory propertyBiocideTetrapeptide ingredientsNitric oxideBiological activation
Cold storage solutions for the preservation of organs and biological tissues prior to implantation, including a prostaglandin having vasodilatory, membrane stabilizing, platelet aggregation prevention upon reperfusion, and complement activation inhibitory properties, a nitric oxide donor, and a glutathione-forming agent.
Owner:ORGAN RECOVERY SYST
Vehicle body structure
InactiveUS20050046236A1Improve rigidityAvoid deformationVehicle seatsUnderstructuresImpact energyAerospace engineering
A vehicle body structure with a floor panel having rigidity to withstand an impact energy at an offset collision of the vehicle is provided. The floor panel has a plurality of beads formed in a direction in which an impact energy acts. The beads are formed in the floor panel such that they extend obliquely rearward from left and right floor frame members toward the transversal center and are aligned longitudinally of the vehicle body.
Owner:HONDA MOTOR CO LTD
Diesel engine system with exhaust gas recirculation
ActiveUS20080202118A1Suppresses smoke productionIncrease loadElectrical controlInternal combustion piston enginesEngineeringExhaust gas recirculation
A diesel engine system includes a diesel engine, a throttle valve, an EGR (Exhaust Gas Recirculation) path, an EGR valve and a controller. The throttle valve controls a flow rate of intake air to the diesel engine. Exhaust gas is recirculated along the EGR path from an exhaust port to an intake port of the diesel engine. The EGR valve controls a flow rate of the exhaust gas. The controller controls the throttle valve and the EGR valve such that an opening of the throttle valve decreases and an opening of the EGR valve increases when a load of the diesel engine increases. The controller controls the EGR valve such that the opening of the EGR valve increases after the opening of the EGR valve is held constant for a first predetermined holding time.
Owner:MITSUBISHI HEAVY IND ENGINE & TURBOCHARGER LTD
Double-side polishing carrier and fabrication method thereof
InactiveUS20070184662A1Efficient preparationIncrease production costDecorative surface effectsSemiconductor/solid-state device manufacturingDiamond-like carbonSurface roughness
The carrier (10) for double-side polishing has a base material 10a the material of which is stainless steel (SUS) , for example, as is before, and the base material 10a is coated with a coating layer 10b of a material having a hardness higher than that of the base material 10a. The coating layer 10b is desirably coated uniformly without variations in thickness and not warped easily, and the material for the coating layer 10b of the double-side polishing carrier 10 is desirably any one selected from diamond-like carbon, a nitride film, a sapphire film and a titanium nitride film. For production of the double-side polishing carrier 10, a double-side polishing carrier 10′ having been used for polishing is prepared first. The used carrier 10′ is coated with the coating layer 10b. The invention can suppress the progress of abrasion of the double-side polishing carrier, and can provide satisfactory thickness accuracy, film thickness distribution accuracy, and surface roughness.
Owner:SUMCO TECHXIV
Nonaqueous electrolyte solution and nonaqueous electrolyte secondary battery using same
ActiveCN104584309AImprove load characteristicsExcellent cycle characteristicsNon-aqueous electrolyte accumulator electrodesLi-accumulatorsPhysical chemistryCarboxylic acid
The objective of the present invention is to provide: a nonaqueous electrolyte solution which improves cycle characteristics and load characteristics, while suppressing the generation of a gas; and a nonaqueous electrolyte secondary battery which uses this nonaqueous electrolyte solution. The present invention relates to a nonaqueous electrolyte solution which is used in a nonaqueous electrolyte secondary battery that is provided with a positive electrode and a negative electrode that have active materials capable of absorbing and desorbing metal ions. This nonaqueous electrolyte solution contains a compound represented by general formula (1), and additionally contains a specific amount of a carboxylic acid or at least one compound that is selected from the group of specific compounds such as a cyclic carbonate compound having an unsaturated bond.
Owner:MITSUBISHI CHEM CORP +1
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