51 results about "Clinical syndrome" patented technology

This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly woman for which no effective means of prevention or alleviation has heretofore been available.

This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone (more properly termed amidinohydrazone) compositions and their use to inhibit the uptake of arginine by macrophages and / or its conversion to urea. These compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections.

This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone (more properly termed amidinohydrazone) compositions and their use to inhibit the uptake of arginine by macrophages and / or its conversion to urea. These compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections.

The invention relates to liver-protecting alcoholism-relieving plant beverage, which comprises the following components: hawthorn, sealwort, ordate houttuynia, kudzu root, malt (fried),liquorice and cornoligopeptide powder. The invention also relates to a preparation method of the plant beverage. The plant beverage can obviously relieve the damage of liver, spleen and stomach caused by alcohol. The plant beverage has remarkable effect on relieving nausea, vomitting, dizzy and dry throat after drinking wine; and the plant beverage tastes sweet and sour, the clinical syndrome can be remarkably improved, and no obvious untoward effect occurs.

The invention discloses a Chinese patent medicine for treating vascular dementia and a preparation method thereof. The Chinese patent is prepared from the following raw materials in parts by weight: 15-20 parts of prepared rehmannia, 10-15 parts of cornus pulp, 8-12 parts of astragalus membranaceus, 12-18 parts of salviae miltiorrhizae, 9-15 parts of safflower, 9-15 parts of ligusticum wallichii, 6-12 parts of bamboo shavings, 6-12 parts of rhizoma acori graminei, and 4-10 parts of liquorice. The Chinese patent medicine has the effects of invigorating qi and tonifying kidney, removing blood stasis and reducing phlegm, and restoring consciousness and inducing resuscitation, can be used for improving the clinical syndrome of a patient with vascular dementia, has an improving effect to traditional Chinese medicine score, cognitive competence, daily living activity and brain neurotransmitter of the patient with vascular dementia, has a total effective rate of 85.4 percent, is reliable in effect for treating vascular dementia, does not have remarkable toxic or side effect, and is high in bioavailability and good in controllability and stability.

This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been available.

This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been avai lable.

The invention discloses an application of BRSK2 to prepare antidiabetic drug in the biological medical domain, wherein the diabetes mellitus is a group of clinical syndrome interacted by genetic and environmental factor, which bases on hyperglycemia as main mark to lead the harm of multiple systems due to lingering illness; the BRSK2 can inhibit the function of insulin secretory as new antidiabetic drug and target, which provides a new approach and way to treat and test diabetes.

The invention relates to traditional Chinese medicine powder for treating type II diabetes mellitus of qi deficiency and blood stasis, and can effectively solve the medicine administration problem of preventing and treating hyperglycemia. The technical scheme for solving the problem is that the traditional Chinese medicine powder is formed by grinding and uniformly mixing the following components by weight: 25-35 g of corn silk, 25-35 g of kudzuvine root, 25-35 g of soybean meals, 18-22 g of Flos Sophorae, 9-11 g of mongolian dandelion herb, 50-70 g of yam, and 50-70 g of oat meal; all components support one another, and the remarkable function of reducing hyperglycemia is obtained; the traditional Chinese medicine powder can be used for effectively preventing and treating diabetes mellitus caused by hyperglycemia; as one of the clinical syndromes of hyperglycemia is thirst and high consumption of water, the traditional Chinese medicine powder can be effectively used for preventing thirst and excess water consumption for reducing hyperglycemia; therefore, the traditional Chinese medicine powder is also called thirst relieving and restoring powder, is an innovation of hypoglycemic agent, and has huge economical and social benefits.

The invention discloses a traditional Chinese medicine compound composition having an effect for treating heart failure as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from 10 to 30 parts of prepared radix astragali, 10 to 30 parts of lucid ganoderma, 10 to 30 parts of herba epimedii, 10 to 30 parts of cassia twig, 10 to 30 parts of radix salviae miltiorrhizae, 10 to 30 parts of flos abelmoschus manihot, 10 to 30 parts of herba leonuri, 10 to 30 parts of poria cocos, and 6 to 18 parts of dried orange peel. The traditional Chinese formula is selected according to the traditional Chinese medicine theory of treatment based on syndrome differentiation, and according to the disease mechanism of qi deficiency and blood stasis syndrome of the heart failure, the traditional Chinese medicine formula is scientific and reasonable and strict in herb selection, the clinical experiment result proves that the general treatment efficiency of the traditional compound composition provided by the invention reaches up to 87.5 percent, indexes of a patient such as clinical syndrome, living quality, LVEF, brain natriuretic peptide and the like can be obviously improved, and the effect for treating the heart failure is obvious. In addition, the traditional Chinese medicine composition provided by the invention is small in toxic and side effect and safe and reliable in medicine application.

Type 2 diabetes (T2D) is a clinical syndrome caused by insufficient insulin secretion for insulin requirements. described herein are compositions and methods for microphysiological MPS models of disease (MODs) for diabetes. These platforms allow one to compare the effect of chronic β-cell stimulation in the presence and absence of patient specific immune cells in IPSC-derived islets from each group. Additionally, one can reproduce the T2D β-cell phenotype, using islets-on-chips will also be exposed to gluco-lipotoxicity. Likewise, skeletal muscle-on-chips are exposed to patient specific activated immune cells, variable motor neuron innervation and lipids characteristic of T2D.

The invention relates to the field of protein engineering, gene engineering and biomedicine, and particularly relates to a DC cell-based hepatitis B virus T epitope peptide. According to the technical scheme, the DC cell-based hepatitis B virus T epitope peptide is characterized by consisting of 9 amino acid residues with an amino acid sequence of QLFHLCLII. According to the DC cell-based hepatitis B virus T epitope peptide, basic amino acid is used as a framework, a solid-phase synthesis technology is adopted, a same preset amino acid sequence is simultaneously synthesized on the framework; with the hepatitis B virus as a design target, and the DC cell-based hepatitis B virus specific epitope peptide is produced by adopting a synthesis technology; the epitope peptide is loaded in-vitro on the DC cell, the mature DC cell is infused into bodies of specific people, and generation of the specificity is capable of eliminating the hurt caused by hepatitis B virus infection and particularly cleaning viruses in the body and improving the clinical syndromes against acute hepatitis B.

The invention relates to the technical field of traditional Chinese medicine clinical data intelligent processing systems, in particular to a traditional Chinese medicine clinical syndrome diagnosis and treatment intelligent data processing and analysis mining system. A clinical database is used for storing data from a related traditional Chinese medicine data warehouse or automatically collected data; when a data model in a clinical database is from external input, inferior medical records are removed step by step in a data preprocessing module, abnormal data in medical record data are eliminated, and data of each attribute in a medical record data model is classified and summarized; a data analysis module performs contrast analysis on the data classified by the data preprocessing module and the data stored in the clinical database one by one so as to determine the rationality of each attribute data of the medical record data model, so that the compatibility and integration are extremely high when the clinical database is established and supplemented; and the diagnosis accuracy and efficiency can be improved in practical application.

The invention discloses a fructus lycii-red dates grain capable of replenishing qi and enriching the blood, and a preparation method thereof, relating to the technical field of traditional Chinese medicines. The fructus lycii-red dates grain contains the following raw materials in parts by weight: 27-40 parts of fructus lycii, 23-35 parts of red dates, 7-15 parts of concha ostreae, 15-25 parts offructus alpiniae oxyphyllae, 7-15 parts of fructus crataegi, 15-25 parts of poria, 7-15 parts of folium nelumbinis, 5-10 parts of baked ginger, 10-20 parts of fructus amomi villosi, 5-10 parts of semen nelumbinis, 0.1-0.5 parts of taurine, and 0.01-0.03 parts of vitamin B1. By carefully selecting Fructus Lycii, red dates, Concha Ostreae, fructus alpiniae oxyphyllae, Fructus Crataegi, Poria, FoliumNelumbinis, baked ginger, Fructus Amomi Villosi, Semen Nelumbinis and adding taurine and vitamin B1, all raw materials are complementary to coplay the efficacies of strengthening the spleen and stomach, tonifying qi and helping digestion, smoothing the nerves and resting to attain mental tranquility and benefiting the brain and reinforcing intelligence, the self immunity of infants can be enhanced, the health of spleen and stomach can be regulated, the clinical syndromes of the spleen and stomach such as diarrhea, abdominal distension, night sweat, spirit ennui, easiness in cold and illness and malnutrition can be effectively improved, the growth development of children can be promoted, the granular preparation has no toxic or side effect, is high in curing rate, and can be taken for a long time at ease.

The invention discloses a traditional Chinese medicine for treating an acquired immune deficiency syndrome and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine is prepared from, by weight, 3-5 parts of honeysuckle, 2-4 parts of costus roots, 3-5 parts of rhizoma coptidis, 4-7 parts of radix sophorae flavescentis, 4-5 parts of herba houttuyniae, 3-5 parts of radix sophorae subprostratae, 2-3 parts of herba fibraureae recisae, 3-5 parts of radix sileris, 3-5 parts of fructus schizandrae, 2-6 parts of cornus pulp, 2-5 parts of radix angelica sinensis, 3-4 parts of panax notoginseng, 3-5 parts of glossy ganoderma, 4-5 parts of radix astragali, 2-5 parts of cynomorium songaricum, 3-6 parts of liquorice, 4-7 parts of radix ranunculi ternate, 3-6 parts of herba agrimoniae, 6-8 parts f stems of noble dendrobium, 3-5 parts of fructus chebulae, 3-5 parts of gallnuts and 5-8 parts of spreading hedyotis herbs. The traditional Chinese medicine has the effects of clearing heat and removing toxicity, benefiting Qi and promoting blood circulation, strengthening the body resistance to eliminate pathogenic factors, nourishing Yin to strengthen the essence and the like and is suitable for treating multiple clinical syndromes in the type 1 acquired immune deficiency syndrome.

The invention provides a traditional Chinese medicinal composition for treating arrhythmia. The composition is prepared from the following traditional Chinese medicinal raw materials: radix sophorae flavescentis, dens draconis, cassia twig, radix curcuma, pubescent holly root, cinnabaris, fructus aurantii, curcuma phaeocaulis valeton, astragalus, scutellaria baicalensis, magnolia officinalis, typhae pollen, ligusticum, dandelion, radix aconite lateralis preparata, fleshfingered citron flower, allium macrostemon, folium isatidis, polygala tenuifolia, trogopterus dung, semen cuscutae, radix curcumae, poria cocos, fructus aurantii immaturus, poria with hostwood, sanders, radix aucklandiae, pericarpium citri reticulatae viride, malt and rhizoma sparganii. Based on the broad and profound traditional Chinese medical theory, the traditional Chinese medicinal composition is prepared by means of approval of repeated clinical tests, and has a good treatment effect on clinical syndromes of patients with arrhythmia. Furthermore, the traditional Chinese medicinal composition is convenient to prepare, has quick response after being taken, does not have toxic or side effect, does not have adverse response after being taken, and can play double roles in treatment and health-care on arrhythmia.

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating hypomenorrhea due postoperative intrauterine adhesion of qi stagnation and blood stasis type uterine cavities. The traditional Chinese medicine composition which is a traditional Chinese medicine comprises, by weight, 2-4 parts of armeniaca mume, 2-4 parts of prunus mume, 4-8 parts of Jordan almonds, 4-8 parts of aralia undulata, 4-8 parts of wild wampee leaves and roots, 4-8 parts of sterculia nobilis husk, 4-8 parts of herba alyxiae sinensis and 4-8 parts of radix glycyrrhizae. The traditional Chinese medicine composition has the advantages that various medicines are used with one another, and accordingly effects of soothing livers, relieving depression, promoting qi circulation and removing blood stasis can be jointly realized; the traditional Chinese medicine composition closely sticks to etiology and pathogenesis of the hypomenorrhea due to the intrauterine adhesion, accordingly, the menstrual blood volumes of patients can be obviously increased, and accompanying traditional Chinese medicine clinical syndromes can be improved.

The invention discloses a nucleic acid molecule and the application to prepare antidiabetic in the biological medical domain, wherein the diabetes mellitus is a group of clinical syndrome interacted by genetic and environmental factor, which bases on hyperglycemia as main mark to lead the harm of multiple systems due to lingering illness; the nucleic acid molecule SR2B2 is added into Langerhans' islet beta-cell to increase the content of insulin in the cell culture supernatant. The invention can accelerate the secretory function of insulin as new antidiabetic, which provides a new path and method to release and treat diabetes.

Angina pectoris is a clinical syndrome mainly manifesting paroxysmal chest pain or cheat discomfort caused by coronary artery insufficiency, myocardium sharp temporary ischemia or anoxia. Angina pectoris is characterized by prothorax paroxysmal and crushing pain, can be companied by other symptoms, namely, pain mainly positioned at the rear part of breastbone, can radiate to precardium and left upper extremity, and often happens during labor and rage. The drug is prepared by combining lycopus herb, Chinese trumpetcreeper, prepared rehmannia root, peach kernel, zedoary, rhizome of Sichuan lovage, radix paeoniae alba, red flower, burred tuber, frankincense, flatstem astragalus seed, achyranthes root, red sage root, bark of Chinese redbud, Chinese caterpillar fungus, faeces trogopterpri, giant knotweed, jasminum amplexicaule Buch, Chinese date, pangolin, leonurus heterophyllus, common myrrh tree, black sesame, dalbergia wood, caulis spatholobi, corydalis tuber, angelica sinensis, curcuma root, sappan caesalpinia, curcuma, atractylodes macrocephala, seed of cow-fat and herb of diverse wormwood, and the drugs are combined to ensure that efficacies of all the drugs generate a synergistic action, so that angina pectoris can be effectively treated.

The invention relates to the technical field of substitutional tea, and in particular discloses qi-supplementing and blood-nourishing tea and a preparation method thereof. The qi-supplementing and blood-nourishing tea comprises the following raw material compositions in parts by weight: 10-30 parts of Astragalus membranaceus, 15-30 parts of longan pulp, 5-10 parts of Codonopsis pilosula, 10-20 parts of cooking jujubes, 2-8 parts of medlar, 2-10 parts of caramel malt, 5-10 parts of pericarpium citri reticulatae, 2-5 parts of honey-fried licorice roots, 3-8 parts of lily, 2-5 parts of cordycepsflower, and 1-3 parts of black tea. According to the qi-supplementing and blood-nourishing tea and the preparation method thereof in the invention, due to scientific compatibility of medicines, the mutual synergy of various raw materials is sufficiently played; the qi-supplementing and blood-nourishing tea has the obvious therapeutic effect for the syndromes of qi deficiency, alimentary anemia andchronic fatigue, and is capable of obviously improving clinical syndromes and symptoms of sub-health patients with qi deficiency and blood deficiency; the qi-supplementing and blood-nourishing tea can realize qi nourishing, blood enriching and mild nourishing; the humoral immune function of patients suffering from choronic fatigue can be improved; and the physical vitality is recovered.

The invention discloses a nucleic acid molecule and the application to prepare antidiabetic in the biological medical domain, wherein the diabetes mellitus is a group of clinical syndrome interacted by genetic and environmental factor, which bases on hyperglycemia as main mark to lead the harm of multiple systems due to lingering illness; the nucleic acid molecule SR1B is added into Langerhans' islet beta-cell to increase the content of insulin in the cell culture supernatant. The invention can accelerate the secretory function of insulin as new antidiabetic, which provides a new path and method to release and treat diabetes.

The invention discloses a nucleic acid molecule and the application to prepare antidiabetic in the biological medical domain, wherein the diabetes mellitus is a group of clinical syndrome interacted by genetic and environmental factor, which bases on hyperglycemia as main mark to lead the harm of multiple systems due to lingering illness; the nucleic acid molecule SR3B2 is added into Langerhans' islet beta-cell to increase the content of insulin in the cell culture supernatant. The invention can accelerate the secretory function of insulin as new antidiabetic, which provides a new path and method to release and treat diabetes.

The invention discloses a nucleic acid molecule and the application to prepare antidiabetic in the biological medical domain, wherein the diabetes mellitus is a group of clinical syndrome interacted by genetic and environmental factor, which bases on hyperglycemia as main mark to lead the harm of multiple systems due to lingering illness; the nucleic acid molecule SR4B is added into Langerhans' islet beta-cell to increase the content of insulin in the cell culture supernatant. The invention can accelerate the secretory function of insulin as new antidiabetic, which provides a new path and method to release and treat diabetes.

The invention discloses a nucleic acid molecule and the application to prepare antidiabetic in the biological medical domain, wherein the diabetes mellitus is a group of clinical syndrome interacted by genetic and environmental factor, which bases on hyperglycemia as main mark to lead the harm of multiple systems due to lingering illness; the nucleic acid molecule SR1B2 is added into Langerhans' islet beta-cell to increase the content of insulin in the cell culture supernatant. The invention can accelerate the secretory function of insulin as new antidiabetic, which provides a new path and method to release and treat diabetes.

The invention discloses a nucleic acid molecule and the application to prepare antidiabetic in the biological medical domain, wherein the diabetes mellitus is a group of clinical syndrome interacted by genetic and environmental factor, which bases on hyperglycemia as main mark to lead the harm of multiple systems due to lingering illness; the nucleic acid molecule SR2B is added into Langerhans' islet beta-cell to increase the content of insulin in the cell culture supernatant. The invention can accelerate the secretory function of insulin as new antidiabetic, which provides a new path and method to release and treat diabetes.

The invention discloses a traditional Chinese medicine preparation for treating heart failure with preserved ejection fraction. The traditional Chinese medicine preparation is prepared from the following ten traditional Chinese medicines according to a certain proportion: radix ophiopogonis, fructus corni, rhizoma polygonati, rhizoma coptidis, snakegourd peel, earthworm, turtle shell, radix salviae miltiorrhizae, rhizoma pinelliae, fructus aurantii and the like. The traditional Chinese medicine preparation is mainly used for treating the heart failure with preserved ejection fraction, or heart failure and other diseases having clinical syndromes of yin deficiency with blood stasis with or without phlegm and fluid retention, and has the effects of nourishing yin, benefiting qi, activating blood, expelling phlegm and promoting urination. The traditional Chinese medicine preparation is precise and appropriate in medicine use, rigorous in compatibility of medicines and remarkable in curative effect; compared with simple western medicine intervention, the traditional Chinese medicine preparation has the advantages of further improving the clinical symptoms and psychological state of a patient who has the heart failure with preserved ejection fraction or the heart failure having clinical syndromes of yin deficiency with blood stasis with or without phlegm and fluid retention, improving quality of life, increasing exercise tolerance, reducing rehospitalization rate, and the like; furthermore, the traditional Chinese medicine preparation is safe to take and free from obvious toxic or side effects, and can be popularized and applied clinically.

The invention discloses a nucleic acid molecule and the application to prepare antidiabetic in the biological medical domain, wherein the diabetes mellitus is a group of clinical syndrome interacted by genetic and environmental factor, which bases on hyperglycemia as main mark to lead the harm of multiple systems due to lingering illness; the nucleic acid molecule SR5B2 is added into Langerhans' islet beta-cell to increase the content of insulin in the cell culture supernatant. The invention can accelerate the secretory function of insulin as new antidiabetic, which provides a new path and method to release and treat diabetes.

The invention discloses a traditional Chinese medicine preparation for treatment of liver and gallbladder damp-heat children lead poisoning. Various children lead poisoning syndromes are caused by lead evil accumulation in vivo to cause the characteristics of incoordination between the liver and the spleen, retention of damp-heat in the interior, weakness of the spleen and the stomach, lung spleen qi-deficiency, deficiency of liver-yin and kidney-yin and other common clinical syndromes, and the traditional Chinese medicine preparation is suitable for dehumidifying, detoxifying, strengthening spleen and promoting circulation by traditional Chinese medicine treatment based on syndrome differentiation. The traditional Chinese medicine preparation is prepared by decocting traditional Chinese medicines of veronicastrum stenostachyum, water primrose, adina rubella Hce, rorippa globosa, trema cannabina, root of swamp morningglory, cowpea, dioscorea hemsleyi, cicerbita cyanea(D. Don)Beauv, rex woodbetony, cassia mimosoides, primula malacoides and swertia punicea hemsl with water to obtain a decoction, and by clinical tests, the total effective rate is 95.5%, the curative effect is remarkable, and the traditional Chinese medicine preparation has no adverse reaction.

The invention discloses a traditional Chinese medicine for treating gallbladder cardiac syndrome and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw medicinal materials: radix bupleuri, astragalus, pollen typhae, dendrobe, longhairy antenoron herbs, polygonum cuspidatum, pericarpium citri reticulatae viride, cape jasmine fruit, oriental wormwoods, schisandra chinensis, wine-treated rhubarb, radix curcumae, rhizoma cyperi, roses, radix aucklandiae, hypericum japonicum, babysbreath, raw liquorice and donkey-hide gelatin. The traditional Chinese medicine disclosed by the invention is used for treating clinical syndromes including angina, arrhythmia, even myocardial infarction and other symptoms caused by biliary system diseases such as cholecystitis, cholelithiasis or cholangitis, and is easy to obtain materials, convenient to prepare, good in taste, easy to carry, remarkable in curative effect and free of toxic or side effects.