Application of traditional Chinese medicine composition in the preparation of drugs for the prevention and treatment of novel coronavirus combined with liver injury

A coronavirus and composition technology, applied in the field of medicine, can solve problems such as harm to the life and health of patients, and achieve the effects of improving the cure rate, improving clinical symptoms, and improving liver function.

Active Publication Date: 2022-04-12
雷允上药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective treatment drug for the new coronavirus SARS-CoV-2 on the market, which brings great harm to the life and health of patients

Method used

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  • Application of traditional Chinese medicine composition in the preparation of drugs for the prevention and treatment of novel coronavirus combined with liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of Chinese medicine compositions:

[0023] (1) The preparation method of the traditional Chinese medicine composition is: 833.3 parts by weight of the weight, 833.3 parts of Chunchanghu plus 10 times water, water vapor distillation for 2 hours, collect oil layers, distilled backhaul, and its dismissal residue 266.7 parts of the steric ginseng, 625 large green leaves, add 10 times of the medicinal material twice, 1 hour, combined with fried liquid and concentrate, add ethanol, filter, recover ethanol, add appropriate amount Water, refrigerated, filtered, extract;

[0024] (2) Take 333.3 parts of the large yellow, add 8 times the amount of water and cook twice, 1 hour, combined with fried liquid and concentrate, add ethanol, filter, recover ethanol, add appropriate amount of water, refrigerated, filtered, Combined with step (1) extract and concentrated, spray dry, plus step (1) volatile oil to obtain an extract of a Chinese medicine composition;

[0025] (3) The e...

Embodiment 2

[0026] Example 2 Traditional Chinese Medicine Compositions For ordinary coronaviruses HCOV-229E, 2019 new coronavirus SARS-COV-2 antiviral activity experiment

[0027] 1, experimental method

[0028] 1.1, Vero E6 cells (African green monkey renal cell line) toxicity test (MTT method)

[0029] The 96-well plate monolayer cell was washed once with PBS, abandoned, and 100 μl of 2 times gradient diluted Embodiment 1 of the pharmaceutical composition was extracted. White control group and normal cell group were added to equal volume culture solution, 34 ° C, 5% CO 2 Cultivate 2-5D under conditions. Subsequently, 20 μl of the MTT solution having a concentration of 5 mg / ml was then added to the incubation for 4 h. Abandoned, 100 μL of DMSO per well, oscillated at low speed for 5 min, allowing the crystal to fully melt. The absorbance value was determined on a 490 nM enzyme immune instrument, and the inhibition rate was calculated.

[0030] PRISM NON-Regression Analysis software calcula...

Embodiment 3

[0037] Example 3 Observation on the efficacy of anti-new coronavirus liver injury

[0038] 1, case choice:

[0039] 20 patients with new coronavirus (SARS-COV-2) were diagnosed (10 cases of men, women, aged 27 ~ 67 years old, with an average age of 51 ± 1.5 years), were detected by 2019-NCOV nucleic acid, 14 cases Symptom, 6 cases of light symptoms. 20 patients CT showed a double pulmonary pleurisulent glass shadow, a double lung texture thickened, and a large liver. Biochemical indicators show serum aminotransferase (Alt above 180u / L, AST above 210 u / L)) and bilirubin rises (higher than 60 μmol / L), lymphocytes, lymphocyte percentage is significantly lower than normal, blood oxygen Level 70 ~ 90%.

[0040] 2, treatment method:

[0041]20 cases were given to the basal Oxygen and vital signs Nutritional maintenance treatment, and the particulate agent obtained in Example 1 of the present invention was ok, and 2 bags (4g per bag) were ok, 3 times a day, 2 weeks per day, after 2...

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Abstract

The invention discloses the application of a traditional Chinese medicine composition in the preparation of medicines for preventing and treating novel coronavirus combined with liver damage. The present invention screens the intervention effect of the traditional Chinese medicine composition on the novel coronavirus (SARS-CoV-2), and the screening experiment shows that the traditional Chinese medicine composition provided by the present invention has a certain anti-new coronavirus (SARS-CoV-2) effect, and It can significantly reduce serum transaminase and bilirubin in patients with new coronavirus (SARS‑CoV‑2), improve liver function, and can assist in the treatment of new coronavirus and the liver damage caused by it, and can significantly improve clinical symptoms and increase the cure rate.

Description

Technical field [0001] The present invention relates to a Chinese medicine composition, and more particularly to the application of Chinese medicine compositions in the preparation of new coronaviruses and liver damage drugs, belonging to the field of medical technology. Background technique [0002] February 11th, International CommitteE On TaxOfviruses, ICTV declared the official name of the new coronavirus as a severe acute respiratory syndrome crosent virus 2 (SARS-COV-2). [0003] Symptoms of pneumonia infections caused by new coronaviruses, including general symptoms, severe symptoms, and dissemical symptoms, general symptoms are mainly fever, fatigue, dry cough, and gradually have difficulty breathing, and severe symptoms include coagulation dysfunction, difficult to correct Metabolic acidosis, sepsis, acute respiratory distress syndrome, non-typical symptoms, such as the psychosis, mental difference, nausea vomiting, diarrhea, etc., with nervous system symptoms If you hav...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/855A61K36/708A61P31/14A61P11/00A61P1/16
CPCA61K36/282A61K36/233A61K36/489A61K36/708A61K36/855A61K36/704A61K36/315A61K36/195A61P31/14A61P11/00A61P1/16A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 张丹丹王恒斌潘耀宗张邦国李全罗年翠曹泽庆翟云良
Owner 雷允上药业集团有限公司
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