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Traditional Chinese medicine preparation with functions of immunological regulation for anti-chemical damage

A technology of chemical liver injury and immune regulation, applied in the direction of medical preparations containing active ingredients, organic active ingredients, digestive system, etc., can solve problems such as serum transaminases that have not yet been seen

Active Publication Date: 2007-01-31
北京赛德维康医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological research has proved that Cordyceps polysaccharide can regulate immunity, lower blood sugar, and anti-tumor, but there is no literature report on the anti-alcohol-induced acute liver injury and the corresponding increase of serum transaminase caused by Cordyceps polysaccharide

Method used

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  • Traditional Chinese medicine preparation with functions of immunological regulation for anti-chemical damage
  • Traditional Chinese medicine preparation with functions of immunological regulation for anti-chemical damage
  • Traditional Chinese medicine preparation with functions of immunological regulation for anti-chemical damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 8kg of Ganoderma lucidum, crush it, add 10 times the amount of hot water to reflux for leaching for 2 hours, filter, and re-extract the filter residue once in the same way, combine the filtrate, control the temperature at 50°C and concentrate under reduced pressure, add 95% ethanol to the concentrate Precipitate overnight, add deionized water to redissolve the precipitate, add 95% ethanol to precipitate for 12 hours, dry under reduced pressure to obtain Ganoderma lucidum extract powder, pulverize, and pass through a 100-mesh sieve to obtain Ganoderma lucidum extract. The polysaccharide content of Ganoderma lucidum in the extract is 35% by the sulfuric acid-anthrone method.

Embodiment 2

[0035] Cordyceps sinensis was inoculated into the fermentation bottle according to the inoculation amount of 10%, and the composition of the fermentation liquid was white sugar 4.0%, soybean powder 1.0%, yeast powder 0.42%, KH 2 PO 4 0.5%, MgSO 4 ·7H 2 O 0.075%, centrifuged after 120 hours of fermentation at 28°C, collected the fermented liquid for subsequent use, added 10 times the amount of deionized water to the mycelia, soaked at 95°C for 5 hours, filtered, added 5 times the amount of deionized water to the filtrate, and added 95 Soak for 5 hours at ℃, filter. Combine the centrifuged supernatant and mycelium of the fermentation broth and soak the filtrate twice, concentrate under reduced pressure at 50°C to one-third of the original volume, add 95% ethanol to precipitate overnight, and redissolve the precipitate with 2 times the amount of deionized water , adding 95% ethanol to precipitate for 12 hours, drying under reduced pressure to obtain Cordyceps extract powder, ...

Embodiment 3

[0037] Prepare 1000 compound Chinese medicine capsules: get respectively 135 grams of Ganoderma lucidum extract obtained by the method of Example 1, and 135 grams of Cordyceps extract obtained by the method of Example 2, with a total weight of 270 grams, (by Ganoderma lucidum polysaccharide in the compound recipe) 50%, the proportion of Cordyceps polysaccharide 50%), mixed evenly, and filled into 1000 capsules.

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PUM

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Abstract

A Chinese medicine with immune regulation function for treating alcoholic liver cell injury and relative hyper-serum-transaminase contains ganoderic polyose and cordycepic polyose.

Description

technical field [0001] The invention relates to a health care product and a traditional Chinese medicine oral preparation, in particular to a health care product or a traditional Chinese medicine oral preparation with immune regulation function for preventing and treating chemical liver damage and a preparation method thereof. Background technique [0002] The B-ultrasound detection rate of fatty liver among ordinary adults in some European and American countries has reached 20%, and in economically developed cities such as Shanghai and Beijing in my country, it has also reached more than 10%, and it is on the rise year by year. Among them, alcohol-induced chemical liver damage accounts for about 50% of fatty liver patients. Alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis often occur successively or simultaneously; regardless of the severity of ultrastructural changes in liver tissue, there are varying degrees of abnormal liver function and elevated serum...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K36/074A61P1/16
Inventor 汪海王倩马燕于海涛石永平
Owner 北京赛德维康医药研究院
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