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Crocodile shell extract for treating hepatic fibrosis and application of crocodile shell extract

A liver fibrosis and extract technology is applied in the field of traditional Chinese medicine extracts for the treatment of liver fibrosis, and can solve the problems that have not yet been seen.

Inactive Publication Date: 2015-07-29
许瑞安
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there have been no related reports on the research results of treating liver fibrosis with crocodile shell as a raw material.

Method used

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  • Crocodile shell extract for treating hepatic fibrosis and application of crocodile shell extract
  • Crocodile shell extract for treating hepatic fibrosis and application of crocodile shell extract
  • Crocodile shell extract for treating hepatic fibrosis and application of crocodile shell extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] "Example 1" preparation of crocodile shell extract

[0035] Take 500g of Chinese herbal medicine crocodile carapace, soak in 5kg of water for 1 hour, decoct for 1 hour, filter, store the filtrate in another container, add 4kg of water to the dregs, decoct for 1 hour, filter, combine the filtrate with the previous filtrate, and reduce the temperature at 60°C. The filtrate was distilled under pressure, concentrated to a thick paste with a specific gravity of 1.20, and freeze-dried to obtain the crocodile shell extract.

Embodiment 2

[0036] "Example 2" preparation of crocodile shell extract

[0037] Take 1000g of Chinese herbal medicine crocodile carapace, soak in 10kg of water for 1 hour, decoct for 1 hour, filter, store the filtrate in another container, add 8kg of water to the dregs, decoct for 1 hour, filter, combine the filtrate with the previous filtrate, and reduce the temperature at 65°C. The filtrate was distilled under pressure, concentrated to a thick paste with a specific gravity of 1.20, and freeze-dried to obtain the crocodile shell extract.

Embodiment 3

[0038] "Example 3" Construction and Preparation of Animal Models

[0039] 60 mice were divided into 6 groups: normal group, model group, low-dose crocodile shell extract group, medium-dose crocodile shell extract group, high-dose crocodile shell extract group, and positive drug silymarin group. The normal group was injected with corn oil, and the other groups were injected with 25% CCl 41mL / 100g body weight intraperitoneal injection, twice a week, for eight consecutive weeks, to complete the establishment of carbon tetrachloride-induced liver fibrosis mouse model.

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Abstract

The invention discloses a crocodile shell extract for treating hepatic fibrosis and application of the crocodile shell extract. The extract is the crocodile shell extract which is prepared by boiling crocodile shells with water, and by extracting, concentrating and drying the liquid. The pharmacodynamic experiment shows that the extract has the effects of reducing serum transaminase of hepatic fibrosis model mice and the deposition degree of liver collagen fiber of the mice, improving liver inflammation and fibrosis pathology change of the mice, preventing and treating liver fibrosis pathology change, and delaying development of chronic liver diseases to liver cirrhosis, and has the potential to be used for developing and preparing medicines for preventing and treating hepatic fibrosis.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine extract for treating liver fibrosis and application thereof. Background technique: [0002] Hepatic fibrosis (HF) is an abnormal hyperplasia of connective tissue in the liver caused by various chronic pathogenic factors (inflammation, alcohol, parasites, poisoning, metabolic disorders, blood circulation disorders, nutritional disorders, etc.) ECM (extea cellular matrix) is a common pathological process of excessive deposition of extracellular matrix, and pathogenic factors cause oxidative stress in the liver and the production of cytokines is the initiating link of liver fibrosis. Hepatic fibrosis is an early and necessary stage in the development of chronic liver disease to cirrhosis, which can be reversed under certain circumstances. However, if the cause persists, liver fibrosis will gradually increase, liver lobules and blood vessels w...

Claims

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Application Information

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IPC IPC(8): A61K35/58A61P1/16
Inventor 许瑞安朱亚玲崔秀灵
Owner 许瑞安
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