60 results about "Pulmonary blood vessel" patented technology

A lesion area detection unit detects an abnormal peripheral structure (lesion area), a pulmonary blood vessel extraction unit extracts a branch structure (pulmonary blood vessel) from the three-dimensional medical image, an associated blood vessel identification unit identifies an associated branch structure functionally associated with the abnormal peripheral structure based on position information of each point in the extracted branch structure, and an associated lung parenchymal area identification unit identifies an associated peripheral area (lung parenchyma) functionally associated with the identified associated branch structure based on the position information of each point in the extracted branch structure.

Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and / or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and / or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.

A lesion area detection unit detects an abnormal peripheral structure (lesion area), a pulmonary blood vessel extraction unit extracts a branch structure (pulmonary blood vessel) from the three-dimensional medical image, an associated blood vessel identification unit identifies an associated branch structure functionally associated with the abnormal peripheral structure based on position information of each point in the extracted branch structure, and an associated lung parenchymal area identification unit identifies an associated peripheral area (lung parenchyma) functionally associated with the identified associated branch structure based on the position information of each point in the extracted branch structure.

The present invention discloses a method and device for extracting pulmonary blood vessels from pectoral CT (computed tomography) images. The method includes the following steps that: n layers of inputted pectoral CT images are received, a designated image layer is obtained and is subjected to gray-scale mapping, so that a preset segmentation threshold value can be obtained; designated pixel points of a lung region are selected from the designated image layer, so that initial seed points can be obtained, 3D regional growth is performed according to the preset segmentation threshold value and the initial seed points, and a lung tissue region without blood vessels is obtained; morphological operation is performed on the lung tissue region, so that a closed lung tissue region with blood vessels is obtained, and a blood vessel threshold value is calculated; pixel points larger than the blood vessel threshold value are searched in the closed lung tissue region with blood vessels, and the pixel points are adopted as initial mark points, and an initial diffusion surface is obtained; and surface diffusion is performed in the closed lung tissue region with blood vessels according to the initial diffusion surface and the blood vessel threshold value, so that pulmonary blood vessels can be obtained. With the method and device of the invention adopted, the pulmonary blood vessels can be accurately extracted from the pectoral CT images, and therefore, doctors can be assisted to diagnose pulmonary vascular disease accurately.

This invention relates to the discovery that midkine modulates pulmonary vasculature development and smooth muscle cell development. Modulation of midkine activity thus alters pulmonary vasculature development and smooth muscle cell development. The invention provides methods of modulating pulmonary disorders, smooth muscle cell related disorders, and pulmonary smooth muscle cell disorders. Disorders of particular interest include, but are not limited to, asthma and pulmonary hyperplasia. Further the invention relates to the discovery that TTF1 and HIF1 -α exhibit midkine modulating activity. The invention pertains to the discovery that midkine modulates myocardin activity.

The invention relates to a Chinese medicinal composition for treating broiler abdominal dropsy and a preparation method thereof. The Chinese medicinal composition is characterized by consisting of the following medicaments in part by weight: 48 to 52 parts of root of red-rooted salvia, 28 to 32 parts of szechuan lovage rhizome and 18 to 22 parts of tuckahoe. The preparation method comprises the following steps of: weighing the root of red-rooted salvia, the szechuan lovage rhizome and the tuckahoe serving as raw materials according to the weight ratio; crushing and screening to ensure that the particle diameter is between 60 and 200 meshes; and sub-packaging to obtain the finished product. The Chinese medicinal composition has the advantages that: the szechuan lovage rhizome and the root of red-rooted salvia in the prescription are common medicaments for activating blood circulation to dissipate blood stasis according to etiology and pathogenesis of the broiler abdominal dropsy; the modern pharmacological researches show that the szechuan lovage rhizome can relax lung blood vessels and reduce pulmonary artery pressure; and the root of red-rooted salvia and the szechuan lovage rhizome can also expand coronary vessels and increase blood supply of heart so as to obviously improve the function of the heart. By the method, the occurrence rate of the broiler abdominal dropsy can be greatly reduced in outdoor expansion tests under natural conditions.

The present invention provides compositions and methods of using microRNAs to treat pulmonary arterial hypertension. In one aspect, methods are disclosed that are useful for identifying a subject in need of therapeutic intervention to reduce or improve a symptom of pulmonary arterial hypertension, reducing proliferation of pulmonary vascular cells in a subject, or treating pulmonary arterial hypertension in a subject. In another aspect, compositions include an inhibitor of fibroblast growth factor 2 (FGF2) expression comprising at least one of: a mature sequence of miR-424 or miR-503; a pri-miRNA of miR-424 or miR-503; a pre-miRNA of miR-424 or miR-503; and the complement thereof. Pharmaceutical compositions for reducing proliferation of pulmonary vascular cells in a subject in need thereof and biomarker panels are also disclosed.

The invention discloses a pure traditional Chinese medicine preparation for treating childhood asthma and a preparation method thereof. The pure traditional Chinese medicine preparation comprises the following Chinese medicine components: 8-12 g of astragalus membranaceus, 3-9 g of rhizoma atractylodis macrocephalae, 0.5-2 g of radices sileris, 11-18 g of poria cocos, 12-19 g of liquorice, 3-7 g of pinellia ternate, 2-9 g of vermilion, and 38-50 ml of a folium ginkgo extracting solution. The invention also discloses the preparation method of the pure traditional Chinese medicine preparation. The effective components of the pure traditional Chinese medicine preparation can be directly acted on the focus to expand the vasa publica; the medicine effect is directly acted on the deep layer of the respiratory tract to repair the mucosa and gradually decompose the sputum of each part; the sputum can be cleared and removed simultaneously to prevent accumulation and deposition of the sputum; the lung and the airways are kept from the sputum for a long time.

The invention discloses a trigger type high-frequency jet ventilator used for cardio-pulmonary resuscitation. The trigger type high-frequency jet ventilator comprises an equipment body, wherein the equipment body comprises a power supply system, a control module, a humidification system, a respiration module and a perception module, wherein the control module comprises a processor, a data collection module, a display module and a solenoid valve control module. The equipment body, the power supply system, the control module, the humidification system, the respiration module and the perception module are cooperated and can replace a traditional respirator or artificial assistance aeration, uninterrupted air injection is provided for the human body, patient oxygenation during cardiopulmonaryresuscitation is effectively improved, a rescue success rate is increased, and complications can be reduced. When external chest compression is carried out, effective aeration during a thorax springback period is guaranteed, pulmonary blood can be accelerated to flow back to the heart since pulmonary blood vessels are extruded, a heart blood returning amount is increased, blood circulation under the external chest compression is accelerated, the trigger type high-frequency jet ventilator can be used in an outdoor area without alternating current, and a patient in the open air can be rescued intime.

A method employing pattern recognition techniques for identifying the functional status of patients with Pulmonary Hypertension is described. This method describes a process by which sets of cardiopulmonary exercise gas exchange variables are measured during rest, exercise and recovery and stored as unique data sets. The data sets are then analyzed by a series of feature extraction steps, yielding a multi-parametric index (MPIPH) which reflects the current functional status of a patient. The method also employs a description scheme that provides a graphical image that juxtaposes the measured value of MPI to a reference classification system. An additional description scheme provides a trend plot of MPI values measured on a patient over time to provide feedback to the physician on the efficacy of therapy provided to the patient. The method will enable physicians to gather, view, and track complicated data using well-understood visualization techniques to better understand the consequences of their therapeutic actions.

The invention discloses immunoliposome based on endostatin genes, a preparation method and the application thereof. The immunoliposome comprises Vasohibin gene recombination eukaryotic expression vector, liposome and anti-eighth factor-associated antigen monoclonal antibody; wherein the liposome internally wraps up the Vasohibin gene recombination eukaryotic expression vector; the surface of the liposome is connected with the anti-eighth factor-associated antigen monoclonal antibody; the preparation method thereof comprises three steps of: the construction of the Vasohibin gene recombination eukaryotic expression vector, the preparation of the liposome wrapping up the Vasohibin gene recombination eukaryotic expression vector, and the connection of the liposome wrapping up the Vasohibin gene recombination eukaryotic expression vector and the anti-eighth factor-associated antigen monoclonal antibody. The immunoliposome can particularly act on vascular endothelial cells of the lung to inhibit the vasculogenesis and pulmonary fibrosis formation, has strong targeting effect, little side effect and can be used for preparing anti-fibrosis drugs.

The invention relates to the field of pharmaceutical chemistry and particularly provides a polydatin (PD) derivative containing a NO (nitric oxide) donor. A PD (3,4',5-trihydroxystilbene-3-beta-D-glucoside)4' hydroxyl group and a corresponding nitrate ester are subjected to chemical reaction so as to generate the NO donor type PD derivative which is in ester bond connection. After being absorbed into a lung tissue, the compound is subjected to biological transformation and ester bond breakage so that a bulk pharmaceutical chemical PD and the NO donor are dissociated, the NO donor can release NO slowly, and NO and PD can play roles of reducing pulmonary hypertension, relieving right ventricular hypertrophy, improving the pulmonary vascular endothelium function and resisting lipid peroxide cooperatively. The NO donor type PD derivative has an application in the aspect of preparing medicaments for preventing or treating pulmonary hypertension and high altitude pulmonary edema diseases caused by oxygen deficiency.

The invention relates to a new use of a drug, and specifically relates to an effect of atorvastatin on preparation of a drug for treating pulmonary hypertension. The invention discovers for the first time that atorvastatin is capable of alleviating MCT (Monocrotaline)-induced pulmonary inflammation, and inhibiting pulmonary vascular remodeling, pulmonary artery rising and right ventricular hypertrophy without affecting the body circulating pressure; NF-kB is possible to play an important role in the MCT-induced pulmonary hypertension; the atorvastatin is capable of inhibiting the inflammatory reaction by reducing the expression of the MCT-induced pulmonary hypertension lung tissue NF-kB, and is capable of reducing pulmonary vascular remodeling and inhibiting the pulmonary artery high pressure rising; therefore, the atorvastatin can be applied to preparation of the drug for treating the pulmonary hypertension.

The invention discloses a pulmonary vessel classification method and device, a computer readable storage medium and electronic equipment, and relates to the technical field of image processing. The lung blood vessel classification method comprises the following steps: determining bronchial segmentation information corresponding to a lung image to be classified; and determining first lung vessel classification information corresponding to the to-be-classified lung image based on the bronchial segmentation information. The pulmonary artery blood vessel information in the to-be-classified lung image is determined through the bronchial segmentation information by using the concomitant relationship between the pulmonary artery blood vessel and the bronchial tube, and classification of the pulmonary artery blood vessel and the pulmonary vein blood vessel is realized, that is, the first pulmonary blood vessel classification information is determined. Since the pulmonary blood vessel classification refers to the distribution information of the bronchus having an accompanying relationship with the pulmonary artery blood vessel, the pulmonary artery blood vessel can be determined more accurately and quickly, and the accuracy and efficiency of pulmonary blood vessel classification are improved.

The invention relates to a chest CT image processing method and device. The method comprises the steps: S01, carrying out segmentation processing of a to-be-processed chest image through a trained Unet++ model, and obtaining a first image of a pulmonary parenchyma region; and S02, performing segmentation processing on the first image by using a trained nnUnet model to obtain an image segmentation result of a pulmonary vessel region. Compared with the prior art, the method has the advantages that a full-automatic method for accurately and objectively separating pulmonary blood vessels based on conventional CT image analysis can be provided, the pulmonary blood vessels are accurately extracted, and finer diagnosis information is provided for doctors when doctors diagnose lung diseases.

The invention provides a lung artery and vein extraction method based on a CT image. The method comprises the following steps: acquiring a lung CT image to be segmented; establishing N targets to be segmented on the lung CT image; setting a preset target threshold value and a plurality of first seed points for each target; according to the first seed point and the target threshold value, synchronous growth operation is carried out to extract lung trunk blood vessels; extracting intrapulmonary blood vessels from the lung CT image; and connecting the lung trunk blood vessel with the intra-pulmonary blood vessel. The invention further provides a lung artery and vein extraction device based on the CT image and electronic equipment. Therefore, the lung artery and vein blood vessels can be segmented more accurately, and more accurate diagnosis and treatment information can be provided for doctors.

The invention discloses a preparation method and application of an RNA interfering medicine for treating a pulmonary hypertension syndrome and an efficacy validation method thereof. The preparation method comprises the following steps: firstly, establishing a slow virus expression vector, namely HIF-1alpha-shRNAi; secondly, packaging HIF-1alpha-shRNAi recombinant plasmids into a preparation; thirdly, injecting the plasmids into bodies of broilers, silencing an HIF-1alpha gene, inhibiting expressions of a vascular endothelial growth factor (VEGF), endothelin 1 (ET 1) and an insulin-like growth factor II (IGF - II) of a downstream gene and the like, controlling a pulmonary vascular remodeling (PVR) phenomenon, reducing damage of a cardiopulmonary function and ascites formation and finally achieving the clinical treatment to the pulmonary hypertension syndrome. The preparation method has the advantages of specificity, high efficiency and multifunctionality and the like on an aspect of treatment.

An aminoadamantane nitrate compound represented by formula (I) or a pharmaceutically acceptable salt thereof is disclosed for use in preparing a drug for preventing and / or treating lung diseases. Theaminoadamantane nitrate compound represented by the formula (I) or pharmaceutically acceptable salts thereof can both inhibit NMDA receptor over-activation by non-competitive binding to NMDA receptorchannels and inhibit NMDA receptor over-activation by non-competitive binding, Play anti-inflammatory and antioxidant role, but also targeted pulmonary vascular NMDA receptor release of nitric oxide,dilate pulmonary blood vessels, improve pulmonary circulation and reduce pulmonary hypertension. As such, these compounds can be used as drug for that prevention and / or treatment of lung diseases, including acute lung injury, asthma and chronic obstructive pulmonary disease, and can be combined with existing drugs to form various dosage forms with available drug carriers.

The invention relates to a method for producing an NO / N2 gaseous mixture, comprising the steps of effecting a purification of impure gaseous nitrogen containing impurities at least of the O2 type by putting the impure nitrogen in contact with a catalyst and then with a molecular sieve; mixing the pure nitrogen obtained with nitric oxide (NO), and obtaining a mixture formed from NO and pure nitrogen containing an NO content of less than 20% by volume and a proportion of impurities of the O2 type of less than 5 ppmv and of the H2O type of less than 40 ppmv. The NO / nitrogen mixture may undergo supplementary dilutions with pure nitrogen. Such NO / nitrogen mixtures can be used for treating, by inhalation, pulmonary vasoconstrictions in adults or children, in particular in new-born babies suffering from primitive pulmonary hypertension or in patients undergoing heart surgery.

The embodiment of the invention relates to a lung artery and vein segmentation method and device for a CT image, a medium and electronic equipment, and the method comprises the steps: carrying out the preprocessing of a chest CT image obtained in advance, and obtaining a lung region range in the chest CT image; performing multi-plane reconstruction based on the chest CT image, and performing segmentation through a threshold segmentation method in the reconstruction process to obtain a pulmonary blood vessel image; carrying out image segmentation on the pulmonary blood vessel image through a region growing method to obtain a pulmonary artery image and a to-be-segmented vein image which does not contain arteries; performing image segmentation on the vein image to be segmented through a region growing method to obtain a pulmonary vein image; and based on the lung region range, carrying out image segmentation on the pulmonary artery image and the pulmonary vein image to obtain the pulmonary artery image and the pulmonary vein image. According to the lung artery and vein segmentation method, the segmentation result is high in accuracy, and the clinical application requirement can be met.

The invention provides a method and device for segmented positioning of a pulmonary blood vessel, equipment and a storage medium, and the method comprises the steps: segmenting and extracting a maximum external cubic region of a three-dimensional image where a target lung blood vessel is located from an obtained lung three-dimensional image, and taking the maximum external cubic area as first input data; inputting the first input data into a trained pulmonary blood vessel segmentation positioning model to obtain a first segmentation result, a second segmentation result and an initial positioning result of the target pulmonary blood vessel; determining a positioning candidate area corresponding to each blood vessel branch of the target pulmonary blood vessel by using the first segmentation result and the second segmentation result; and for each blood vessel branch of the target pulmonary blood vessel, correcting a starting point coordinate corresponding to the blood vessel branch in the initial positioning result by using the positioning candidate area corresponding to the blood vessel branch to obtain a final positioning result of the target pulmonary blood vessel. Segmented positioning can be conducted on the target pulmonary blood vessel, and the accuracy of the segmented positioning result is improved.

The invention relates to an augmented reality auxiliary operation method, comprising the following steps: 101, obtaining lung CT image data of a patient; 102, using region growth and image filling algorithm to process the acquired lung CT image data to obtain pulmonary blood vessel data and tracheal data; 103, according to the data of pulmonary vessels and trachea, constructing the edge mesh model; 104, and importing the edge mesh model into the hybrid reality device for display for doctors to observe. The augmented reality assisted surgical method provided by the invention can realize the display of the lung tissue structure of a patient on a mixed reality device, and is more stereoscopic and clear compared with the traditional PC terminal result display.

A method for vascular regeneration comprises delivering endothelial cells to a lung scaffold, delivering perivascular cells to the lung scaffold, and providing a multiphase culture program to the scaffold. The multiphase culture program comprises a first phase including delivering an angiogenic medium, e.g., having 40-100 ng / ml of pro-angiogenic factors, and a second phase including delivering a stabilization medium, e.g., having 0.5-2% of serum and 1-20 ng / ml of angiogenic factors.

This invention is referred to the field of medicine, namely preventative treatment, and may be used as a means of synergetic minimization of negative impact of flights on human health (brain, stomach, lungs, blood vessels, heart etc.) with application of known substances and medicines with newly discovered pharmacological properties in new conditions. The ultimate technical solution of this invention would be synergetic minimization of negative impact of flying on human health without foot swelling, belching, jet-lag, tiredness and fatigue etc. The claimed technical result is achieved by the method of synergetic minimization of negative impact of air flights on human health, including consumption of substances that improve osmotic concentration of blood plasma, in the form of oral rehydration solution, split into two intakes as a minimum, first intake in the amount of at least 0.3 liters up to 1 liter before boarding and further during the flight from half an hour to 2 hours at least 0.3 liters to 1 liter and on as-needed basis.

The invention provides a pulmonary vessel segmentation method and device, a storage medium and electronic equipment, and relates to the technical field of image processing. The pulmonary blood vessel segmentation method comprises the following steps: processing a to-be-segmented lung three-dimensional image, a first pulmonary blood vessel segmentation image corresponding to the to-be-segmented lung three-dimensional image and a mediastinal mask image corresponding to the first pulmonary blood vessel segmentation image by using a pulmonary blood vessel mediastinal optimization model; generating a first mediastinal vessel segmentation image, a first initial pixel fusion weight matrix corresponding to the first pulmonary vessel segmentation image, and a second initial pixel fusion weight matrix corresponding to the first mediastinal vessel segmentation image; and generating a second lung blood vessel segmentation image corresponding to the to-be-segmented lung three-dimensional image based on the first lung blood vessel segmentation image, the first mediastinal blood vessel segmentation image, the first initial pixel fusion weight matrix and the second initial pixel fusion weight matrix. According to the pulmonary blood vessel segmentation method, the segmentation result of the mediastinal septum is more accurate, so that a doctor can conveniently diagnose lung-related diseases of a patient.

The present invention relates to agonists of Neprilysin and their use in preventing and treating pulmonary vascular remodeling. Also described are diagnostic and screening applications stemming from the inventor's discovery that Neprilysin is expressed at reduced levels in disease tissues.

The invention belongs to the field of medicinal chemistry and provides an application of ciglitazone in preparing drugs for treating pulmonary arterial hypertension. An experiment of the invention proves that ciglitazone is capable of effectively reducing average pulmonary artery pressure and pulmonary vasculature resistance of pulmonary arterial hypertension rats, increasing cardiac output, reducing right ventricular hypertrophy index, improving pulmonary vasculature remodeling and increasing protein expression of Gamma(peroxisome proliferation activated receptor, PPAR Gamma). The experimentproves that ciglitazone has a therapeutic effect on pulmonary arterial hypertension.

The invention discloses a clinical exercise device for cardiovascular medicine, which includes a connecting belt, a ferrule, a strap, a rotating plate, a torsion spring, a placement sleeve, a mounting plate, a motor, a rotating shaft, and a cam. The clinical exercise device for cardiovascular medicine has an ingenious structure , powerful, easy to operate, by using this device, not only can exercise the upper limbs of the patient, but also can expand the chest of the patient, so as to stretch the patient's heart and lung blood vessels, improve the ability of the heart and lung to supply blood oxygen, thereby improving Cardiopulmonary function greatly improves the recovery progress of patients.

The present invention discloses a long-chain non-coding RNA for screening hepatopulmonary syndrome (HPS) and an application of the long-chain non-coding RNA. A nucleotide sequence of the long-chain non-coding RNA is shown as SEQ ID NO.1. lncRNA is synthesized in large amounts in liver of patients with HPS and secreted into the lung through blood in an exosome manner, induces pulmonary inflammationand pulmonary microangiogenesis, thus affects pulmonary vasodilation and leads to the patients with typical HPS symptoms of breathing difficulties, etc. Therefore, by detecting amount of the lncRNA in blood exosomes of the patients, the long-chain non-coding RNA can be used for clinically and efficiently screening out the HPS patients.

The invention provides a medical image processing method and device, a medium and electronic equipment. The medical image processing method comprises the following steps: acquiring a lung medical image of a patient; acquiring a lung vessel model of the patient according to the lung medical image of the patient; classifying the mediastinal region blood vessels into mediastinal region pulmonary artery blood vessels and mediastinal region pulmonary vein blood vessels; classifying the first intra-pulmonary blood vessels into first artery blood vessels and first vein blood vessels according to the communication relationship between the first intra-pulmonary blood vessels and the mediastinal region pulmonary artery blood vessels and the mediastinal region pulmonary vein blood vessels; classifying the second intra-pulmonary blood vessels into second artery blood vessels and second vein blood vessels according to the positions and shapes of the second intra-pulmonary blood vessels; according to the first artery blood vessel and the second artery blood vessel, obtaining an intra-pulmonary artery blood vessel, and according to the first vein blood vessel and the second vein blood vessel, obtaining an intra-pulmonary vein blood vessel. The medical image processing method can accurately distinguish the vein and the artery in the lung medical image.