185 results about "Preventative treatment" patented technology

The present invention intended to provide an agent for preventing / treating Alzheimer's disease. More specifically, the present invention provides an agent for preventing / treating Alzheimer's disease, etc., which comprises a monoclonal antibody specifically reacting with a partial peptide at the C-terminal region of a β-amyloid or its derivatives.

The incorporation of one or more therapeutic agents on metallic and non-metallic medical prostheses is provided. The therapeutic agent can be used, for example, to prevent, treat, or reduce bacterial and fungal infections associated with these implants. Additionally, the therapeutic agents can be used to effect other therapeutic benefits. Specifically, a bilayer therapeutic coating is applied in two steps. Additionally, non-antimicrobial therapeutic agents may be incorporated in this coating to treat, prevent, modify, or stimulate certain clinical bioactivities.

The present invention provides 4-(3-Amino-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamines of formula Ihaving BACE1 and / or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and / or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

Composition and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of liver related disease, inflammatory disease and related conditions are disclosed. Also provided are kits and reagents for prognosis and diagnosis of liver related disease, inflammatory disease and related conditions.

This invention provides for transgenic non-human mammalian models of human disease, methods of making such models as well as methods of using such models to assess efficacy of therapeutic and prophylaxis treatments, to assess the antigenic potential of compounds, and other uses.

A preventive / therapeutic composition for free radical diseases, characterized by containing as an active ingredient at least one of a fullerene, a fullerene derivative, and a composite comprising a fullerene or fullerene derivative and an organic compound with which the fullerene or derivative has been modified or clathrated. The composition is reduced in side effects, has the high ability to eliminate free radicals in the body, and further has excellent preparation stability.

Disclosed are methods of preventing, treating, or diagnosing in a subject a disorder in protein folding or aggregation, or amyloid formation, deposition, accumulation, or persistence consisting of administering to said subject a pharmaceutically effective amount of inositol stereoisomers, enantiomers or derivatives thereof.

The present invention relates to methods for the induction and a cell to enter the Islet 1+ (Isl1+) lineage and methods for expansion of cells of islet 1+ lineage. One aspect of the present invention relates to methods to induce a cell to enter the islet 1+ lineage, and more particularly to a method to induce a cell to enter a the Isl1+ lineage to become an Isl1+ progenitor that is capable of differentiating along multiple different lineages such as a endothelial lineage, a smooth muscle lineage or a cardiac lineage. In particular, one embodiment present invention relates to methods to induce a cell to enter the Isl1+ lineage by inhibiting a wnt signalling pathway in the cell. Another aspect of the present invention relates to methods to expand a cell of the Isl1+ lineage, such as a Isl1+ progenitor by activating a wnt signalling pathway in the Isl1+ progenitor. Another aspect of the present invention relates to use of cells of the isl1+ lineage in subjects for therapeutic and preventative treatment of cardiovascular diseases.

The present invention relates to the use of proboscis in nutritional compositions or medicaments for the prevention of treatment of gut-neuromuscular abnormalities. Such abnormalities are, for example, associated with colic in babies, gut-pain or gut discomfort in general. In particular, the invention relates to the prevention or treatment of gut neuromuscular abnormalities after infection. Proboscis may be administered in a living or dead state, and also supernatant of fermentation medium may be directly used to achieve the beneficial effects reported herein.

The invention relates to a Chinese medicinal feed additive for preventing and treating common diseases of chickens. The Chinese medicinal feed additive is prepared from the following selected raw materials according to parts by weight: radix scutellariae, rhizoma coptidis, golden cypress, milk veteh, fructus forsythiae, honeysuckle, rhizoma belamcandae, rhizoma atractylodis, fried bighead atractylodes rhizome, hawthorn, barley malt, medicated leaven, codonopsis pilosula and liquorice. A preparation method of the Chinese medicinal feed additive comprises the steps of mixing and then grinding the raw materials, or respectively grinding and then mixing the raw materials. The feed additive has the effects of strengthening body immunity to eliminate pathogenic factors, clearing away heat and toxic material, diminishing inflammation and invigorating stomach, sterilizing and disinfesting; by being mixed into daily feed for feeding, the Chinese medicinal feed additive can increase body immunity and disease resistance of chickens; and the feed additive is excellent in preventing and treating such common diseases of chickens as bird flu, new-area plague, salpingitis, white diarrhea, cholera,ascariasis, laryngotracheitis, coccidiosis and colon bacillus. Application proves that the Chinese medicinal feed additive has good preventing and treating effects, easily obtained materials, low cost and no toxic side effect.

An alkyl ether derivative represented by the following general formula [1]or its salt: wherein R1 and R2 represent each a substituent such as hydrogen, halogeno or alkyl; R3 represents alkylamino, amino or hydroxyl; the ring A represents a 5- or 6-membered aromatic heterocycle or a benzene ring; m and n are each an integer of from 1 to 6; and p is an integer of from 1 to 3; shows an effect of protecting retinal nerve cells and, therefore, is useful as a preventive and / or a remedy for retinal nerve diseases such as glaucoma, diabetic retinopathy, retinal artery obstruction, retinal venous obstruction, macular degeneration and retinopathy of prematurity.

A device and a method for preventive treatment of evolving pulmonary edema in patients which are at risk of complication associated with pulmonary edema which is based on the monitoring of internal thoracic impedance of the patient. The device extracts the internal thoracic impedance from measured trans-thoracic impedance and is relatively immune to variations in skin / electrode interface impedance. The method includes identification of a stage of interstitial edema development before the appearance of a clinical indication and the beginning of an appropriate medicinal treatment in accordance to variations of the monitored internal thoracic impedance. The method also indicates the appropriate moment for terminating the medicinal treatment and can be applied when the patient and his treating physician are positioned at remote locations.

The present invention relates to the use of a C1 inhibitor (C1INH) with shorter half-life than plasma-derived C1INH for the preparation of a medicament for the transient treatment of an individual. It relates to both therapeutic and prophylactic treatment. The method of the invention allows for the administration of C1INH at certain therapeutic levels for a concise pre-determined time span. Pharmaceutical compositions based on C1INH with shorter half-lives may be used both in situations where transient treatment is merely and advantage. The advantage of the use according to the invention is that an individual is not exposed to C1INH for longer than required, since the levels of the C1INH more rapidly subsides after administration has stopped. In contrast, levels of plasma-derived C1INH would remain elevated for a prolonged period of time.

The invention provides a device and method for monitoring inflammation of the epithelium. The device consists of a head region, a handle region and an optical bundle. At least two of the optical fibers in the bundle are utilized as a source of radiation, these two fibers are at two different angles from normal. At least one of the other optical fibers is utilized as a detector for the reflected radiation, or alternatively an image guide can be used as the detector. The device of the invention can be part of an external or internal system that can include a light source, the device, a multiplexer, a spectrometer, and a computer for data analysis. The method of the invention allows for the detection and monitoring of general inflammation of the oral epithelium. The inflammation of the epithelium can be detected or monitored to diagnose diseases of the oral epithelium, monitor such diseases, monitor treatment of such diseases, or pre-screen for and monitor preventative treatments of such diseases.

The invention provides an active lactoprotein extracted from yak milk and its extraction method and use, wherein the active constituents by weight include beta-lactoglobulin 51-54, alpha-lactoglobulin 20-23, albumin bovine 9.0-11, lactoferrin 1.0-2.0, immunoglobulin 11-14, other trace nourishing elements 1.0-2.0, the preparation comprises the steps of choosing raw material, removing impurities and degreasing through centrifugation, low-temperature sterilizing, condensating the milk, degerming and thickening, thin film evaporating, freeze drying and asepsis vacuum packaging. The extracted active milk protein has substantial function for enhancing cell vitality and body defensiveness.